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D Morley

Publications and source records attributed to D Morley.

120 records · Page 7Linked to original sources
PubMedDate not supplied

Drug-like annotation and duplicate analysis of a 23-supplier chemical database totalling 2.7 million compounds.

We have implemented five drug-like filters, based on 1D and 2D molecular descriptors, and applied them to characterize the drug-like properties of commercially available chemical compounds. In addition to previously published filters (Lipinski and Veber), we implemented a filter for medicinal chemistry tractability based on lists of chemical features drawn up by a panel of medicinal chemists. A filter based on the modeling of aqueous solubility (>1 microM) was derived in-house, as well as another based on the modeling of Caco-2 passive membrane permeability (>10 nm/s). A library of 2.7 million compounds was collated from the 23 compound suppliers and analyzed with these filters, highlighting a tendency toward highly lipophilic compounds. The library contains 1.6 M unique structures, of which 37% (607,223) passed all five drug-like filters. None of the 23 suppliers provides all the members of the drug-like subset, emphasizing the benefit of considering compounds from various compound suppliers as a source of diversity for drug discovery.

Journal Article↗
PubMedDate not supplied

Severe measles: some unanswered questions.

The severity of measles is greatest in the developing countries, where a high proportion of children have nutritional deficiencies. Nutritional deficiencies may play a part in the complications that result from measles infection. Nutritional deficiencies may also be the reason for the young age at which infection is found in children in developing countries; the child with severe measles and an immune system that is suppressed as a result of malnutrition secrets the virus three times longer than does a child with normal nutrition.

Child, Preschool↗
PubMedDate not supplied

Complications common to ventricular assist device support are rare with 90 days of DeBakey VAD support in calves.

The DeBakey VAD is a miniaturized, electromagnetically driven axial flow pump intended for long-term ventricular assist. Safety and performance data from six calves implanted with the complete DeBakey VAD system are reported elsewhere; here we describe complications and necropsy findings for these same six animals, all of which survived 90 days. The study was conducted according to a uniform protocol, which included anticoagulation and antibiotic prophylaxis. Clinical complications tracked included bleeding, cardiovascular abnormalities (e.g., arrhythmias, tachycardia unrelated to pain, bradycardia), hemolysis, hepatic dysfunction, renal dysfunction, thromboembolism (neurologic or peripheral), or infection. Each adverse event was retrospectively categorized with regard to severity (mild, moderate, severe) and relationship to device. Clinical findings were confirmed by necropsy. There was no evidence of systemic infection, thromboembolism, hemolysis, or renal or hepatic dysfunction in these six animals during the study period. A single adverse event was noted in each of two of the calves. Both events were considered mild according to the predefined criteria. Bleeding related to the surgical implantation procedure and requiring reoperation occurred in one animal. The other animal had evidence of a superficial infection at the exit site of the cables on the left lateral thoracic wall; the infection did not extend into the thoracic cavity. Chronic, healed small renal infarct scars were present in several animals. Mild valvular endocardiosis was observed in two calves and mild fibroelastosis was present in the endocardium at the site of the inflow cannula in three calves; however, these lesions were not considered clinically significant. No other gross or histologic abnormalities were noted at necropsy. In conclusion, calves implanted with the complete DeBakey VAD for 90 days demonstrated few complications and had no significant necropsy findings. Complications common to ventricular assist device (VAD) support (i.e., hemolysis, infection, bleeding, thromboembolism) were rare during long-term support (90 days) with the DeBakey VAD.

Animals↗
PubMedDate not supplied

Distance learning for primary health care.

The United Nations' stated objective is to bring primary health care to all by the year 2000. To reach this goal, the health profession will have to be involved in a greater change than has ever taken place since the introduction of scientific medicine. Important advances in educational methods offering many advantages for developing countries have taken place. The most valuable may be "distance learning". A small group led by an educationist would be involved in preparing distance learning material appropriate for health teams offering primary care in villages and slums. As a result of this training, the teams would be better prepared to tackle the major health problems of the communities they serve. In children, these problems are malnutrition, diarrhea and respiratory disease, which together account for half the number of childhood deaths.

Allied Health Personnel↗
PubMedDate not supplied

Midwives and HIV: the case for continuing education.

On a worldwide scale, HIV transmission figures continue to rise dramatically. This paper looks at the impact the pandemic is likely to have on women of childbearing age in the future. The author finds that if current statistical predictions are to become a reality, midwives and perinatal nursing staff are increasingly likely to be exposed to clients with the disease or carrying the virus. Continuing staff education, she says, is crucial.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

Serum myoglobin does not predict cardiac allograft rejection.

Noninvasive studies are useful, but limited, in detecting rejection among cardiac allograft recipients. Because an elevated serum myoglobin level is a sensitive indicator of necrosis in acute myocardial infarction, we postulated that myoglobin levels might correlate with the presence, absence, or degree of rejection. Therefore we prospectively measured serum myoglobin levels at the time of endomyocardial biopsy in 45 heart transplant recipients and correlated these levels with biopsy scores (grade 0 through grade 4). There was no significant difference in mean myoglobin levels among patients with grade 0 biopsy scores and those with grade 1 through grade 4 scores. Serial myoglobin levels and endomyocardial biopsy specimens were obtained in five patients during a 4- to 9-week period; no significant directional change in myoglobin levels appeared to correlate with changes in endomyocardial biopsy score. In addition, a normal myoglobin level did not exclude, nor did an elevated level confirm, any grade of rejection. We conclude that neither the absolute level nor a directional change in serum myoglobin is useful in identifying rejection among heart transplant recipients.

Biomarkers↗
PubMedDate not supplied

Posttransplantation hemodynamics and exercise function are not affected by body-size matching of donor and recipient.

Because the number of heart transplantations performed is limited by the number of available donor hearts, many centers have expanded the acceptable criteria for donor hearts in an attempt to provide a sufficient number of donors for the number of patients awaiting heart transplantation. Traditionally, body-size matching has been an important criteria for matching donors with potential heart transplant recipients. Although initially thought to be detrimental, studies have shown no difference in survival of patients who receive hearts from smaller donors, but heart performance in this subset of patients who receive undersized hearts has not been extensively examined. We assessed exercise capacity and 1-year posttransplantation hemodynamics in 72 consecutive adult orthotopic heart transplant recipients, grouped according to donor-recipient weight ratio and the ratio of donor to recipient body surface area. Total exercise time and relative oxygen consumption were not significantly different among three groups of patients grouped according to donor-recipient body weight ratio as follows: low, 0.60 to 0.79; mid, 0.80 to 1.0; high, more than 1.0. No difference was noted among the three donor-recipient weight ratio groups with respect to 1-year posttransplantation hemodynamics. Similarly, 1-year posttransplantation hemodynamics were not different between patients with a body surface area ratio of less than 1.0 versus those with a body surface area ratio of 1.0 or more. Differences in pretransplantation hemodynamics or graft preservation did not affect our results. Neither donor-recipient weight ratio nor body surface area ratio correlated with any posttransplantation hemodynamic measurement.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