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Biomedical subjects

D Mancia

Publications and source records attributed to D Mancia.

At least 19 recordsLinked to original sources
PubMed1992

Acute sensory and autonomic neuropathy: possible association with coxsackie B virus infection.

This report describes a 26 year old woman with a Coxsackie B virus infection complicated by an acute pandysautonomic and sensory neuropathy. Electrophysiological studies suggested an axonal neuropathy. A sural nerve biopsy performed early in the disease showed axonal degeneration with a virtual absence of unmyelinated fibres and moderate loss of myelinated fibres, mainly affecting the small fibres; this differs from previous reports. An immune-mediated or direct virus action might explain the pathogenesis of this unusual evolution of a viral infection.

Adult↗
PubMed1979

Possible interference between migrainous and epileptic mechanisms in intercalated attacks. Case report.

The possibility that epileptic seizures and classic migraine episodes may occur in the same patient is discussed. The probable relationship between the neurophysiological mechanisms which underlie both types of attacks has not yet been agreed upon. The case of a young man who suffered from classic migraine and who presented two convulsive epileptic attacks, preceded by visual aura is described. The EEG showed an epileptogenic occipito-temporal focus which corresponded to the region of the scotoma origin. A possible connection between scotoma in migraine and epileptic discharge is discussed. It is proposed that spreading depression, as the basis of the migraine prodomata, was preceded by a moment of intense neuronal excitation which changed the epileptic intercritical activity into a critical one.

Adult↗
PubMed1979

[Poligraphy during awakeness and sleep in patients with epilepsia partialis continua].

Report is made of two patients with Epilepsia Partialis Continua (E.P.C.) from brain organic damage (since carcinoma metastasis and localized ischemia). Clinical EEG, neuroradiological and anatomo-pathological and therapeutical problems are dealth with the light of a review on previous papers. The EEG by itself is assumed as a not sufficient neurophysiological mean. Long time poligraphic enregistrations during awakeness and sleep havae, on the contrary, produced interesting data. The continuous and localized more or less rhythmic myoclonus, which are the distinctive feature in the E.P.C., were in both the patients confined to the first two fingers of their hands; the more they decreased the deeper was sleep (phase II and III-IV) and almost disappeared in the REM phase. Thus poligraphic enregistrations for E.P.C. patients are maintained as very significant.

Adenocarcinoma↗
PubMed1978

[Experimental study on hepatic encephalopathy: EEG and blood amino acid findings].

The AA. describe a method of gradual occlusion of the portal vein in the rat to induce a hepatic encephalopaty. This method allows to realise a condition of hepatic ischemia and a portal hypertensive state accompanied by spontaneous portal-systemic shunts. These two factors produce a hepatic encephalopaty like in cirrhotic state or in patients after portal systemic anastomosis. A part from similar behavior at the beginning of the encephalopaty it is possible to define two classes of animals: one showing a slow recovery and one showing a transient and slight improvement followed at the end by the death of the animal. The AA. found a definite correlation amoung the clinica, EEG's, serum aminoacids and biochemical data. Probably the different anatomical and phisiological aspects of the induced portal systemic shunts and the different ways of hepatic rivascularization may determine the two different evolutions of the animals.

Amino Acids↗
PubMed1978

[Epilepsy and the driver's license].

143 older than 18 years epileptic patients have been considered under the concers of their driving licence. The 33,5% of them was already in hold it. Epilepsy was under different clinical forms. The majority of the subjects would suffer from generalized primary suizures, otherwise from partial fits, either elementar or complex. Subjects who already had the licence (37 over 75 men and 15 over 68 women) were presenting most scanty crisis, or since one year had non suffered from any at all. The frequency of crisis was very low for all the patients who had presented epilepsy before beingin permitted to drive; no question had been raised for them. Subjects without licence (25 men over 42 and 18 women over 53) had not been permitted to drive because of their illness. This group was mainly composed by patients either suffering from epilectic cerebropaty from very frequent fits, or from both. It is maintained as reasonable that italian laws conform to those within other E.E.C. countries for what concerns driving licence for epileptics; these patients, whether controlled, are assumed as well capable as accountable in mastering their condition, even when driving.

Adult↗
PubMed1977

[Petit mal status].

The historical evolution of P.M.S. nosography is pointed out, and his clinical features are exposed, mainly on the ground of the study performed by Lob and Coll., for the Tenth Marseilled Colloquium. Stress is laid upon the onset age of P.M.S., making reference to a review of 133 cases previously reported in the literature. Two paradigmatic cases are reported, selected between six P.M.S. observations we collected, and electroclinically investigated, from 1972 to 1975: a woman aged 34 who was suffering from P.M. and G.M. seizures since she was 12-years old, and also had some other P.M.S. episodes during past years; a woman aged 45 who suffered from a sudden P.M.S. attack, during a febrile illness: it seemed that it was the first occurrence, but an accurate catamnestic search suggested that previous P.M.S. manifestations had probably occurred during the infancy. Finally P.M.S. nosography is discussed for what concerns the variable features emphasized by our observations, the correlation between P.M. and P.M.S., and the problem of P.M.S. as the sole epileptic phenomenon.

