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Biomedical subjects

D Marchesoni

Publications and source records attributed to D Marchesoni.

At least 55 records · Page 3Linked to original sources
PubMed1983

Clinical staging versus operative staging in cervical cancer.

The Authors analyse the correlations between clinical staging (FIGO) and surgical staging in 152 patients affected by cervical cancer who underwent primary surgical therapy at the Gynecologic Institute of Padua University between 1974 and 1982. In the examined series clinical staging agrees with surgical staging in 2/3 of cases. The error percentage of clinical staging does not change significantly, from a statistical point of view, when staging varies. In those cases in which the two systems disagree the overstaging figure tends to decrease as staging becomes more severe while the clinical understaging figure tends to increase accordingly. On the basis of these results the Authors advocate a rational resort to operative staging in cervical cancer so as to evaluate the real topography of the original focus more accurately and plan the most adequate treatment.

Female↗
PubMed1983

Prognostic factors in cervical carcinoma.

Primary surgical treatment in cervical carcinoma offers an unrepeatable chance to assess the biologic characteristics of the neoplasia by surgical staging and pathologic examination of the surgical specimen. The detection of factors of risk for locoregional diffusion, clinical staging being equal, can guide a subsequent target radio-treatment by identifying a group of patients at higher risk for relapses. The analysis of 155 cases of cervical carcinoma treated with radical primary surgery and pelvic lymphadenectomy at the Gynecologic Institute of Padua University has stressed the statistically significant correlation (P less than 0.05) existing between lymphatic diffusion and presence of neoplastic cells in capillaro-like spaces, degree of neoplastic cervical infiltration and parametrial diffusion. According to the Authors the presence of these features is a reliable basis to select patients eligible for post-surgery radiotreatment.

Carcinoma↗
PubMed1983

Role of second look laparotomy in multidisciplinary treatment and in the follow up of advanced ovarian cancer.

Surgical re-examination after first line surgery followed by chemotherapy is an absolutely necessary step in the course of integrated treatment of advanced ovarian epithelial tumours. Our personal experience of surgical re-staging and reductive surgery in 48 patients affected by ovarian tumours stage III and IV (FIGO), by laparotomic second look is reported. Repeated surgery succeeds in further reducing the neoplastic deposits or radicalizing the first intervention in 33% of the overall series; in 52% of the cases, the second look was negative for neoplasia; in 16% only, despite tumour finding no reductive surgery was possible. If only the cases presenting residual neoplasia after primary surgery are taken into account, tumour debulking was possible in 44% of the patients. The analysis of this series fully confirms the preliminary statement that the smaller the residual neoplasia after surgery, the greater the chances of success for chemotherapy in ovarian cancer. It confirms as well that the laparotomic second look is the only currently available way to usefully assess the full remission of the disease.

Carcinoma↗
PubMed1983

Role of computed abdominal tomography (C.A.T. Scan) in the follow up of ovarian tumors.

This study evaluates the possible use of computed tomography not as an alternative diagnostic method but, rather, as a supplement to laparotomy in patients treated for ovarian cancer. The following conclusions can be drawn: in patients presenting no clinical evidence of persistent or relapsing disease C.T. Scan is not a mandatory but, rather, an optional test since it entails 25% false negatives, a 66.6% predictive value and because the involved patients will need, in any case, a further intervention. Conversely, C.T. Scan is clearly indicated in patients presenting clinical evidence of disease. It can prove helpful in detecting metastases in areas that prove difficult to be clinically examined; in assessing whether the retroperitoneal areas conceal neoplastic tissue or in planning the right operation for masses that have been palpated only before chemotherapy, and then in regression. When, despite chemotherapy, tumour progresses, surgery may became useless, and the C.T. Scan may therefore prove helpful in defining the condition and guiding non surgical treatment. Therefore, in the follow up of ovarian cancer the C.T. Scan may be performed on the basis of clinical course, instead than on a rigid aprioristic planning.

Cyclophosphamide↗
PubMed1982

What are the most suitable fetoplacental tests in the monitoring of the third trimester of pregnancy?

