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Biomedical subjects

D McLeod

Publications and source records attributed to D McLeod.

At least 217 records · Page 12Linked to original sources
PubMed1979

Ultrasonic examination in severe diabetic eye disease.

B-scan ultrasound of the posterior segment is reported in 154 patients with severe diabetic eye disease. Epiretinal fibrosis, vitreous haemorrhage, vitreous detachment, and retinal detachment were frequently diagnosed. The ultrasonic findings are discussed in relation to the pathological changes in the vitreous in proliferative diabetic retinopathy.

Adult↗
PubMed1978

Papilloedema.

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Humans↗
PubMed1978

Fundus signs in temporal arteritis.

A patient with temporal arteritis developed a variety of ischaemic lesions in the eyes. Infarction of the inner retina and optic nerve head was delineated on presentation by white swelling in the retinal nerve fibre layer. The role of interrupted axoplasmic transport in the production of this sign is discussed. Outer retinal infarction was also noted on presentation and subsequently gave rise to striking pigmented scars.

Aged↗
PubMed1978

Vitreous surgery.

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Eye Diseases↗
PubMed1978

Partial central retinal artery occlusion.

The clinical picture of multiple circumpapillary cotton-wool spots and mild ischaemic swelling of the inner retina is attributed to partial occlusion of the central retinal artery. The pathophysiological basis of the fundus signs is discussed and the role of interrupted axoplasmic transport in the development of the cotton-wool spots is emphasized.

Arterial Occlusive Diseases↗
PubMed1978

Ultrasonic examination of the traumatized eye.

Ultrasonic examination may be used to assess ocular damage if the media are opaque after blunt or penetrating injury. In eyes with retained foreign material, ultrasound may also be used to aid localization of the foreign body.

Eye Foreign Bodies↗
PubMed1978

Closed vitrectomy after trauma.

The results of vitrectomy in fifty traumatized eyes were assessed, and six types of pathological change resulting from trauma identified. The anatomical and visual results were good except where surface vitreo-retinal traction was present either at the vitreous base or posteriorly.

Adolescent↗
PubMed1977

The role of axoplasmic transport in the pathogenesis of retinal cotton-wool spots.

Small retinal arterioles in the pig retina were occluded by argon laser photocoagulation and the morphology and topography of the resulting lesions studied by ophthalmoscopy, histology, and electron microscopy. Two days after laser coagulation ischaemic necrosis of the inner retina was observed in the territory of occluded arterioles, and swollen axon terminals packed with cytoplasmic organelles were found in the retinal nerve-fibre layer on the peripheral border of the infarcts and their border nearest to the disc. These swellings gave rise to localised zones of opacification (cotton-wool spots) at the borders of the retinal infarcts, and similar zones developed in relation to the laser burns. Amino-acid uptake and transport in retinal ganglion cells was studied in these animals by autoradiography following an intravitreal injection of tritiated leucine. When 3H-leucine was injected at the same time as laser coagulation and arteriolar occlusion, label became concentrated in the swollen axon-terminals on the peripheral aspect of 2-day-old infarcts but was absent from the terminals on the disc side of infarcts. The accumulation of 3H-leucine and organelles was attributed to interruption of orthograde axoplasmic transport. When 3H-leucine was injected into the vitreous 2 days prior to laser occlusion, label became distributed throughout the axoplasm and then accumulated in swollen axon terminals on both sides of infarcts after a further 2 days. An obstruction to both orthograde and retrograde axoplasmic flow was thus demonstrated. We concluded that cotton-wood spots should be redefined as accumulations of cytoplasmic debris in the retinal nerve-fibre layer caused by obstruction of orthograde or retrograde axoplasmic transport in ganglion cell axons.

Animals↗
PubMed1977

Rapid B-scanning of the vitreous.

Ultrasonic examination is an essential investigation in most patients awaiting vitrectomy. Rapid B-scanning of the vitreous is described utilising a new system capable of high resolution and good tonal quality. Several patterns of haemorrhagic invasion of the vitreous cavity are illustrated, together with detachment, collapse, and retraction of the vitreous gel.

Eye Diseases↗