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Biomedical subjects

D Merrill

Publications and source records attributed to D Merrill.

30 records · Page 2Linked to original sources
PubMed1982

An alternative to ecologic regression analysis of mortality rates.

A number of recent papers have used geographically defined data and linear models to study the relationship between a series of epidemiologic factors and the frequency of disease. This "ecologic regression" approach involves serious problems of interpretation. An alternate approach is discussed that does not depend on statistical models, produces easily interpreted results and yields statistical summaries that approximately parallel regression analysis. This alternative procedure is illustrated by using acute lymphocytic leukemia mortality data on a county level from among white females less than five years of age between 1969-1977.

Child, Preschool↗
PubMed1981

Requirement for OKT8+ suppressor cell proliferation for suppression by human newborn T cells.

The percentage of cells bearing the suppressor phenotype OKT8+increases in PWM-stimulated cultures of human newborn lymphocytes. Prevention of this increase either by adding 50 microM deoxyguanosine to the cultures of by pretreating the newborn cells with OKT8 and complement reduced the suppressor activity of newborn T cells. These results suggest that newborn T cells are not intrinsically suppressive, but that they become so in vitro after stimulation by PWM.

Adenosine↗
PubMedDate not supplied

Detection of excess disease near an exposure point: a case study.

Many studies have evaluated the likelihood of adverse health effects associated with environmental contamination from point source exposures. Two statistical measures used in these studies are the ratio, R, of the observed to the expected number of cases occurring in the area containing the point and the average distance, D, between the cases and the point. This paper estimates the probability of detecting an association between disease and exposure when one actually exists (power) for R and D for several specific and plausible statistical models. Results are presented in the context of rare diseases such as congenital malformations. The practical implications of using these measures for the evaluation of risk of disease in environmental epidemiologic investigations are discussed.

California↗