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Biomedical subjects

D McCarthy

Publications and source records attributed to D McCarthy.

At least 163 records · Page 9Linked to original sources

Signal probability, reinforcement and signal detection.

Five pigeons were trained to detect differences in light intensity. Two stimuli, S1 and S2, differing in intensity, were arranged on the center key of a three-key chamber according to set probabilities. A peck on the center key turned on the two side keys. When S1 was presented on the center key, a peck on the left key was "correct" and when S2 was presented, a peck on the right key was "correct." Correct responses produced reinforcement and incorrect responses produced 3-second blackout. Detection performance was measured under three procedures. The first was a standard signal-detection design in which the probability of S1 was varied and the number of reinforcements obtained for correct responses to S1 was allowed to covary. In the second procedure, the probability of S1 was again varied but the distribution of reinforcements between the two choices was kept equal. In the third procedure, probability of S1 was held constant while the distribution of reinforcements was varied between the two choices. Changes in response bias were a function of variations in the relative reinforcement ratio for the choice responses and not a function of variations in the probability of stimulus presentation. Discriminability remained constant across the three procedures.

Animals↗

Response to doxorubicin in hairy cell leukaemia.

A case of hairy cell leukaemia (HCL) treated by single-agent chemotherapy after the failure of splenectomy is reported. The patient was treated with doxorubicin 50 mg on 4 occasions over an 8-day period. After 2 weeks of profound pancytopenia, substantial blood and bone marrow improvement ensued. This case demonstrates that HCL may in some case be treated successfully by intensive chemotherapy.

Adult↗

Echocardiographic diagnosis of bacterial endocarditis of the mitral valve in a neonate.

A full-term normal neonate had acute staphylococcal endocarditis. Serial echocardiograms demonstrated abnormal echos in the region of the posterior mitral valve leaflet and aortic outflow tract that were subsequently proved to be a bacterial vegetation. This represents, we believe, the first case reported of the echocardiographic diagnosis of bacterial endocarditis in a neonate. There was progressive functional impairment of the mitral valve despite appropriate antibiotic therapy. At necropsy, a 1-cm vegetation was found attached to, and eroding through, the posterior mitral valve leaflet. The remainder of the heart, including the mitral valve apparatus, was normal. Endocarditis is a rare, but devastating, disease in a neonate, and the echocardiogram is a safe noninvasive method of making an accurate diagnosis and following the course of the disease.

Diagnosis, Differential↗