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D Malthieu

Publications and source records attributed to D Malthieu.

At least 19 recordsLinked to original sources
PubMed2005

[New treatment for orbital non-Hodgkin's lymphoma: 2 cases treated with rituximab].

INTRODUCTION: Orbital non-Hodgkin's lymphoma is a rare tumor whose diagnosis is often difficult. Treatment of latent lymphoma have been changing because of progress in immunotherapy. OBSERVATION: We report two patients treated with rituximab (antibody anti-CD20). Two women, 50 and 59 years old, presented low-grade, IE-stage lymphoma. One was conjunctival MALToma, the other was orbitopalpebral, type A, of WFC classification, follicular, with small cells. Immunohistochemistry showed a diffused marking for Ac anti-CD20. Both patients received intravenous rituximab as a first treatment in December 2000, 375 mg/m2, four injections per week. We did not note any major undesirable effects. Both have been in complete remission for 4 years. These patients continue to be followed up. DISCUSSION: Rituximab's efficacy has been proved mainly in follicular LMNH or in recurrent forms. The recurrence may be more frequent in MALT lymphoma. This medical treatment has low hematologic toxicity. CONCLUSION: Rituximab offers an alternative for low-grade lymphoma treatment that is well tolerated by the patient.

Antibodies, Monoclonal↗
PubMed2005

[Orbital non-Hodgkin's lymphoma: a retrospective study of 22 patients].

INTRODUCTION: Although the number of non-Hodgkin's lymphoma (NHL) cases continues to grow throughout the world, orbital NHL is still a rare tumor that is difficult to diagnose. The objective of our study was to analyze the different orbital NHLs diagnosed in our Ophthalmology Department during the last 20 years. MATERIAL AND METHODS: [corrected] We conducted a retrospective study of conjunctive-orbital lymphomas diagnosed in the Amiens Ophthalmology Department between 1982 and 2002. The pathological reports of 22 cases were investigated, notably the mode of onset, the clinical and radiological description, the diagnostic mode, pathological results, and the type of treatment provided for these tumors. RESULTS: Every NHL was type B. They were for the most part low grade in terms of malignancy, isolated, primitive, orbital and inactive. DISCUSSION: Insidious, slow-growing lesions are often found, and biopsy can be difficult. This may explain delayed diagnosis. The first differential diagnosis is inflammatory pseudotumor. Only a good biopsy can confirm the diagnosis of NHL. CONCLUSION: New immunohistochemistry and genetic diagnostic methods make it increasingly possible to screen for NHL, even if the clinical history can be misleading. Moreover, treatments that are more and more precisely targeted to the immunohistochemical type of NHL seem to be giving very promising results. Several studies are ongoing.

Aged↗
PubMed2000

Scleral ectasia as a complication of deep sclerectomy.

Nonpenetrating deep sclerectomy is a filtration surgical technique to treat glaucoma. A 12-year-old girl presented with chronic arthritis complicated with glaucoma secondary to a chronic uveitis. A sclerectomy without a collagen implant was performed for uncontrollable glaucoma with deterioration in visual function. Three weeks later, the patient had a rise in intraocular pressure and a scleral ectasia on the sclerectomy. The eye showed an area of scleral ectasia in the bleb as well as iris adhesion. Partial resection of the bleb after iris detachment led to poor anatomic and IOP results. The indications for deep sclerectomy must be carefully considered, especially in patients at a young age with this type of glaucoma.

Arthritis, Juvenile↗
PubMed1997

[Congenital pit of the optic disk in indocyanine green].

PURPOSE: Etiopathogeny of serous retinal detachment (SRD) in optic pits remains a mystery. Several hypotheses have been proposed that lead to different treatments based on the possible mechanisms which explain the occurrence of SRD. The literature data about fluorescein angiography mainly concern the angiographic aspects of the optic pit itself, and seldom the SRD. We have examined these fluorescein angiographic aspects of the SRD. Indocyanine cardiogreen video-angiography gives new information which question the last etiologic hypothesis. METHODS: Nine patients underwent a fluorescein angiography when the SRD was discovered. Indocyanine cardiogreen was performed in four patients. RESULTS: In 8 cases there was hyperfluorescence on the optic pit. In 7 cases in the peripapillar space of the SRD. In one of these cases, there was a leakage on the temporal margin of the optic nerve. In 8 cases in the SRD: we noticed a late minimal hyperfluorescence in the SRD but it already existed in the early angiogram. The SRD became hyperfluorescent in arterio-veinous retinal phase. In late phases we noticed a well-demarcated area of hyperfluorescence. CONCLUSION: These investigations have revealed a permeation problem on the blood-outer retinal barrier of the peripapillar space and above all from the edge of optic pit. This can have a prognosis value for SRD. The hyperfluorescence in SRD remains an enigma and does not allow, as we thought before, to confirm one of the etiopathogenic hypotheses. A better acknowledge of indocyane cardiogreen angiographic semiology will allow us to explain these aspects in the future.

Adolescent↗
PubMed1989

[Eales' syndrome and hypereosinophilia].

Authors report one case of a non typical Eales' disease associated to an hypereosinophily. None etiology was found nosology and physiopathology of Eales' syndrome and Eales' disease are still unclear. Main element of diagnosis is the discovery of a general pathology.

Adult↗
PubMed1989

[Spontaneous rupture of Bruch's membrane and transient macular hemorrhage in patients with myopia].

18 eyes of 14 pathologic myopia patients with lacker cracks have been studied during a mean follow up of 45 months by initial and final clinical and fluoroangiography evaluation. These lacker cracks happen early in the myopia degeneration evolution in young patients. The evolution is marked by transient coinlike macular hemorrhages without CNM detectable. Prognosis for the retention of central vision after macular hemorrhages resolution is good. It mainly depends of lacker cracks initial location if macular quite wrong, if intramacular, quite right. Development of CNM is an infrequent eventuality but must be systematically research by angio-fluorography after spontaneous macular hemorrhage resolution which usually occurs 4 or 6 weeks later.

Adolescent↗
PubMed1989

[Reticular macular dystrophy and Steinert disease].

We studied the macular lesions of 14 patients with myotonic dystrophy. 4 of them presented signs of reticula dystrophy of the macular pigmentary epithelium. We searched the association with other ocular modifications.

Adult↗