Search PubMed⌕ Search

Biomedical subjects

D Minucci

Publications and source records attributed to D Minucci.

At least 37 records · Page 2Linked to original sources
PubMed1987

Diagnostic problems of cervico-vaginal infections by HPV.

The diagnostic problems of cervico-vaginal infections by HPV have been considered. The colposcopic and cytological diagnoses have been compared with the histological one in order to evaluate the diagnostic reliability of the two methods of screening, and to seek evidence of those colposcopic and cytological aspects which, even if not pathognomic, are suggestive of HPV infection. The association between viral changes and CIN and the correlated problems have also been examined. The importance is underlined of screening and following up of HPV infections by the integrated use of colpocytology and colposcopy and of eventual aimed histologic checking as an improved prognostic evaluation, considering the potentiality of the evolutive risks of such infections.

Adolescent↗
PubMed1987

Cytological and histological features in a case of endometrial adenocarcinoma.

We have examined a case of endometrial adenocarcinoma in which the cytological sample was indicative for a histotype which was not the predominant component in the histological examination of the uterus. The cytological diagnosis was: pattern concerning adenocarcinoma poorly differentiated; the histological diagnosis was: moderately differentiated endometrial adenocarcinoma. The Authors underline the usefulness of the integration of histological and cytological examinations for a better prognostic evaluation of endometrial adenocarcinoma.

Adenocarcinoma↗
PubMed1986

Cervico-vaginal infections by HPV: aspects of natural history.

We have studied the incidence, evolution and association with CIN of the cervico-vaginal infections by HPV. We noted over a period of time the diverse behaviour of "benign" and atypical alterations through colposcopic and cytohistological monitoring. We also noted the therapeutic efficacy in relation to the type of viral alterations and to the associated lesion (CIN). We emphasize the importance of accurate diagnosis, of aimed and personalized therapy and follow-up, in consideration of the natural history and of the evolutive potentiality of HPV infections.

Female↗
PubMed1985

Colpocytology in children: 3 cases of botryoid sarcoma.

We have examined some aspects of the colpocytological preparations of 3 children affected by leucorrhea accompanied by bleed up, from which was diagnosed botryoid sarcoma. The characteristic element met in the preparations was the altered epithelial maturation in prepuberal children; the presence of groups of intermediate and superficial cells, with nuclei sometimes diskaryotic, of anucleate scales and of discharging phenomena. In one case it was possible to observe even neoplastic and slightly differentiated cells. The Authors underline the usefulness of carrying out a colpocytological examination in the initial diagnostic stage with children affected by leucorrhea, above all if this is accompanied by bleeding.

Child, Preschool↗
PubMed1985

Steroids receptors in physiological and pathological features of the cervix.

The presence of ER and PgR in human cervical tissues was investigated. The material consisted of receptor measurements in tissue sample obtained from normal and abnormal colposcopical pictures (leukoplakia, mosaic, punctation, atypical transformation), in 38 outpatients. The receptor assays were performed by a dextran-coated-charcoal (DCC) technique.

Cervix Uteri↗
PubMed1984

Colposcopic pictures in cervical intraepithelial neoplasia grade III.

This study concerns 414 women affected by cervical intraepithelial neoplasia grade III. In each case we have considered and compared the colposcopic examination and the cyto-histologic type of lesion. Ectopy and/or typical transformation prevail in atypical metaplasia. Leukoplakia has its highest incidence in severe dysplasia, is prominent in severe dysplasia and carcinoma in situ unless these two lesions are combined atypical metaplasia. The mosaic prevails in atypical metaplasia, but appears in a prominent form in carcinoma in situ only, whereas the punctation prevails in carcinoma in situ. When the suspect white areas appear in association their incidence in the various CIN III lesions they do not vary. The red suspect areas are rather infrequent, while the atypical transformation is absent in atypical metaplasia, fairly frequent in carcinoma in situ and prevails significantly in microinvasive carcinoma.

Adolescent↗
PubMed1984

Cytological evaluation of endometrial hyperplasia in relation to histological pictures.