Adult↗
PubMed1977

[Use of EEG response following intravenous diazepam administration in the etiologic diagnosis of brain lesions].

The authors take into consideration the reactivity of the E.E. Graphic focal anomalies to the i.v. infusion of 10 mg Diazepam. The cases includ 28 patients (15 with cerebral neoplasia, 8 with severe vascular accident, 5 with light vascular accident); among these, 19 showed typical E.E. Graphic focuses after administration of Diapezam, like those previously described by Weber and other Authors. Subjects with severe cerebral lesions and in the third age, after i.v. administration of 10 mg Diazepam showed vegetative disorders (hypotension, tachycardia or bradycardia, apnoea, periodic respiration). The reliability of the reactivity of the EEG focal anomalies to i.v. administration of Diazepam is confuted and the risks of such a methodology in subjects with severe cerebral damage or in the third age, are pointed out.

Adult↗
PubMedDate not supplied

[The problem of spinal myoclonus (author's transl)].

A case of the so called "spinal myoclonus" in a 71 year-old-man affected by lung carcinoma is reported. Clinical manifestations and comparison with similar previously described in literature induce to believe in the existence of a myoclonic syndrome, whose pattern seems to give support to the attribute of "spinal", at least as conventional term. An involvement of intercalated neurons is advanced as pathogenic ground. Anyhow, possible suprasegmental implications are also considered.

Aged↗
PubMedDate not supplied

[The not choreic neurological complications of rheumatic disease (author's transl)].

The authors discuss the importance of neurological complications of rheumatic disease, which differ from those of Sydenham's chorea: encephalitis; acute cerebral circulatory insufficiency of cardiovascular basis; thrombosis and cerebral haemorrhage; cerebral emboli; and vasculitis. The case of a 13 year old boy who presented with an acute cerebral episode during an active phase of rheumatic fever is described. The E.E.G. showed a right hemisphere disturbance with a slight involvement of the controlateral hemisphere. The cardiac evidence was indicative of a rheumatic carditis. The clinical progress and EEG were rapidly favourable. The possible pathogenetic hypotheses of this case are taken into consideration, and the authors suggest that one must suspect a rheumatic etiology when an acute cerebral syndrome is established in a child or a young adult with current or previous rheumatic fever.

Acute Disease↗
PubMedDate not supplied

[Evaluation of the EEG aspects of rheumatic chorea as related to the clinico-evolutive parameters of the disease].

E.E.G. features as presented by 20 patients of rheumatic chorea (15 females and 6 males, from 11 and up to 16 year old) are examined. Pathological patterns concerned 17 patients (85%); in three cases (15%) no characteristic E.E.G. enregistrations were found. Three types of pathological E.E.G. patterns are reckoned: A type (7 patients, i.e. 35%): increased amount of Posterior Slow Waves. B type (5 patients, i.e. 25%): conspicuous alterations of the alpha rhythm, and appearance of bursts of diffused, monomorphous, slow activities. C type (5 patients, i.e. 25%): inconstant outcoming by bursts, of 2--4 cycles sec. waves on posterior regions. No correlation can be established, on the ground both of E.E.G. features and clinical findings, neither between altered E.E.G. patterns and choreic movements severity, nor between localization of the former abnormalities over the scalp, and distribution of the latter. Yet, E.E.G. alterations, when present, are not to be ruled out, as they can be the demonstration of organical impairment and can give evidence about the course and recovering. To distinguish, in rheumatic chorea between clearly pathological, by the one hand, and "functional" by the other, E.E.G. features, is assumed as difficult, as subjects are in a range of ages in which cerebral biorhythms have not reached ultimate definition.

Adolescent↗
PubMedDate not supplied

[Epilepsy in the third age: seizures presenting after the age of 60 years (author's transl)].

In a group of 400 epileptic inpatients of the Neurological Clinic of Parma, 82 were over 60 years of age. Only 59 of them presented fits for the first time after the 60th year of age and in 78% of these, a definite anatomical damage could be demonstrated (neuroradiological investigations). One half of the epileptic syndromes with known etiology were thought to be related to cerebrovascular disease, but only few cases followed a stroke with persistent neurological symptoms. Intracranial space-occupying lesions were found to be the cause of epilepsy in 17% of cases. Partial epileptic seizures, secondarily generalized seizures, clinical signs of neurological damage, slow focal changes in the E.E.G. were the main features of this group of patients. In 22% of cases, miscellaneous causes were found: head injuries, exogenous intoxications due to accidental or iatrogenic ingestion, or alcoholic abuse. Relatively frequent were the seizures appearing in the course of degenerative or slow viruses induced encephalopathies. In 22% no demonstrable cause was found. Adequate follow-up may help us to discover etiological factors which at present are not obvious, but some form of idiopathic epilepsy with onset in this age range cannot be definitively ruled out. Only in 15% of cases interictal E.E.G. changes consisted in specific generalized or focal paroxysmal discharges (spikes, polyspikes, polyspike-and-wave). In about half of the cases the interictal E.E.G. failed to provide valuable informations, but an ictal E.E.G. could be obtained in 13 cases out of 59.

Adolescent↗