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Biomedical subjects

D Manzey

Publications and source records attributed to D Manzey.

22 records · Page 2Linked to original sources
PubMed1985

Delineation of pharmacopsychological effects by means of endogenous event-related brain potentials: an exemplification with flupentixol.

A new experimental paradigm for studying cognitive functions by means of endogenous event-related brain potentials is presented. The paradigm has the following characteristics: (1) subcomponents of 'P300' (P3a, P3b, positive slow wave) and subcomponents of 'CNV' (early and late wave) are separated in time; (2) probability effects known to work on P300 subcomponents are completely under experimental control; and (3) psychologically defined antecedent conditions which affect particular endogenous components can be manipulated precisely and independently of each other. The usefulness of the paradigm for monitoring pharmacopsychological effects on cognitive functions is exemplified by means of flupentixol (Fluanxol 0.5). Reliable drug effects were observed with a dosage of 2 mg/day after 4 days of treatment. The results can be taken as evidence that flupentixol has an impairing effect on human information processing resources; in particular functions related to motor preparation, perceptual analysis, and memory retrieval are affected.

Adult↗
PubMed1981

Principal components and varimax-rotated components in event-related potential research: some remarks on their interpretation.

Some properties of principal components analysis (PCA) and simple structure rotation, which are relevant to the study of event-related potentials (ERPs), were examined both in theory and with simulated data. The analysis casts some doubt on whether it is useful and desirable to rotate the loading pattern of a PCA of ERPs to simple structure. The evidence presented is more in favour of the unrotated solution. In particular we were able to demonstrate with simulated data that a solution rotated to simple structure may lead to false conclusions about the functional independence of ERP peaks. Beyond this, the more general question is asked of whether principal components should be accepted as basic waveforms, i.e. as physiologically meaningful entities which, for example, represent different ERP generators.

Contingent Negative Variation↗