Biomedical subjects

D Minckler

Publications and source records attributed to D Minckler.

24 records · Page 2Linked to original sources

PubMed1983

Histopathologic and ultrastructural analysis of congenital corneal staphyloma.

Although the visual prognosis for eyes with congenital corneal staphyloma has been considered hopeless, we successfully treated a 1-month-old girl with this condition. We performed two penetrating keratoplasties, operating on the left eye first and then, one week later, on the right eye. During each procedure, we totally resected the staphyloma and excised the iris which was adherent to the posterior surface of the cornea. We then sutured an 11-mm corneal button into place with 34 interrupted 10-0 nylon sutures. Light and transmission electron microscopy of the Descemet's membrane and endothelium. The left eye had two rejection episodes and underwent a second penetrating keratoplasty. The graft in this eye is now opaque. The child follows objects well with her right eye.

Cornea↗

PubMed1980

Orbital abscess.

A staphylococcal orbital abscess developed in a 55-year-old diabetic woman. Initial antibiotic therapy was apparently incomplete and resulted in an unusual clinical manifestation for an orbital infection. These unusual features included an insidious course of monocular visual loss and proptosis in the absence of fever, substantial orbital pain, and evidence of sinus disease; pancytopenia rather than leukocytosis was present. Surgical drainage followed by intravenous and oral antibiotic therapy resulted in marked clinical improvement, including a partial return of visual acuity. In the patient, however, a staphylococcal osteomyelitis of the shoulder and subsequent fatal septicemia developed several months later. Orbital infection continues to be a life-threatening condition, especially in debilitated patients.

Abscess↗

PubMed1980

Orbital and adnexal lymphomas. A multiparameter approach.

The application of immunologic, cytochemical, and electron-microscopic technics to the study of lymphoid lesions of the orbit and adnexa was found to enhance the accuracy of diagnoses of malignant lymphoma in five challenging referral cases. Although careful specimen collection, ideal fixation, and processing constitute the cornerstone of the morphologic diagnosis of nodal and extranodal lymphomas, the immunologic characterization of these lymphoproliferative disorders is emphasized as an especially useful diagnostic parameter. The occurrence of false-negative diagnoses of pseudolymphoma of the orbital region may be partially explained by a failure to recognize the relatively frequent plasma-cytoid lymphocytic lymphoma, a distinctive entity that may mimic a reactive inflammatory process. All of the cases of malignant lymphoma reported represented stage I or stage II disease, suggesting that primary lymphoma of the orbital region may be a disease with a favorable prognosis.

Adult↗

PubMed1979

Photocoagulation of malignant melanoma.

A 59-year-old woman developed a pigmented, expanding posterior pole choroidal lesion nasally that was clinically consistent with malignant melanoma. She refused enucleation, but agreed to a trial of photocoagulation therapy. Four weeks after photocoagulation, a reaccumulation of pigmentation and apparent elevation prompted a second photocoagulation treatment. During the second photocoagulation episode corneal edema occurred, and thereafter the fundus view was poor. Again, four weeks after the second treatment there appeared to be increasing pigmentation and possible elevation in the lesion centrally. Because of apparent continued growth of the tumor, the globe was enucleated 82 days after the initial photocoagulation. Serial section histopathologic examination of the lesion revealed only rare neoplastic cells along the base of the lesion. However, myriad pigment-laden macrophages were present around a central area of necrosis. Pigment accumulation within macrophages had simulated tumor growth clinically.

Choroid Neoplasms↗

PubMed1979

Pyogenic granuloma of the cornea simulating squamous cell carcinoma.

A case of pyogenic granuloma involving the cornea simulated recurrent squamous cell carcinoma clinically and was misdiagnosed as invasive squamous cell carcinoma on biopsy. Ophthalmologists and pathologists should be aware of the capability of the corneal or conjunctival tissues to mount a granulation tissue response to injury.

Aged↗

PubMed1978

Adenocarcinoma of the retinal pigment epithelium.

A 57-year-old woman complaining of decreased vision for six months had a mass expanding the choroid inferonasally in the right eye. Clinical examination, ultrasonography, and fluorescein angiography were consistent with a malignant melanoma. The eye was enucleated and pathologic studies showed an adenocarcinoma of the retinal pigment epithelium (RPE). Malignant tumors of the RPE may simulate exactly choroidal melanomas clinically, but apparently have a much better prognosis, in that very few cases have been documented to produce metastatic disease. The vast majority of cases studied histopathologically, in which a diagnosis of adenocarcinoma of the RPE has been made, are low-grade malignant neoplasms with the absence of invasion beyond the choroid or lamina cribrosa at the time of enucleation.

Adenocarcinoma↗