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Biomedical subjects

D Maurer

Publications and source records attributed to D Maurer.

At least 109 records · Page 6Linked to original sources

Newborns' discrimination of chromatic from achromatic stimuli.

Two experiments assessed newborns' ability to discriminate chromatic from achromatic stimuli. In Experiment 1, newborns differentiated gray from green, from yellow, and from red: For each of these hues they preferred chromatic-and-gray checkerboards over gray squares matched in mean luminance, even though the luminance of the gray checks was varied systematically over a wide range so as to minimize nonchromatic cues. However, newborns showed no evidence of differentiating gray from blue: At some luminances they showed no preference for a blue-and-gray checkerboard over a gray square. In Experiment 2, newborns differentiated red from gray but appeared not to differentiate blue from gray: Following habituation to a series of gray squares of varying luminance, they looked longer at a red square than at a gray square of novel luminance but showed no such pattern of recovery to a blue square. The results imply that newborns have some, albeit limited, ability to discriminate chromatic from achromatic stimuli and hence, that they are at least dichromats.

Adult↗

Preferential looking as a measure of visual resolution in infants and toddlers: a comparison of psychophysical methods.

We used preferential looking to estimate the monocular visual resolution of children 6-36 months old and compared results from 3 psychophysical methods: Taylor and Creelman's PEST staircase, our modification of the PEST procedure, and the method-of-constant stimuli. Estimates of visual resolution for 48 children tested with the original and modified PEST procedures and for 50 children tested with the method-of-constant stimuli and the modified PEST procedure showed excellent agreement across procedures, with the modified PEST procedure requiring the fewest trials and the least time. Results from the modified PEST procedure for 168 children with normal eye alignment and minimal refractive errors indicated that monocular visual resolution improves from 6.5 min at 6 months to 1.2 min at 36 months. Preferential looking combined with the shortened PEST procedure should be useful for testing the visual resolution of preverbal children with eye problems.

Child Development↗

Effects on perceptual development of visual deprivation during infancy.

We measured three aspects of vision in children treated for unilateral congenital cataract: visual resolution, the symmetry of optokinetic nystagmus (OKN), and peripheral vision. Good visual resolution was achieved by children who had had the earliest treatment and who had had the normal eye patched close to 50% of the waking time throughout early childhood. All children treated for unilateral congenital cataract showed a marked asymmetry of OKN regardless of the age of treatment. One child with early treatment who could be tested with the Goldmann perimeter also showed especially poor sensitivity in the nasal visual field of her aphakic eye. We found no such deficits in the vision of children who had had normal visual experience during early infancy and then later developed cataracts in one or both eyes. The limitations observed in children treated for congenital cataract are similar to those reported in normal human infants, in normal kittens, and in cats which were visually deprived early in life.

Adolescent↗

The development of young infants' ability to detect stimuli in the nasal visual field.

We compared infants' ability to detect single lines of varying width in the temporal and nasal visual fields. The smallest lines detected by 1-month-olds at 20 degrees in the nasal visual field were more than eight times wider than those detected at 30 degrees in the temporal visual field. In contrast, 2-month-olds detected smaller lines at 20 degrees in the nasal visual field than at 30 degrees in the temporal visual field. Converging evidence suggests that the observed improvement between 1 and 2 months in detection in the nasal visual field reflects the maturation of a projection from the retina through the visual cortex to the superior colliculus.

Eye Movements↗

The scanning of compound figures by young infants.

We studied infants' scanning of two compound stimuli, in each case by presenting features inside a frame, the frame alone, and the features alone. One stimulus was composed of squares and was like that studied by P. Salapatek (in L. Cohen & P. Salapatek (Eds.), New York: Academic Press, 1975); the other was a schematic face. Newborns and 1-month-olds looked at the small square when it was presented alone, but rarely looked at it when it was framed by the larger square. In contrast, 2-month-olds looked at the small square for long periods whether or not it was framed. However, when newborns and 1-month-olds were shown a schematic face, they looked at its internal features at least half the time. Thus, young infants show no external bias when scanning a schematic face.

Age Factors↗

Effects of chemical mediators of anaphylaxis on ciliary function.

We assessed the effects of selected chemical mediators of anaphylaxis on CBF in vitro. Ciliated epithelial cells were obtained from the trachea of conscious sheep with a cytology brush and suspended in a perfusion chamber containing KH. Ciliary activity was viewed microscopically and recorded on videotape for subsequent slow-motion analysis of CBF. Prostaglandin E1 (10(-8) M to 10(-6) M), prostaglandin E2 (10(-10) M to 10(-6) M), and leukotriene-C4 (10(-8) M) increased CBF between 7% and 33%. Histamine caused ciliostimulation only at the relatively high concentrations above 10(-5) M (7% increase in CBF), whereas prostaglandin F2 alpha (10(-10) M and 10(-6) M) was without effect. In no preparation was ciliary discoordination observed. These findings indicate that several chemical mediators of anaphylaxis stimulate CBF and that the previously described impairment of mucociliary transport in stable allergic asthma or antigen-induced bronchoconstriction is probably not caused by a primary alteration of ciliary function.

Alprostadil↗

Peripheral vision and optokinetic nystagmus in children with unilateral congenital cataract.

