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Biomedical subjects

D M Zuckerman

Publications and source records attributed to D M Zuckerman.

4 recordsLinked to original sources

Child abuse and failure to thrive: individual, familial, and environmental characteristics.

Similar theories of etiology have been postulated for child abuse and nonorganic failure to thrive (FTT). This study compared individual, familial, and environmental conditions in cases of child abuse to cases of FTT. Assessment of the mother's childhood home, supports, current living situation, attitudes toward her child, and child characteristics (such as temperament, social maturity, and complicating medical conditons) showed the groups to be remarkably alike. The major significant difference was that although both groups were poor, the abuse group was even more impoverished and lived in more crowded conditions than the families with a child with FTT. These data suggest a common etiologic context for different pediatric social illnesses and the need for a broad collaborative approach by pediatricians and colleagues in related disciplines.

Child Abuse

Zinc protoporphyrin level in blood determined by a portable hematofluorometer: a screening device for lead poisoning.

An inexpensive portable fluorometer has been designed which can be used to determine the concentration of zinc protoporphyrin (ZPP) in a drop of unprocessed blood deposited on a disposable glass slide. No volume measurement of the blood sample need be made. The instrument displays the ZPP level in micrograms per deciliter of blood accurately and reproducibly, automatically calibrating each determination by comparing the blood fluorescence with that of a stable dye. The instrument, which we call a hematofluorometer, is ideally suited for use in primary screening for childhood and occupational lead intoxication. It can be used by public health personnel after a few minutes of instruction. Comparisons of ZPP levels obtained with the use of the hematofluorometer with erythrocyte protoporphyrin levels obtained using accepted extraction methods are presented.

Adult

The hematofluorometer.

A portable filter fluorometer, the hematofluorometer--which utilizes "front face" optics, internal standards, and digital computation capabilities--has been specifically designed for the rapid (approximately 5 s) assay of erythrocyte zinc protoporphyrin in unprocessed blood. A small (unmeasured) drop of blood, such as is obtained from a finger puncture, is placed on disposable cover slip and inserted in the sample holder of the instrument. The operator pushes the holder of the instrument. The operator pushes the holder, which also holds the permanent blank and standard, into the instrument. Zinc protoporphyrin concentration is automatically and instantaneously computed and the value is displayed on a digital readout as micrograms of zinc protoporphyrin per deciliter of blood for some standard hematocrit. No calibration adjustment need be performed by the operator. The hematofluorometer is designed for "field" use as well as for laboratory assays.

Erythrocytes