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Biomedical subjects

D Miranda

Publications and source records attributed to D Miranda.

At least 37 records · Page 2Linked to original sources
PubMed1987

Changes in the polypeptide composition related to the growth response in chronically isoproterenol-stimulated mouse parotid glands.

The administration of isoproterenol induces DNA-synthesis mitosis and growth (increase in size) responses in mouse parotid glands. Both responses were uncoupled by means of daily stimulations with isoproterenol in such a way that the DNA-synthesis mitosis response was observed during the first 4 days only, whereas the growth response was continuous since the first stimulation until about day 12. In parallel to the chronic stimulation by isoproterenol, drastic changes in the polypeptide composition of parotid glands were observed. These modifications, consisting basically of the reduction in content of a couple of major poly peptides (polypeptides A and B) together with the reciprocal massive accumulation of five new polypeptides (polypeptides C, D, E, F and G), were also progressive and continuous along the chronic stimulation by isoproterenol, even after the disappearance of the DNA-synthesis mitosis response. Thus, a relationship between specific changes in the mouse parotid content of polypeptides A, B, C, D, E, F and G and the isoproterenol-induced growth response, rather than with the DNA-synthesis mitosis response, is suggested. The correlation is firmly supported by the progressive recovery of the normal polypeptide composition upon suspending isoproterenol treatment, which allows parotid glands to return to normal size parameters.

Animals↗
PubMed1986

Correlation between the induction of leukemic cell differentiation by various retinoids and modulation of protein kinases.

During retinoic acid induced differentiation of the human promyelocyte leukemia cell line HL60 and the human myeloblast cell line RDFD along the myeloid pathway, there is marked modulation of both the cyclic adenosine 3':5'-monophosphate dependent protein kinase and the phospholipid-sensitive calcium dependent protein kinase. In order to further assess whether these kinases are intimately associated with the differentiation process, we have correlated the modulation of these enzymes and phosphorylations of their substrates with the extent of differentiation induced by various retinoid derivatives. We observed that there was a direct relationship between the degree of differentiation of the two leukemic cell lines and the elevation of the cyclic adenosine 3':5'-monophosphate dependent protein kinase and phospholipid sensitive calcium dependent protein kinase activities. In addition, the increased phosphorylation of the various substrates of these enzymes also correlates with the degree of differentiation. These observations support the hypothesis that modulation of these protein kinases and phosphorylation of their substrates are necessary steps in the differentiation process.

Cell Differentiation↗
PubMed1985

Renal cortical necrosis following Bothrops jararaca and B. jararacussu snake bite.

Out of 22 patients admitted to the Intensive Care Unit of the Hospital das Clínicas, Federal University of Minas Gerais, with acute renal failure following Bothrops snake bite, 7 had renal cortical necrosis. This complication was suspected when the oligoanuric phase ranged from 21 to 28 days or when the patient, in spite of having a polyuric phase, maintained elevated blood levels of urea and creatinine after the interruption of the dialysis program, and was confirmed by a kidney biopsy. Three patients died and in two of them renal cortical necrosis was found at necropsy. Four patients were discharged from the hospital and follow-up was possible in two of them who showed recovery of renal function. Vasospasm, direct nephrotoxicity of Bothrops venom and/or disseminated intravascular coagulation leading to vascular occlusion and renal ischemia are the proposed pathogenetic mechanisms to explain renal cortical necrosis following Bothrops snake bite.

Acute Kidney Injury↗
PubMed1983

Phaeohyphomycotic cyst: a clinicopathologic study of the first four cases described from Brazil.

Four cases of phaeohyphomycosis in the form of chronic and isolated cysts are presented. The cysts were strictly confined to the subcutaneous tissue, with no involvement of the corresponding skin. Patients were asymptomatic, without satellite lesions or regional lymphadenopathy. The clinicopathologic importance of this type of phaeohyphomycosis is discussed. As far as we know, our cases are the first described from Brazil.

Aged↗
PubMed1982

A new hygroscopic condenser humidifier.

A new hygroscopic condenser humidifier for the mechanically ventilated patient has been tested. It functions as a heat and moisture exchange device (HME) with an additional hygroscopic sponge to minimize the water loss from the breathing circuit. A comparative in vitro study was undertaken with a conventional HME. The influence of tidal volume, inspiratory flow rate and minute volume on the relative humidity of the inspiratory gas and on the water loss was investigated. The new device provides adequate humidification within a broad scale of ventilatory settings. In a subsequent clinical test the hygroscopic condenser humidifier proved to be a simple and reliable way of humidification.

Humans↗
PubMed1981

Mucoepidermoid tumor of the lacrimal sac.

A 58-year-old man had a mucoepidermoid tumor of the lacrimal apparatus. Histologically the tumor exhibited clumps and nests of neoplastic cells that showed an admixture of squamous and mucussecreting cells. Histochemical stains for glycoproteins were useful in arriving at the correct diagnosis. Biologically the tumor seemed to be locally aggressive but not metastatic and should be differentiated histologically from the conventional squamous cell carcinomas, adenoid cystic carcinomas, adenocarcinomas, and adenoacanthomas. Large advanced lesions may be managed only by radical surgery, and the margins should be carefully studied for residual tumor. Frequent follow-up is recommended to detect early recurrence.

Carcinoma↗
PubMed1981

Leopard syndrome, a neural crest disorder: a case report.

A case of Leopard syndrome with full clinical expression is reported. In addition to the cardinal signs of the syndrome this patient presented some abnormalities which have not been previously described such as macroglossia, multiple dental anomalies, basilar impression and platybasia, megacolon, hypertrophy of clitoris and anal ectopy. The presence of dental anomalies and megacolon may represent involvement of the dental papillae and myenteric plexus favoring the view that the syndrome results from a derangement of the neural crest elements.

Abnormalities, Multiple↗
PubMed1981

[Giant granulo-cellular Abrikosov's tumor].

A case of Abrikossoff's granular-cell tumor is reported because of its unusually large dimensions (12.5 X 10.5 X 8.0 cm.), weight (700 g.) and supra-umbilical localization. Ample surgical excision of the tumor and reconstruction of the abdominal wall with silastic and skin graft were performed. Comments are made about the clinical, histopathological and histogenetic aspects of the neoplasia.

Abdomen↗
PubMed1980

Spontaneous aortic rupture in a malignant schwannoma.

We have described a case of malignant schwannoma (MS) originating from the posterior mediastinum with subsequent pathologic rupture of the thoracic aorta. The patient presented with acute retrosternal pain radiating to the back, and she died on the day of admission. Necropsy revealed a large hemothorax and a tumor mass involving the thoracic aorta. The histologic features of the lesion fulfilled the criteria for delineated MS. We found no similar cases of thoracic MS with consequent aorta rupture.

Adult↗
PubMed1980

Gastric polyp of the umbilicus in an 8-year-old boy.

A case of unbilical polyp composed of gastric mucosa is reported in a 8-year-old boy. This is an extremely rare lesion probably originating in remnants of the omphalo-enteric duct and mainly diagnosed in the newborn period. Clinically, this polyp should be differentiated from exhuberant proliferation of granulation tissue which represents the granuloma pyogenicum of the umbilical scar.

Abdominal Neoplasms↗