Search PubMed⌕ Search

Biomedical subjects

D Muñoz

Publications and source records attributed to D Muñoz.

At least 55 records · Page 3Linked to original sources
PubMed1987

Contact dermatitis from Primula obconica Hance.

15 cases of contact dermatitis to Primula obconica Hance are reported, 14 female and 1 male. None were of occupational origin. The incidence among our patients increased from 0.45 to 3.4% when we included an ether extract of primula in our standard series. A doubtful patch test reaction was found in 19.6% of the patients tested. Active sensitization was observed in 5 of 20 patients retested 1-16 months later.

Dermatitis, Contact↗
PubMed1985

Aminobutyric acid greatly increases the in vivo extracellular taurine in the rat hippocampus.

The effects of gamma-aminobutyric acid (GABA) on the extracellular levels of taurine and on excitability in the dentate gyrus were studied in anesthetized rats by the dialytrode technique. The dentate gyrus was perfused by means of a dialytrode with Krebs-Ringer-bicarbonate or GABA solutions. Amino acid contents in perfusates and dentate field potentials evoked by electrical stimulation of the perforant pathway were evaluated. GABA drastically elevated the levels of extracellular taurine in a dose-dependent manner, decreasing the amplitude of the population spike. This result indicates that GABA stimulates taurine release, probably by a counter-transport process. It is suggested that in physiological conditions an increase in extracellular taurine may be produced by synaptically released GABA.

Animals↗
PubMed1984

Interactions between hippocampal penicillin spikes and theta rhythm.

The relationships between theta rhythm and epileptic spikes, evoked by penicillin, were studied in the rat hippocampus. Records were taped and processed off-line, and autocorrelation functions, averages and power spectra of the EEG and frequency histograms of the epileptic spikes were calculated. Results showed that: (1) epileptic spikes tend to occur in a preferred phase of theta rhythm; (2) they provoked a reset of the phase of theta rhythm, acting as internal stimuli; (3) epileptic spikes decreased in frequency and were often abolished when theta rhythm was evoked; (4) these effects appeared to be dependent on the medial septal pathway. These findings indicate the existence of an antagonism between two hippocampal phenomena (epilepsy and theta rhythm). On the other hand, they also seem to be interrelated since the generation of one is accompanied by a reciprocal decrease in the other.

Animals↗
PubMed1984

Meningitis caused by Mycobacterium fortuitum.

A previously healthy 16-yr-old Caucasian male developed a relapsing purulent meningitis shortly after a motor accident in Venezuela, in which he received a small wound with a retained foreign body in the sacral region. Repeated initial physical examinations, radiographs of lumbar and sacral regions, and contrast myelography failed to demonstrate a cerebrospinal fluid leak or bone involvement, and Mycobacterium fortuitum was repeatedly isolated from the cerebrospinal fluid. Finally, from the originally "cured" lumbar wound a purulent material was obtained from which M. fortuitum was also isolated. A retained foreign body was removed, and an abscess and fistulous tract were incised and drained. The patient responded dramatically to the combination of isoniazid plus co-trimoxazole and surgery.

Adolescent↗
PubMed1977

Activity of fosfomycin in the treatment of bacterial infections.

30 patients with different infections were treated with fosfomycin: 13 had urinary infections, 14 had pneumonial infections, 2 had staphylococcus osteomyelitis and 1 had staphylococcus septicemia. The antibiotic was administered in doses ranging from 100 to 230 mg/kg/day, with periods of treatment that lasted from 5 to 58 days. The doses were administered every 6 h by the oral or intramuscular route. A total of 35 organisms were isolated: 7 E. coli, 7beta-hemolitic Streptococcus, 6 Proteus sp., 6 S. aureus, 6 S. viridans, 2 Klebsiella sp. and 1 negative coagulase S. aureus. All were sensitive to fosfomycin in vitro, as was revealed by the diffusion in discs method. The therapeutic results were good in 29 of the 30 cases (96.7%). There were no important side effects. A patient complained of a local pain in the area of the injection. The transaminases increased temporarily in 2 patients. One patient had a moderate eosinophilia while under treatment.

Administration, Oral↗