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Biomedical subjects

D Morris

Publications and source records attributed to D Morris.

At least 235 records · Page 13Linked to original sources

Evaluation of the electrosleep machine.

Seven dogs were intensively studied to determine the clinical, physiological, biochemical, and pathological effects of the electrosleep machine. Both the normal dose and a high dose of current was studied. The most notable finding was an increasing number of histologic findings with increasing current dose. There is some question regarding the true nature of these findings. Other changes which were less definite included: EEG slowing and depression of the amplitude of the B-wave in the ERG. Suggestive changes included a chronic increase in pulse rate. Because of the small number of subjects, further studies are indicated to investigate further the findings of this study.

17-Ketosteroids↗

Adolescence.

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Adolescent↗

Ocular flutter.

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Central Nervous System Diseases↗

The kinetic properties of human placental choline acetyltransferase.

1. Michaelis constants for human placental choline acetyltransferase were shown to be dependent on the concentration of the second substrate present. The primary plots indicate a sequential rather than a Ping Pong mechanism and are of the same type with 300mm- and 500mm-sodium chloride. 2. Similar results have been obtained with rabbit brain choline acetyltransferase. 3. Product inhibition of the forward reaction has been studied. CoA inhibits competitively with respect to acetyl-CoA and non-competitively with respect to choline. Acetylcholine inhibits competitively with respect to choline and non-competitively with respect to acetyl-CoA. No inhibition is given by acetylcholine when the enzyme is saturated with choline. 4. It is concluded that human placental choline acetyltransferase has an ordered mechanism of the Theorell-Chance type.

Acetylcholine↗