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Biomedical subjects

D Mukherjee

Publications and source records attributed to D Mukherjee.

191 records · Page 11Linked to original sources
PubMedDate not supplied

Long-term exposures to higher environmental temperature and body temperature: effect of chlorpromazine in relation to hypothalamic GABA.

Treatment with a single dose of chlorpromazine (CPZ; 1 mg/kg, ip) at room temperature (28 degrees +/-0.5 degrees C) significantly reduced body temperature by its anticholinergic action. Long-term exposures to higher environmental temperature (40 degrees +/-0.5 degrees C, 2 h/day, for 30 consecutive days) increased body temperature significantly by reduction of hypothalamic GABAergic activity, but this increase in body temperature was attenuated from that observed with a single exposure to higher environmental temperature (40 degrees C for 2 h). Treatment with a single dose of CPZ on the last day of 30 consecutive days of exposures to higher environmental temperature increased body temperature of rats more than that observed with long-term exposures to higher environmental temperature possibly due to (i) reduction of hypothalamic GABAergic activity, (ii) heat dissipation and (iii) reverse-anticholinergic action of CPZ at higher environmental temperature.

Animals↗
PubMedDate not supplied

Carotid and cerebrovascular disease.

Stroke remains a major public health problem, and carotid artery atherosclerotic disease causes a significant proportion of all strokes. Because the U.S. population is aging, the incidence of cerebrovascular disease is increasing, and cardiologists often are involved in the care of these patients because many of them have either occult or symptomatic coronary artery disease. We review the current status of carotid and cerebrovascular diseases and therapeutic options.

Age Distribution↗
PubMedDate not supplied

Blood pressure changes during adolescence and subsequent adult blood pressure level.

Serial data were analyzed for blood pressure recorded between the ages of 9 to 18 years for 278 children and for a subset of this group whose blood pressure was measured at the age of 30 +/- 5.0 years (n = 93). Blood pressures were measured by auscultation over the antecubital fossa with the participant seated. Systolic blood pressure was recorded when the first sound was heard, and diastolic blood pressure was recorded when all sounds disappeared (fifth phase). A linear regression model was fitted to the data for each individual, and adjustments were made for regression toward the mean using maximum likelihood procedures. There were no significant correlations between the estimated initial values of blood pressure and the rate of change from 9 to 18 years of age. The associations between the levels of blood pressure at 9 years of age and at 30 years of age were significant for systolic blood pressure only in male subjects and were not significant for diastolic blood pressure in either sex. The correlations between the rate of blood pressure change from 9 to 18 years of age and blood pressure levels at 30 years of age were nonsignificant. When the initial values and the rate of change in blood pressure from 9 to 18 years of age were taken into account simultaneously, they accounted for approximately 20% of the variation in systolic blood pressure levels at 30 years of age. This finding indicates that children with higher blood pressure levels at about 9 years of age and with rapid increases in blood pressure during pubescence may have an increased risk of becoming hypertensive.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMedDate not supplied

Surgical management of chronic mesenteric venous thrombosis--a case report.

Although mesenteric venous thrombosis is an uncommon disease, it is a diagnostic dilemma and if left untreated results in significant morbidity and mortality. The clinical presentation of mesenteric venous thrombosis (MVT) is varied and depends on the etiology. Prompt recognition and treatment is important as this may limit the progression of thrombosis. Even though medical management is the current mainstay of therapy, there have been reported cases of clinical improvement with operative management. The authors describe an improved outcome following mesenteric-systemic shunting in a symptomatic patient with acute-on-chronic MVT affecting the proximal superior mesenteric vein.

Anastomosis, Surgical↗
PubMedDate not supplied

Hepatopulmonary syndrome: prevalence and clinical profile.

BACKGROUND: The hepatopulmonary syndrome (HPS) is defined as a triad of liver dysfunction, intrapulmonary vascular dilatations (IPVD) and arterial hypoxemia. There is paucity of Indian studies regarding the prevalence of IPVD and arterial hypoxemia particularly amongst patients with non-cirrhotic portal fibrosis (NCPF) and extrahepatic portal vein obstruction (EHPVO), where liver dysfunction is not a feature. METHODS: All patients with portal hypertension and esophageal varices seen at a tertiary care hospital during 1995-98 were studied. Ultrasonography of abdomen, contrast-enhanced echocardiography (CEE), arterial blood gas analysis and assessment of alveolar-arterial oxygen gradient were done. RESULTS: Of 138 patients with portal hypertension seen during the study period, 88 fulfilled the inclusion and exclusion criteria. These included 63 with cirrhosis, 15 with NCPF and 10 with EHPVO. CEE showed IPVD in 17 (27%) patients with cirrhosis, of which 11 (17.5%) fulfilled the criteria for HPS. IPVD were also noted in 4 (26.6%) cases of NCPF and 3 (30%) of EHPVO, though only 2 (13.3%) and 1 (10%) respectively had elevated alveolar-arterial gradient and liver dysfunction in addition. Age and sex distribution and duration of symptoms were not different in patients with HPS. Patients with HPS had higher incidence of dyspnea, platypnea, clubbing and spider nevi. CONCLUSIONS: Hepatopulmonary syndrome is present in 17.5% of cirrhotics, 13.3% of patients with NCPF and 10% with EHPVO. Patients with HPS had significantly higher incidence of dyspnea, platypnea, clubbing and spider nevi.

Adolescent↗
PubMedDate not supplied

Effectiveness of training on infant feeding practices among community influencers in a rural area of west Bengal.

Total 34 Influencers were trained in a subcentre area of South 24-parganas district of West Bengal. Knowledge was imparted to community influencers on infant feeding practices through lecture, group discussion, question-answer session and hand-on-training by trained health workers. Pre-assessment was done before initiation of training. Repeat training was conducted at frequent intervals within a period of 3 months. Mean score of knowledge of influencers during pre-training assessment was 13.3 and improved thereafter-following training to 20.8 (1st assessment), 20.6 (2nd assessment), 23.7 (3rd assessment) and 25.2 (final-assessment). Repeat training had also desired impact.

Child Nutrition Sciences↗