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Biomedical subjects

D Metselaar

Publications and source records attributed to D Metselaar.

33 records · Page 2Linked to original sources

Poliomyelitis: epidemiology and prophylaxis. 1. A longitudinal epidemiological survey in Kenya.

The results of a long-term survey of poliomyelitis in Kenya are reported. Virus was isolated from patients and a limited number of sera were also tested for antibodies. The purpose of the investigation was to elucidate the epidemiological characteristics of the disease and to determine whether epidemics could be predicted. A 3-year rhythm was found in the circulation of type 1 poliovirus, making possible the prediction and hence, on two occasions, the curbing or prevention of epidemics.

Animals↗

Poliomyelitis: epidemiology and prophylaxis. 2. Distribution of oral trivalent vaccine by lay volunteers.

In contrast to other vaccines, oral poliomyelitis vaccine is ingested, in the form of drops. In countries with insufficient health personnel, countrywide vaccination campaigns should therefore be possible at little cost if use is made of lay volunteers. The feasibility of such a method was tested in a pilot project carried out in a district of Kenya. The response of volunteers and parents was good and coverage of the susceptible child population was sufficient to recommend this method for a countrywide campaign in the event of a threatening epidemic. Alternatively, such a team could travel around the country, organizing campaigns in one district after another. Because epidemics in Kenya occur at regular intervals the territory should be covered within 3 years.

Child↗

Investigations into yellow fever virus and other arboviruses in the northern regions of Kenya.

Previous studies having shown an appreciable level of yellow fever immunity to exist in northern Kenya, further epidemiological and serological surveys were carried out there in 1968 in an attempt to define more clearly the distribution of yellow fever and to locate possible vector and reservoir hosts of the disease; these surveys also provided information on a number of other arboviruses.Altogether 436 sera from 5 areas in northern Kenya were screened by haemagglutination-inhibition tests with 8 antigens, and 107 of these sera by neutralization tests for Group-B arboviruses. Small numbers of yellow-fever-immune adults were found in Ileret, Garissa, Loglogo and Mikona. At Marsabit high proportions of immune adults and children were found among the Burgi tribe. As the Burgi are permanent agricultural workers on Marsabit Mountain, an entomological investigation was made, over 15 000 mosquitos being collected. From these, 13 strains of Pongola virus, 1 strain of Semliki Forest virus and an unidentified virus were isolated, but no yellow fever strains. Aedes africanus and Aedes simpsoni were not found at Marsabit; small numbers of Aedes aegypti were collected biting man. The vector potential of other mosquitos collected (particularly Mansonia africana, which is present throughout the year) is discussed.

Adolescent↗

Yellow fever immunity surveys in northern Uganda and Kenya and eastern Somalia, 1966-67.

Recent epidemics of yellow fever in eastern Africa have stimulated serological surveys in the Karamoja district of Uganda, the northern frontier district of Kenya and the Giohar district of Somalia. All sera collected in the surveys were screened for group B arbovirus antibody using the HI test. Yellow fever immunity was confirmed by the mouse-protection test.No yellow fever immunity was found in sera collected from a residential tribal group at Karamoja but a small number of samples from persons who had previously lived outside the district showed immunity. Immunity was detected in sera from areas of the Northern Frontier district of Kenya. It is thought that this immunity may, in some areas, have resulted from extensions of the Ethiopian epidemic of 1960-62 into the region, but in another area of the district the immunity seems to have arisen from continuing focal transmission within Kenya. Yellow fever immunity was also detected in Somalia.

Adolescent↗