Biomedical subjects
D Moore
Publications and source records attributed to D Moore.
The bandwagon syndrome.
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The effect of histamine releasers on the output of prostaglandins from rat diaphragms.
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The mutagenic action of N-methyl-N'-nitro-N-nitrosoguanidine on Coprinus lagopus.
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Sources of carbon and energy used by Coprimus lagopus sensu Buller.
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Solid tumor chemotherapy with mitomycin C.
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Idiopathic hypertrophic cardiomyopathy involving the right ventricle.
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Christmas disease, color-blindness and blood group Xga.
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Four new linkage groups in Coprinus lagopus.
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Purine-requiring auxotrophs of Coprinus lagopus (sensu Buller).
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Detection of small ventricular septal defects. Comparison of selective left ventricular cineangiography with indicator-dilution techniques.
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Stokes-Adams attacks in a small child treated by prolonged use of an indwelling pacing catheter.
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Atrioventricular block as a complication of cardiac catheterization in infants and children.
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Role of changes in accommodation and convergence in the perception of size.
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Types of damage caused by various cracking and crushing methods used for measuring egg shell strength.
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Herniation of the cecum through the foramen of Winslow.
A case of cecal herniation through the foramen of Winslow is presented. Although rare in occurrence, it carries a high mortality risk when diagnosis and treatment are delayed. A better understanding of the nature of this hernia and appreciation of the classic radiographic findings will allow for earlier recognition and treatment.
Nutritional value of ganoderma extract and assessment of its genotoxicity and antigenotoxicity using comet assays of mouse lymphocytes.
The nutritive composition of a hot aqueous extract of wild Ganoderma fruit bodies was determined. This extract was assessed for cytotoxicity and in vivo genotoxicity by both acute and subchronic exposure of mice (given by mouth at a dose equivalent to extract of 220g fresh Ganoderma fruit body/kg body weight). To test any alleged protection against mutagens by Ganoderma treatments, the mice were injected intraperitoneally with the radiomimetic mutagen ethyl methanesulfonate (EMS), and after 24hr of treatment their lymphocytes were examined using the comet assay. Ganoderma extract consisted of Folin-positive material (68.9% of dry weight), but protein comprised only 7.3% of dry weight. Glucose accounted for 11. 1% and metals 10.2% of dry weight (K, Mg and Ca being the major components with Ge (often touted as being of value in sales literature for Ganoderma preparations) having the fifth highest metal concentration at 489 microg/g). In comparison to rodent chow, Ganoderma extract was a modest dietary supplement. No evidence was found for genotoxic chromosomal breakage nor cytotoxic effects by Ganoderma extract in the mouse, nor did it protect against the effects of ethyl methanesulfonate. We found no support in this study for the extract having any value in protecting against the test mutagen.