The case-series of the Institute of Obstetrics and Gynaecology were examined to evaluate the suitability of urinary estriol, total plasma estriol, unconjugated plasma estriol, unconjugated plasma estetrol, plasma placental lactogen, plasma S.P.-1 glycoprotein, plasma alphafetoprotein and biparietal diameter in correctly forecasting the perinatal risk, when performed after the 25th week of pregnancy. In high-risk pregnancies, according to our results, S.P.-1 glycoprotein and urinary estriol are the most sensitive tests, while S.P.-1 glycoprotein, placental lactogen and biparietal diameter are found to have the highest predictive value. The repetition of the considered tests increases their sensitivity, but not their predictive value. In pregnancy mass screening the most suitable tests, on the basis of the "relative risk" are S.P.-1 glycoprotein (or even placental lactogen), estriol and biparietal diameter. For the last one a single measurement seems to be enough during the third trimester.

Estetrol↗
PubMed1982

Use of intramyometrial injection of prostaglandin F 2 alpha in the management of intractable hemorrhage due to uterine atony.

Prostaglandin F2 alpha, in doses varying from 1 to 5 mg was injected transabdominally, transvaginally or intraabdominally (during caesarean section) into the myometrium in ten patients affected by metrorrhagias not responsive to conventional uterotonic drugs. In all cases but one the result was excellent. Important side effects were observed in only one patient, because of the inadvertent intravascular injection of 5 mg Prostaglandin into the endocervix. An adequate treatment of this patient brought her to complete recovery in a short time. According to our experience, the intramyometrial injection of PGF2 alpha, in doses varying from 1 to 2 mg, is a simple, safe and effective method in the control of severe hemorrhage due to uterine atony not responding to conventional treatment.

Adolescent↗
PubMed1982

Total and unconjugated plasma estriol. A comparison.

Total and unconjugated plasma estriol levels from the 24th to the 40th gestational week in 161 normal and 44 pathological pregnancies were studied. A lack of correlation between the two fractions was observed at the different gestational ages, probably due to the different rates of the several metabolic steps which condition the levels of the hormone fractions also in quite physiological conditions. The onset of pregnancy complications further modifies the ratio between the two fractions, as they differently affect the single metabolic processes which are essential for estriol to be produced, conjugated, recovered and excreted. E.P.H. gestosis and poor intrauterine fetal growth can be better diagnosed by the assay of total than unconjugated estriol: the total fraction proved to have the higher sensitivity, predictive value and relative risk and should therefore be preferred for pregnancy monitoring, as it better corresponds to the clinical situation.

Estriol↗
PubMed1982

Clinical re-staging in cervicocarcinoma after clinico-instrumental staging.

A review of 193 cases of invasive carcinoma of the cervix was undertaken to determine the efficacy of the procedures used in the staging of this disease. All patients underwent pretreatment chest, pelvis, and spine radiographies, intravenous pyelogram, cystoscopy and proctoscopy. Bone scanning was performed too. These patients were retrospectively staged according to findings of the physical examination only. Each additional examination was then evaluated comparing its results with the initial staging. The column Xray did never change the stage; the other radiologic examinations changed the staging as follows: chest Xray 0.5%, pelvis 1%, intravenous pyelogram 2%. Cystoscopy and proctoscopy changed the clinical stage in 5.1% and 2.5% of the cases, respectively. Bone scanning in 1.5%. A review of 54 selected cases was undertaken to determine the presence of positive nodes in patients with carcinomas at stages I and II. In 16 cases of cervicocarcinoma the hystologic examination showed positive pelvic lymph-nodes. The AA, recommend all the reviewed procedures in the staging of carcinoma of the cervix in initial stages too.

Carcinoma↗
PubMed1982

Diagnosis and treatment of preinvasive and microinvasive cervicocarcinoma.

The mortality rate of cervicocarcinoma has significantly decreased over the last few years, thanks to early diagnosis. Prophylactic and therapeutical interventions, at different stages, are therefore necessary to eliminate or, at least, decrease the incidence of this pathology. Between 1975 and 1980, during a cytologic depistage carried out at the Institute of Gynecologic and Obstretic Clinic of Padua University, we examined 72 cases of patients who had undergone the following diagnostic iter: colposcopy, cytology, direct biopsy and conization. Various parameters were analyzed, notably with regard to cases of serious dysplasia, carcinoma in situ, neoplasia with beginning invasion of the glandular necks and microinvasive forms.