The vision of cats which were monocularly deprived during early infancy, of kittens, and of young human infants shares two limitations: detection in the nasal visual field is far poorer than detection in the temporal visual field, and optokinetic nystagmus (OKN) is difficult to elicit when a pattern moves nasally to temporally. Here we report similar limitations on the vision of children who had a dense central cataract in one eye during early infancy. Extensive static perimetry with one of these children whose visual acuity was good in both eyes revealed that her threshold for detection all along the horizontal meridian was higher in her aphakic than in her normal eye, with this difference much more pronounced in the nasal visual field than in the temporal visual field. Three children who developed cataracts after 6 months of age showed no such discrepancy between thresholds in the temporal and nasal fields. We tested the symmetry of OKN in 12 children treated for unilateral congenital cataract. In every test of an aphakic (n = 4) or normal eye (n = 12), OKN occurred significantly more often when stripes moved temporally to nasally than when they moved nasally to temporally. In contrast, no asymmetry was observed in any of 13 children treated for traumatic cataracts incurred after 3 years of age. We conclude that children treated for unilateral congenital cataract, like young human infants and monocularly deprived cats, show asymmetric OKN and relatively poor detection in the nasal visual field.

Animals↗

The development of the kitten's visual field.

We tested the monocular visual field of 16 kittens aged 13-56 days, by observing their unreinforced visual orienting. At 13-14 days the kittens oriented toward stimuli out of 45 degrees in the nasal field. Until 7-8 weeks, performance was significantly poorer in the nasal field than in the temporal field. This delayed development of the nasal field may be related to the relatively slow development of the uncrossed retino-geniculate projection and of the pathway through the visual cortex to the superior colliculus.

Aging↗

Infants' perception of natural and distorted arrangements of a schematic face.

The techniques of visual preference and of habituation were used to test the ability of 1- and 2-month-olds to discriminate various arrangements of the features of the human face. We showed infants schematic drawings of a human face with the features (1) arranged naturally, (2) arranged symmetrically but scrambled, and (3) arranged asymmetrically and scrambled. 2-month-olds discriminated among all 3 arrangements; 1-month-olds appeared not to discriminate between any of them 2-month-olds also showed a preference for a natural arrangement of the features, but 1-month-olds did not. Thus, by 2 months infants may recognize how the features of a natural human face are arranged and generalize that knowledge to schematic faces.

Discrimination Learning↗

The perception of facial expressions by the three-month-old.

We used habituation to investigate 3-month-olds' abilities to discriminate and recognize smiling and frowning expressions posed by the mother or by a female stranger. Infants discriminated between the expressions and recognized which expression they had seen during the habituation trials; they did so whether the expressions were posed by the mother or by the stranger. However, when the expressions were posed by the mother, more infants showed the discrimination, and boys looked at her pictures longer than girls. These differences suggest that infants' previous experiences with faces influence their perceptions of the facial expressions.

Affect↗

Prenatal diagnosis of congenital adrenal hyperplasia (21-hydroxylase deficiency) by HLA typing.

Congenital adrenal hyperplasia (C.A.H.) due to 21-hydroxylase deficiency is an HLA-linked recessive disorder. HLA-A and B antigens are expressed on amniotic cells. Prenatal diagnosis of C.A.H. by HLA typing of families and amniotic cells was attempted in two at-risk families. In one family HLA typing indicated that the fetus would have C.A.H., and this prediction was confirmed after birth. In the second family, HLA typing indicated that the fetus would be an unaffected, phenotypically normal carrier of the disease gene, and this prediction was also confirmed after birth.

Adrenocortical Hyperfunction↗

Sensitivities of radioimmunoassay and enzyme-linked immunosorbent assay for detection of hepatitis B surface antigen.

Radioimmunoassay (RIA) using Austria II (Abbott) was found to be more sensitive for the detection of HBsAg than the Hepanostika Micro-Elisa system (Organon Teknika), by a factor of 5- to 20-fold for subtype 'ad' (with one exception), and 2- to 5-fold for subtype 'ay'. The sensitivities of RIA and the enzyme-linked immunosorbent assay (Elisa) have also been evaluated in the screening of 178 selected serum samples contributed by 7 different laboratories. Of these, 149 were found to be positive for HBsAg by RIA, 142 were positive by Elisa and 36 were positive by CEP.

Blood Donors↗

[Development of bacterial populations of telluric, enteric, and marine origin in planktonic systems exposed to urban pollution; mathematical data analysis].

A study of the comparative distribution of different types of bacterial populations in the sea area where the city of Marseille rejects its waste water shows that, when in contact with the marine environment, a great part of the allochthonic bacterial population undergoes physiological stress expressed by an abrupt reduction of the effectives and by weak values of the energetic charge. The presence of coliforms and streptococci in waste water lens, at important distances from discharging conduits, shows the possibility of a large diffusion for a fraction of the bacterial populations that withstand the initial stress. From mathematical analyses, an inverse correlation is revealed between detergents and the bacterial population as a whole, and between phenols and various allochthonic bacterial populations. The above results were evidenced through a sampling strategy based upon a 24-h-cycle study and a search for mathematical correlations between several biological, chemical, and physical parameters.

Adenosine Triphosphate↗