Biomedical subjects
Publications and source records attributed to D McKay.
We review the experience in treating congenital absence of the radius at Shriners Hospital in Shreveport. The prognosis for hand function in patients treated nonoperatively is poor to fair, while a minority of patients have good function after operative treatment.
A carbon monoxide (CO)-intoxicated patient developed increased permeability-type pulmonary edema demonstrated by a normal capillary wedge pressure and production of protein-rich edema fluid. To investigate the effect of CO on alveolar-epithelial permeability, a radio-active labelled isotope, 51Cr-EDTA (MW 377), was instilled into the airways of rabbits. Subsequent egress of the marker from the lungs into arterial blood was determined in serial arterial blood samples. The 51Cr-EDTA counts increased significantly within 15 minutes in the CO-exposed animals, compared with the control animals, while dynamic lung compliance fell, airways resistance rose, and arterial blood pressure decreased. Ultrastructural study of the lungs of CO-exposed animals revealed epithelial and endothelial cell swelling, in terstitial edema, and alveolar type II cells depleted of lamellar bodies. These findings support the possibility that carbon monoxide intoxication is associated with increased alveolar-epithelial permeability.
Clindamycin phosphate was used in the treatment of 29 children with osteomyelitis of whom 25 had an acute and four a chronic type of infection. The usual dose was 50 mg/kg/day intravenously for approximately three weeks followed by oral clindamycin palmitate at home in a dose of 30 mg/kg/day for an additional six weeks. Staphylococcus aureus was isolated in 22 of 29 cases: 96% of strains were penicillin resistant. The clinical and bacteriologic results in the present series were good to excellent. There was prompt clinical and bacteriologic response shortly after initiation of clindamycin therapy. Good bone penetration of the drug was observed. Long-term evaluation revealed satisfactory clinical and roentgenographic progress in all patients. No diarrhea or manifestations of enterocolitis appeared in any patient in spite of high doses of the drug for intervals up to nine weeks.
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PURPOSE: To describe the spectrum of radiologic findings in crutch-induced axillary artery injury and the effects of its unique pathophysiology on diagnostic evaluation and treatment. METHODS: Three patients with axillary crutch-induced axillobrachial injury were studied angiographically and percutaneous intervention was performed in two cases. RESULTS: One patient required surgical bypass of a thrombosed axillary artery aneurysm. One patient responded to percutaneous transluminal angioplasty (PTA) of a focal axillary artery stenosis. One patient with an axillary artery aneurysm and distal thromboembolic disease was treated by both thrombolysis and surgical thromboembolectomy and later by PTA of an axillary artery intimal disruption. CONCLUSION: Chronic axillary crutch use may be associated with axillary artery stenosis, aneurysm formation, and secondary axillobrachial thromboembolic disease. Mural injury can be successfully treated by PTA and thromboembolic disease by thrombolytic therapy. Early identification of the axillary artery lesion is critical for long-term therapeutic results.
This study was conducted to determine if synthetic porcine gastrin-releasing peptide (GRP) stimulates the release of immunoreactive cholecystokinin (CCK), pancreatic polypeptide (PP) and gastrin in dogs. Three doses (0.01, 0.1 and 0.5 micrograms/kg-hr) of synthetic porcine GRP were administered intravenously to six conscious dogs. Synthetic porcine GRP stimulated the release of each hormone in a dose-related manner. The effect of GRP on the response of gastrin was greater than its effect on CCK and PP responses. This study indicates that the biological action of synthetic porcine GRP is similar to the bombesin, an amphibian peptide shown previously to stimulate the release of gastrointestinal peptides.