Adult↗
PubMed1982

Hormonal profile following total abdominal hysterectomy and bilateral salpingo-oophorectomy in post-menopausal endometrial carcinoma.

The Authors report the results of study carried out on ten post-menopausal patients affected with endometrial carcinoma (FIGO stage I & II) who underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH & BSO). Estradiol, Testosterone and Prolactin plasma levels were assayed before surgery and in the 2nd, 10th and 30th post-operative day. The evaluation of the data supports the opinion that in postmenopause Estradiol origin is mainly extraglandular and the ovaries produce Testosterone; the evaluation of Prolactin levels before and after surgery, at last, cannot rule out the hypothesis of an hypothalamo-pituitary disfunction in post-menopausal patients affected with endometrial cancer.

Aged↗
PubMed1981

Mathematical-statistical evaluation of hypophyseal and ovarian response to Gn-RH and to D-Leu6-des Gly10-LH-RH-EA stimulation in patients with amenorrhea.

In a group of 30 women with secondary amenorrhea the administration of D-Leu6-des Gly10-LH-RH-EA Analogue 25 mcg i.m. leads to a more intense and prolonged gonadotrophin response than synthetic Gn-RH 100 mcg i.v. The ovarian response to Gn-Rh is remarkable and lasts for approximately 24 hours; the stimulation with Analogue leads to a response which is slightly more intense than the one induced by Gn-RH, but probably of longer duration.

Adolescent↗
PubMed1981

GnRH--test in menopause. Its possible use in identifying the subjects at risk for dysplastic endometrial pathology.

The Authors, after reviewing the results of their previous studies on the endocrine situation in post-menopausal endometrial carcinoma and considering what emerges from the present work, suggest GnRh-Test as a mean to better identify the subjects at risk for this neoplasia; in patients already affected with endometrial cancer, it could be an indirect index in recommending or not endocrine therapy.

Aged↗
PubMed1981

"Euthyroidal' goiter and menstrual disorders.

We selected 5 patients, between 18 and 31 years of age, presenting menstrual irregularities and thyroidal goiter with no apparent functional change (normal, T4 and T3 tests). These patients underwent further examinations: TSH (basal and after TRH stimulation), HPRL (basal-circadian rhythm and after TRH stimulation), FSH and LH (basal and after Gn-RH stimulation), thyroidal scintiscan, search for antithyroid antibodies. Basal and post-stimulation TSH was fundamental in 2 cases of subclinical hypothyroidism. The positive antibody search confirmed the antoimmune origin. In the same patients, the HPRL circadian rhythm and TRH test highlighted a secondary hyperprolactinemia which would not have been revealed by a single basal sample.

Adolescent↗
PubMed1981

Fibrinogen degradation products (F.D.P.) in ascitic fluid of patients affected by ovarian cancer.

Ascitic fluid samples from 10 patients with ovarian carcinoma and 10 with cirrhosis of the liver were examined for their content of components of the fibrinolytic system. Large amounts of fibrin/fibrinogen degradation products (F.D.P.) were found in the ascitic fluid in all patients with malignant tumors, but not in the other group. Determination of F.D.P. may therefore make it possible to differentiate between malignant and non-malignant ascitic fluid.

Ascitic Fluid↗
PubMed1981

Bromoergocriptin therapy in eumenorrhoic patients presenting galactorrhea.

Eleven eumenorrhoic patients presenting galactorrhea were subjected to a three-month Bromoergocryptin therapy (2.5 mg/os/die). Prolactin Circadian Rhythm, performed on all patients, showed four hyper and seven normoprolactinemic cases. The mammary condition was studied, before and after treatment, through clinical examination, mammary cytology and thermography. Hyperprolactinemic patients responded positively to the therapy, showing subjective, clinical and thermographic improvement. Conversely, normoprolactinemic patients, though showing a noteworthy improvement of symptomatology and galactorrhea, did not respond equally well from the objective and thermographic points of view.

Adult↗