The Authors analyse possible parameters of cytological evaluation which can be used for the grading of endometrial hyperplasias and the diagnostic differentiation between atypical hyperplasia and adenocarcinoma. They consider 77 women who underwent endometrial cytology by aspiration just before diagnostic examination of the uterine cavity. Results show that in atrophic endometrium desquamation in clusters of less than 100 cells prevails whereas proliferative and secretory endometrium presents mainly clusters of 100-500 regularly stratified cells. Hyperplasia show progressive increase in isolated cells; "branched" glands appear rarely in hyperplasia with minimal atypia while prevailing in hyperplasia with severe atypia and adenocarcinoma. Simple layers prevail in atrophic endometrium, stratified regular layers prevail in proliferative and secretory endometrium; three-dimensional clusters appear in hyperplasia with minimal atypia and become significant with severe atypia. Adenocarcinoma is characterized by haematic and necrotic background, high percentage of isolated cells and prevalence of clusters of less than 100 cells, mainly three-dimensional. In addition it shows a significant incidence of papillary and rosette-like arrangements and abnormal cytoplasmic vacuolization.

Adenocarcinoma↗
PubMed1982

Lymphoplasmacyte infiltrate in cervical intraepithelial neoplasia grade III.

The behaviour of the lymphoplasmacyte reaction, regarded as an immune defence reaction of the organism, has been evaluated in 167 patients affected by cervical intraepithelial neoplasia or by microcarcinoma. It was observed that in surely in situ forms (atypical metaplasia, severe dysplasia and carcinoma in situ) there is a clear prevalence of cases with a minimal or absent reaction, while in the potentially invasive carcinoma and in the microcarcinoma there is a predominance of cases with a marked reaction, as if the first biological modifications that lead to invasion were accompanied by a massive activation of the immune defence mechanisms. We finally noticed that no relation exists between the appearance of CIN-lesion recurrences and the intensity of the stromal reaction. This further confirms the hypothesis that in the first steps of the carcinogenic process exogenous causes are mainly involved.

Adult↗
PubMed1982

Diagnosis and treatment of preinvasive and microinvasive cervicocarcinoma.

The mortality rate of cervicocarcinoma has significantly decreased over the last few years, thanks to early diagnosis. Prophylactic and therapeutical interventions, at different stages, are therefore necessary to eliminate or, at least, decrease the incidence of this pathology. Between 1975 and 1980, during a cytologic depistage carried out at the Institute of Gynecologic and Obstretic Clinic of Padua University, we examined 72 cases of patients who had undergone the following diagnostic iter: colposcopy, cytology, direct biopsy and conization. Various parameters were analyzed, notably with regard to cases of serious dysplasia, carcinoma in situ, neoplasia with beginning invasion of the glandular necks and microinvasive forms.

Adult↗
PubMed1982

Post treatment behaviour of cervical intraepithelial neoplasia - grade III.

The behaviour in time of cervical intraepithelial neoplasia grade III has been evaluated in 141 patients treated for CIN III. It was observed that surgery ensures the higher healing-rate, whether hysterectomy or conization are performed, while diathermocoagulation seems unsatisfactory. Colposcopy, colpocytology and sight biopsies of the cervical canal, portio and vagina, which provide a precise lesion-map, are then essential investigations to make the subsequent treatment a truly radical one. A very close monitoring of patients, treated for CIN III, seems required in the first year after surgery, when we observed the highest rate of persistence and recurrences, while, subsequently, their incidence decreases as time passes by.

Biopsy↗
PubMed1982

Incidence of single or associated "CIN III" lesions according to age.

The incidence of single or associated CIN III lesions has been evaluated in 520 patients. 48.92 +/- 13.89 years is the mean age of incidence. Atypical metaplasia has the lowest mean age and is the only CIN III lesion to affect patients under 20 and never to be found--individually--after the age of 50. Severe dysplasia reaches its maximum incidence in the fourth decade. Carcinoma in situ has the highest mean age, reaching its maximum incidence in the fifth decade. But when it is associated with atypical metaplasia, the age shifts to the fourth decade. Apparently, these results confirm the role of "precursor" of atypical metaplasia. Severe dysplasia and carcinoma in situ are later stages of the cervical carcinogenesis. Furthermore, the high rate of associated lesions provides further evidence of their similarity and "common origin", with important prognostic and therapeutical implications.

Adult↗