Search PubMed⌕ Search

Biomedical subjects

D M Williams

Publications and source records attributed to D M Williams.

At least 397 records · Page 22Linked to original sources
PubMed1975

Fibrous dysplasia.

Three cases of monostotic fibrous dysplasia of the cranial bones are presented. Several theories of the etiology of this uncommon condition are put forward and the relationship between monostotic and polyostotic fibrous dysplasia, Albright's disease, and hyperparathyroidism is examined. The difficulty in diagnosis and the ways they may present to the ear, nose and throat surgeon are discussed. It is suggested that conservative surgery is the best mode of treatment for maxillary or temporal lesions. However, ethmoid lesions, particularly when the optic foramen or base of skull are eroded, may need a neuro-surgical approach. The use of radiotherapy in any case is deprecated.

Child↗
PubMed1975

Leucocyte alkaline phosphatase as a marker of cell maturity: a quantitative cytochemical and autoradiographic study.

A sensitive and reproducible cytochemical technique for the demonstration of leucocyte alkaline phosphatase (LAP) has been evaluated. It produces a stable reaction product which can be readily quantified microphotometrically. In the circulating neutrophil polymorphonuclear leucocytes of rats the mean LAP levels measured in this way fluctuated only slightly from day to day. A highly significant correlation was demonstrated between LAP levels of neutrophils and their age, determined by isotope labelling with tritiated thymidine and by nuclear morphology. The correlation between the age of neutrophils and the complexity of their nuclear morphology has also been confirmed. The technique provides a useful tool for the study of leucocyte kinetics in disease states.

Alkaline Phosphatase↗
PubMed1975

Superoxide dismutase activity in copper-deficient swine.

These experiments demonstrate the dependency of cuprozinc superoxide dismutase activity in red cells and liver on an adequate dietary intake of copper. The superoxide dismutase activity in red cells decreased to 15% of control values and, therefore, these cells may be used as a convenient model for studying the physiologic consequences of free radicals

Animals↗
PubMed1975

The prognosis in aplastic anemia.

The biphasic shape of the survival curve of 99 patients with aplastic anemia suggested that there may be at least two subgroups of patients with this disease, one with a very short survival and another with a longer survival. Patients who survived for 4 mo or less after the first clinic visit (group A) were different from the patients who survived longer (group B) with respect to their modes of onset, sex, intervals from the onset of symptoms to first clinic visit, and initial hematologic values. These differences suggested that short survival could be predicted from data available at the first contact with the physician. From these measurements, a prognostic index could be calculated which was useful in identifying the patients in group A. Although this method of prognostication needs further testing, if validated, it may prove useful in selecting patients for therapeutic trials and could explain the divergent results in previous studies of androgen treatment of aplastic anemia. When our androgen-treated subjects were compared with subjects with a similar prognostic index who had not received androgens, a beneficial effect of androgen therapy on survival could not be demonstrated.

Anemia, Aplastic↗
PubMed1974

The role of superoxide anion radical in the reduction of ferritin iron by xanthine oxidase.

Superoxide dismutase exerted a pronounced inhibitory effect upon xanthine oxidase-mediated reduction of iron in ferritin, ferric chloride, or ferric ADP. Maximal inhibition was observed when the superoxide dismutase concentration was only about 1% of that found in normal porcine liver. These observations indicate that superoxide anion radical is an intermediate in the reduction of iron by xanthine oxidase in vitro but not in vivo.

Adenosine Diphosphate↗