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Biomedical subjects

D Mancia

Publications and source records attributed to D Mancia.

93 records · Page 6Linked to original sources

[Epilepsy in later life: seizures persisting after the age of 60].

In a group of 657 epileptic patients there were 51 presenting with fits even after having reached the age of 60. The onset of seizures dated back to the first 20 years in 15 patients between 20 and 40 years in 15 and between 40 and 60 years in 21. In 67% of the cases it was possible to determine the cause of seizures. The aetiology was unevenly distributed within each group. In the first group (up to 20 years) the P.G.E. forms prevail. In the second (up to 40 years) post traumatic epilepsy and inflammatory processes were predominant, while in the third (up to 60 years) vascular and tumoral pathology seem to be prevalent. 43% of the patients showed paroxysmal abnormalities in the EEG and these were still present even after to age of 60 years in more than fifty per cent. After the age of 60 we found no case of benign epilepsy amenable to complete recovery. Patients older than 60 present epilepsies of mild severity. In symptomatic epilepsies the lesional factors were not subject to evolution and the epileptogenic focuses were stable and persistent. In partial epilepsy there were more cases of complex symptomatology (86%) than cases of elementary symptomatology (14%) The evolution of seizures in old age is considered together with the importance of all factors influencing recurrency.

Adolescent↗

[Barbexaclone in the treatment of the epilepsies (author's transl)].

Chronic administration of barbiturates in the treatment of the epilepsies causes sedation. The association of C.N.S. stimulant agents appears to offer a possible advantage. 19 epileptic outpatients were followed up during an "open" trial of barbexaclone (L-1-cyclohexyl-2-methylaminopropan-phenyl-ethyl-barbiturate) over a period of about one year. The drug was effective in primary and secondarily generalized epilepsies, and to a lesser extent in partial complex seizures. The tolerability was good and a reduction of the side-effects due to previous treatment with phenobarbitone has been noticed. The mean dosage of barbexaclone was lower in patients who improved than in those who remained unchanged.

Adolescent↗

The masseteric inhibitory reflex in the diagnosis of multiple sclerosis.

In order to evaluate the reliability of the masseteric inhibitory reflex (MIR) as a screening method in the diagnosis of multiple sclerosis (MS), a series of 41 consecutive patients affected by clinically defined, long-duration forms (mean duration 10.9 years) of the disease was examined. In all cases magnetic resonance imaging and CSF isoelectrofocusing confirmed the diagnosis. Sensitivity of MIR, Blink Reflex and BAEPs were compared. Statistical analysis of data suggested the following considerations: 1) a significant concordance was found between MIR and the other neurophysiological tests performed (MIR vs. BAEPs in 78.4% of cases, p < 0.001; MIR vs. blink reflex in 68.3%, p < 0.02). 2) The S1 early component of MIR is a more reliable indicator than S2 late component. 3) In detecting brainstem lesions the sensitivity of MIR equaled that of the other neurophysiological tests. 4) Poor localizing concordance between neurophysiological tests and neuroimaging was found in our series. A possible utilization of MIR, as a part of a multimodal neurophysiological approach, even in patients affected by possible or probable MS is suggested.

Adult↗