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Biomedical subjects

D Marsh

Publications and source records attributed to D Marsh.

313 records · Page 18Linked to original sources
PubMedDate not supplied

Lipid-protein interactions and heterogeneous lipid distribution in membranes.

The specificity of lipid interactions with both integral and peripheral proteins is discussed in terms of the microscopic heterogeneity in lipid distribution to which they give rise. The factors giving rise to macroscopic phase separation, namely hydrophobic mismatch for integral proteins and phase transitions for lipid bilayers, also are considered. Simple thermodynamic or phenomenological models are given for the way in which specific lipid interactions with peripheral or integral proteins may be coupled to intrinsic lipid phase transitions and thus enhance the phase separation or domain formation of the lipid.

Mathematics↗
PubMedDate not supplied

Effects of domain structure on in-plane reactions and interactions.

The existence of an in-plane domain structure in biological membranes raises the question of the physiological function, if any, of this structure. One important function may be to enhance or limit the equilibrium poise and rates of in-plane reactions through control by the cell of the percolation properties of the domain system. At low average domain occupancy by reactants or interactants, which must be the case for most biological membrane components, moving the domain system from connection to disconnection has marked effects on the apparent equilibrium poise and the rates of membrane-confined reactions. This conclusion is based on computer modelling of the effects of disconnection/connection of nine types of bimolecular in-plane reactions. Using the phase structure and percolation properties of two-component, two-phase phospholipid bilayers, it is possible to examine experimentally homo- and heterodimerization reactions, and enzyme-catalysed reactions in-plane as well as the effects of a transmembrane peptide on these systems. These theoretical and experimental studies suggest that percolation effects may be physiologically important in biological membranes. Whether this is in fact the case remains to be demonstrated.

Biophysical Phenomena↗
PubMedDate not supplied

Using the Web to develop an EN conversion course.

This article describes the use of a web-based environment to develop a modularised enrolled nurse (EN) conversion programme. It details the development process and the reasons for choosing a web-based environment for the programme. In the age of multimedia developments, sharing the processes and the problems encountered will benefit those who access future programmes.

Attitude of Health Personnel↗