Cephaloridine is an antibiotic well known for its remarkable efficacy and absence of ocular toxicity. However four cases have been reported with severe ocular affect; a unilateral retinitis pigmentosa with extinction of the E.R.G. and total irreversible blindness has been noted in three cases after sub-conjunctival or intra-camerular injection of cephaloridine, one case showed a slight improvement. In an experimental study undertaken on rabbits no ocular toxicity has been noted during sub-conjunctival or intra-camerular injection whilst very low doses of intravitreous injection reproduce exactly the same facts as observed in man. These various studies give proof of the ocular toxicity of cephaloridine and involves particular caution in its utilizaiton for endo-ocular diseases.

Administration, Topical↗

PubMedDate not supplied

Ophthalmologic aspects of pituitary apoplexy.

Pituitary apoplexy is an acute hemorragic or ischemic infarction in pituitary adenomas. The incidence in our series was 6.5%. Clinical diagnosis can often be difficult as the patient is frequently unaware of an existing adenoma (seven out of 11 patients). Therefore, the classic features of the syndrome must be known. They include sudden headaches, impairment of consciousness, endocrinological disturbances and sudden visual deterioration or oculomotor palsies. In this retrospective study from 1987 to 1994 of 14 patients presenting pituitary apoplexy there were 11 cases with visual abnormalities. Oculomotor palsies were more common (82%) than chiasmatic impairment (54.5%) and often revealed pituitary adenoma. CT-Scan and MRI examinations led to diagnosis, and emergency treatment (surgical removal by rhinoseptal approach or less often medical treatment) generally led to a regression of visual disturbances.

Adolescent↗

PubMedDate not supplied

[Uselessness of electroretinogram for detecting retinal poisoning by synthetic antimalarials].

Authors present two cases of typical macular "bull's eyes" other APS treatment with subnormal electric answer. They evocate the poor sensibility of the different methods used to detect and follow these patients and propose a more sensible, easier and test accepted test: static perimetry within the 12 central degrees, once or twice a year.

Aged↗

PubMedDate not supplied

[Subretinal neovessels in diffuse retinal epitheliopathy].

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Adult↗