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Biomedical subjects

D Maclean

Publications and source records attributed to D Maclean.

81 records · Page 5Linked to original sources

Achilles tendon reflex in accidental hypothermia and hypothermic myxoedema.

The photomotogram (P.M.G.) of the Achilles tendon reflex was studied in 26 patients with hypothermia (rectal temperature 33.3 degrees C or less), 10 of whom also had myxoedema (serum protein bound iodine 2.8 mug/100 ml or less). No reflex could be elicited in eight (31%) of these patients, including three of those with myxoedema. Hypothermia increases both the contraction and the relaxation times of the reflex, the relaxation phase being particularly prolonged in those with myxoedema. In those patients from whom the reflex was elicited the ratio of the contraction time to the "half-relaxation time" in the P.M.G. was less than unity in six of the seven with myxoedema, and considerably greater than unity in eight of the 11 (73%) who were euthyroid. Thus, analysis of the Achilles tendon reflex P.M.G. correctly predicted the thyroid status in 14 of the 18 hypothermic patients in whom the Achilles tendon reflex was present (78%). The wider use of this rapid test of thyroid function would allow a more rational use of thyroid hormones in hypothermic patients and so lead to a better assessment of their value.

Achilles Tendon↗

Relation of early mononuclear and polymorphonuclear cell infiltration to late scar thickness after experimentally induced myocardial infarction in the rat.

This report describes the relationship between the intensity of early inflammation after acute myocardial infarction and the later thickness of the left ventricular (LV) scar. Histologic sections of hearts from methylprednisolone-treated (MP), cobra venom factor-treated (CVF), and untreated control rats that had been subjected to either 2 or 21 days of coronary artery occlusion were studied. In the rats examined at 2 days (n = 20 for MP, n = 16 for CVF, and n = 20 for controls), a semiquantitative inflammation score (1-4) was attributed to each infarct. Mononuclear (MN) cells were counted in 4 oil-immersion fields per section and polymorphonuclear (PMN) cells in 9 oil-immersion fields per section. In the rats examined at 21 days (n = 22 for MP, n = 22 for CVF, and n = 26 for controls), the thickness of the LV scar was measured every 1.6 mm along its circumference. Inflammation scores at 2 days were 3.5 +/- .6 for controls, 1.5 +/- .5 for MP, and 2.9 +/- .8 for CVF (p less than .05 among groups). The MN cells counted were 73 +/- 7 for controls, 47 +/- 5 for MP, and 61 +/- 9 for CVF (p less than .05 among groups). There was no difference in PMN infiltrate among groups. Scar thickness at 21 days were .9 +/- .1 mm for controls, .7 +/- .1 mm for MP, and .9 +/- .1 mm for CVF (MP compared to CVF and controls, p less than .01).(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

The incidence of first-dose hypotension with quinapril in patients with mild to moderate hypertension.

A total of 2242 patients with mild to moderate hypertension (diastolic pressure 95-120 mmHg) were randomised on a double-blind basis to receive a single dose of placebo, 5 mg quinapril or 10 mg quinapril. Patients were identified who: (a) met the blood pressure (BP) criteria for first-dose hypotension (sitting or standing systolic BP < 100 mmHg, or a fall in systolic BP > or = 20 mmHg on standing); (b) had symptoms suggestive of hypotension; and (c) met the BP criteria and had symptoms. In all three classifications there were no statistically significant differences between the incidences in placebo and combined active treatment groups, or between those in the two quinapril groups. No associated serious adverse events were reported. In the low-risk population studied, it would appear that the incidence of first-dose hypotension with quinapril is similar to placebo and is not dose-related.

Adult↗