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Biomedical subjects

D Miranda

Publications and source records attributed to D Miranda.

69 records · Page 4Linked to original sources
PubMedDate not supplied

Treatment of bancroftian filariasis in Recife, Brazil: a two-year comparative study of the efficacy of single treatments with ivermectin or diethylcarbamazine.

The effectiveness of single oral doses of ivermectin (200 or 400 micrograms/kg) and diethylcarbamazine (DEC, 6 mg/kg), preceded 4 d earlier by either placebo or very small doses of these drugs, was compared, over a 2-year period, in a double-blind trial in 67 microfilaraemic Brazilian men with bancroftian filariasis. Regimens containing ivermectin alone decreased the number of microfilariae significantly faster and more effectively for the first month after treatment than regimens containing DEC alone, but the latter were significantly more effective throughout the second year after treatment (1.7-8.2% of pretreatment levels with DEC vs. 12.6-30.8% with ivermectin during that period); the higher ivermectin dose showed a tendency towards more effectiveness than the lower dose. Most effective was the combination of ivermectin (20 micrograms/kg) followed 4 d later by DEC (6 mg/kg), with reduction of microfilaraemia to 2.4% of pretreatment levels at 2 years. Adverse reactions were well tolerated with all regimens, the reactions being significantly more generalized (i.e., fever) following ivermectin and localized (i.e., scrotal inflammatory nodules around dying adult worms) following DEC. Further trials of single-dose combination therapy vs. single high doses of ivermectin or DEC should determine the ideal regimen for treatment and control of bancroftian filariasis.

Administration, Oral↗
PubMedDate not supplied

Highlights of the 1st International Congress of Wavefront Sensing and Aberration-free Refractive Correction.

As we review the many new and evolving techniques for treating patients with customized ablation, it is obvious that there is a rapid evolution of technology and thought. Newly refined diagnostic technology, such as wavefront sensing, and more sophisticated spot laser delivery systems with eye tracking gives the refractive surgical team greater flexibility in tackling challenging optical abnormalities. These highlights of the 2000 Congress now set the stage for further development, outlined in the following selected papers from the 2001 Congress.

Cornea↗
PubMedDate not supplied

Lessons learned during 15 years of clinical information system experience.

This article describes lessons learned during an initial intensive care unit point-of-care clinical information system implementation and subsequent expansions to other units and hospitals in a multihospital healthcare delivery system. Although the implementation and expansions were primarily successful, lessons learned include developing a broad base of support, making decisions through consensus, addressing conflict when it occurs, keeping user expectations realistic, preparing for the change process, implementing the computer information system in stages, challenging existing work processes, viewing the implementation as a process, and choosing a project leader with outstanding communication and group process skills in addition to technical skills.

California↗
PubMedDate not supplied

[Incidence of primary benign and malignant neoplasms and bone pseudotumoral lesions. An epidemiologic analysis of 585 cases diagnosed at the Faculdade de Medicina of the Universidade Federal de Minas Gerais].

The authors present an epidemiological study of 585 primary bone neoplasms and tumor-like lesions in order to investigate their incidence and distribution according to age, sex and skeletal location. A statistical agreement between the pertinent literature and the collected data was found. In this series, the most common benign neoplasms were the osteochondroma (45.3%) followed by chondroma (19.6%). Among the intermediate and malignant neoplasms, osteosarcoma was the most frequent (30.0%) followed by myeloma (16.0%). Fibrous dysplasia accounted for 46.6% of all tumor-like lesions, followed by solitary bone cyst (18.6%).

Adolescent↗
PubMedDate not supplied

[Berger's disease].

Explore the source record for details and available documents.

Adolescent↗
PubMedDate not supplied

[Precancerous lesions associated with atrophic chronic gastritis and gastric peptic ulcer].

Among the gastric lesions related to an increased risk for gastric cancer (precancerous conditions) two have deserved special attention, i.e., atrophic gastritis and peptic ulcer. In this paper the authors study the incidence of glandular dysplasia in atrophic gastritis and gastric peptic ulcer. In 148 cases of atrophic gastritis dysplastic lesions were diagnosed in 92 (62,0%): 63 cases (68,4%) with mild dysplasia, 25 cases (27,0%) with moderate dysplasia and 4 cases (4,3%) with severe dysplasia. In 329 gastric peptic ulcers examined there were 51 (15,5%) with dysplastic lesions: in 34 cases (66,6%) there was mild dysplasia, 12 cases (23,5%) moderate dysplasia and (9,8%) severe dysplasia. A prospective study with histological multiple sections from the stomach would be helpful for better understanding of these precancerous lesions.

Adult↗