Biomedical subjects

D M Vermeulen-Cranch

Publications and source records attributed to D M Vermeulen-Cranch.

9 recordsLinked to original sources

PubMed1992

A comparison of the effects of propofol and nitrous oxide on the electroencephalogram in epileptic patients during conscious sedation for dental procedures.

The influence of sedative doses of propofol or nitrous oxide on the electroencephalogram was studied in 11 mentally handicapped patients with treated epilepsy undergoing dental procedures. At one session, propofol was titrated to achieve conscious sedation. The mean (+/- SD) dose requirements were 5.5 +/- 1.1 mg.kg-1.h-1. In six patients, the electroencephalogram was unchanged during propofol administration. In three patients, there was a decrease in epileptic activity, and in two patients, paroxysmal discharges disappeared. At another session, nitrous oxide was administered by nasal mask. The mean (+/- SD) concentration of nitrous oxide needed was 43.6% +/- 4.8%. The electroencephalogram did not change in nine patients, whereas in two patients epileptic activity decreased. There were no clinical epileptoid or other adverse manifestations during any treatment or up to 48 h thereafter. The results of the present study suggest that propofol or nitrous oxide can be administered in subanesthetic doses for conscious sedation in mentally handicapped patients with treated epilepsy.

Adolescent↗

PubMed1991

Conscious sedation with propofol in dentistry.

Propofol by continuous intravenous infusion was used as an alternative to nitrous oxide/oxygen for conscious sedation in 19 patients undergoing out-patient dental treatment. Patients were either extremely anxious or mentally and/or physically handicapped. Propofol was administered by a syringe pump at an initial rate of 3 mg/kg/hour. During the procedure the infusion rate was adjusted to attain and maintain the desired level of conscious sedation. The mean time from starting the propofol infusion until reaching the required level of sedation was 11.5 (SD 3.5) minutes. The mean infusion rate was 3.6 (SD 0.65) mg/kg/hour. The average duration of the dental procedure was 55.9 (SD 18.8) minutes. Sedation was satisfactory in all but two patients. There were no side-effects. Recovery was rapid after stopping the infusion. It is concluded that propofol is an acceptable alternative to nitrous oxide/oxygen for conscious sedation in the dental surgery.

Adolescent↗

PubMed1991

[The history of pain control in dentistry in The Netherlands].

Pain control in The Netherlands used to be in the hands of surgeons. Dentists were not allowed to use any drugs which could have a general effect. In the Anglo-Saxon countries dentists and anaesthesiologists working together since 1846 have achieved a high standard of pain control. Anaesthesiology has been recognised in The Netherlands only since 1948. The advantages of a sequence of possibilities for pain control have since become available for dentistry in The Netherlands.

Anesthesia, Dental↗

PubMed1990

[Conscious sedation in dentistry using Propofol].

The results of a trial with Propofol for conscious sedation in mentally and/or physically handicapped and extremely anxious dental patients is presented. A continuous intravenous infusion of Propofol was chosen as a method of administration with slow and careful titration until the appropriate level of sedation was reached. Propofol with its favourable pharmacokinetic profile proved to be an excellent agent for conscious sedation in the mentally and/or physically handicapped and extremely anxious patients. The depth of sedation is easily and rapidly controlled by the rate of the infusion. The recovery was rapid, the patients were clear headed and devoid of any early and late postoperative sequelae.

Adult↗

PubMed1986