Search PubMed⌕ Search

Biomedical subjects

D M Young

Publications and source records attributed to D M Young.

80 records · Page 5Linked to original sources
PubMedDate not supplied

Psychiatric morbidity in travelers to Honolulu, Hawaii.

To investigate the phenomenon of acute psychiatric decompensation in travelers, charts of all psychiatric-emergency patients with a history of recent travel involving time-zone changes were reviewed at a major medical center in Honolulu, HI. Charts of a control group with no history of travel were also reviewed. Significantly more travelers than controls showed symptoms of depression and mania (P < .012). East-bound travelers were significantly more likely to show symptoms of mania than controls (P < .001). In an eastbound-versus-westbound comparison, significantly more eastbound travelers showed symptoms of mania, whereas significantly more westbound travelers showed symptoms of depression (P < .05). These findings support the phase-advance hypothesis of depression. Psychosocial and biologic factors that may contribute to psychiatric decompensation in travelers are discussed.

Acute Disease↗
PubMedDate not supplied

Expression of heat shock proteins in a linear rodent wound.

Heat shock proteins (hsps) are ubiquitous and known to be expressed in all organisms. These stress proteins are likely to be induced in the wound environment and may play a critical role in the overall process of wound repair. Linear incisions were made in Sprague-Dawley rats. Serial skin biopsies were taken, the dermis and epidermis were separated and a protein lysate made. The expression of hsp 72, 47, and 32 were analyzed by Western blotting and immunohistochemistry. There were distinct patterns of expression of hsp 72, 47, and 32 in the wound. In unwounded dermis, there was no constitutive expression of any of the heat shock proteins studied. In the epidermis, there was constitutive expression of hsp 32 and 72, but not hsp 47. With wounding, all hsps exhibited increased expression both in the dermis and epidermis. These patterns of protein expression are suggestive of the individual heat shock proteins' molecular function, such as hsp 72's role as an indicator of cellular stress and injury, hsp 47's role in collagen synthesis, and hsp 32's role as an antioxidant.

Animals↗
PubMedDate not supplied

Species-specific in situ hybridization with fluorochrome-labeled DNA probes to study vascularization of human skin grafts on athymic mice.

The skin replacements presently used for wound coverage vascularize less well than do autologous split-thickness skin grafts. Understanding how autologous grafts vascularize can lead to methods to improve skin-replacement vascularization. Fresh human skin was grafted on athymic mice. Endothelial cells were stained by immunohistochemistry. Human and mouse cells were distinguished by in situ hybridization with fluorescent species-specific DNA probes. The number of mouse and human endothelial cells in the graft were counted. Initial vascularization of the graft is limited solely to anastamosis of severed ends of human vessels in the graft-to-mouse vessels in the recipient bed. Mouse endothelial cells gradually replace human endothelial cells in the graft. This demonstrates that initial vascularization of skin grafts is solely the result of inosculation rather than neovascularization. Skin replacements that contain vessels should vascularize like skin grafts, and methods to repopulate replacements with capillaries should be sought.

Animals↗
PubMedDate not supplied

West Nile virus infection in birds and mosquitoes, New York State, 2000.

West Nile (WN) virus was found throughout New York State in 2000, with the epicenter in New York City and surrounding counties. We tested 3,403 dead birds and 9,954 mosquito pools for WN virus during the transmission season. Sixty-three avian species, representing 30 families and 14 orders, tested positive for WN virus. The highest proportion of dead birds that tested positive for WN virus was in American Crows in the epicenter (67% positive, n=907). Eight mosquito species, representing four genera, were positive for WN virus. The minimum infection rate per 1,000 mosquitoes (MIR) was highest for Culex pipiens in the epicenter: 3.53 for the entire season and 7.49 for the peak week of August 13. Staten Island had the highest MIR (11.42 for Cx. pipiens), which was associated with the highest proportion of dead American Crows that tested positive for WN virus (92%, n=48) and the highest number of human cases (n=10).

Aedes↗