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Biomedical subjects

D M Tucker

Publications and source records attributed to D M Tucker.

87 records · Page 5Linked to original sources
PubMed1977

Discrimination and evocation of affectively intoned speech in patients with right parietal disease.

Patients with right parietal disease have disturbed comprehension of affective speech. Ability to discriminate affective speech (make same/different discriminations) and ability to repeat emotionally bland sentences with affective tones were tested in three groups of subjects--patients with right parietal dysfunction and neglect, conduction aphasics with left hemispheric lesions, and patients without intracranial disease. Patients with right parietal dysfunction performed significantly poorer than did aphasic controls on both a recognition and discrimination task. Patients with right parietal dysfunction also scored poorer on the evocative task than the nonaphasic controls.

Adult↗
PubMed1976

A case of mixed transcortical aphasia with intact naming.

Altholgh Lichtheim recognized that Wernicke's 'reflex arch' (primary auditory area, to Wernicke's area, to Broca's area, to primary motor area) was important for repetition, he recognized that other areas of the brain (for example, area of concepts or semantic area) must be important in comprehension and voluntary speech. He suggested that Wernicke's area (phonemic area) not only projected to Broca's area (as Wernicke suggested) but that it also projected to the area of concepts. A lesion of this latter pathway or in the area of concepts would produce a syndrome where repetition was intact but comprehension was impaired (e.g. transcortical sensory aphasia). Lichtheim also thought that the area of concepts projected directly to Broca's area and that voluntary speech was mediated by this pathway. Although Lichtheim's model could explain the mechanism underlying transcortical aphasia, his schema could not explain anomic aphasia. Unlike Lichtheim's schema, Kussmaul's schema suggested that the area of concepts projects back to Wernicke's area before projecting to Broca's area. With this schema, a patient with a hypothetical lesion which interrupted the pathway from the area of concepts to Wernicke's area (but did not interrupt the pathway from Wernicke's area to the area of concepts) should be anomic, with normal comprehension and repetition. In order for this latter schema to be plausible there should also be a lesion which interrupts the pathway from Wernicke's area to the area of concepts but does not interrupt the pathway which goes from the area of concepts to Wernicke's area. A patient with this hypothetical lesion should comprehend poorly; however, in spite of poor comprehension, naming and repetition should be intact. We report a patient who demonstrates poor comprehension with intact naming and repetition. This patient could also read aloud but could not comprehend written language. Not only could this patient name objects but he could demonstrate their use. These observations suggest that comprehension of written language is mediated by a different pathway than the recognition of visually presented objects.

Aphasia↗
PubMedDate not supplied

Topography of the N400: brain electrical activity reflecting semantic expectancy.

When subjects read an semantically unexpected word, the brain electrical activity shows a negative deflection at about 400 msec in comparison with the response to an expected word. In order to study the brain systems related to this effect we mapped it with a dense (64-channel) electrode array and two reference-independent measures, one estimating the average potential gradients and the other radial current density. With these measures, the event-related brain potential (ERP) begins at about 70 msec with the P1, reflecting bilateral current sources over occipitoparietal areas. A strongly left-lateralized N1 then follows, peaking at about 180 msec, accompanied by an anterior positivity, the P2. A separate posterior positive pattern then emerges that seems to repeat the topography of the P1. Next, at about 350 msec, the ERP for the congruous word develops a P300 or LPC, characterized by a diffuse positivity over the superior surface of the head and several negativities over inferior regions. This superior source/inferior sink pattern of the LPC is greater over the left hemisphere. In contrast, the ERP for the incongruous word in this interval displays the N400 as a period in which topographic features are absent. At about 400 msec the ERP for the incongruous word begins to develop an LPC, which then remains relatively symmetric over the two hemispheres.

Analysis of Variance↗
PubMedDate not supplied

MMPI indices in the identification of patients evidencing pseudoseizures.

Data are presented on the clinical utility of two Minnesota Multiphasic Personality Inventory (MMPI) indices, the Pseudo-Neurologic (Pn) Scale developed by Shaw and Matthews and the configural rule system developed by Wilkus et al. for the prediction of pseudoseizures. Particular attention is given to base rates, hit rates, and error rates in the analyses. Only the configural rule system was found to be of clinical value in ruling out the probability of pseudoseizures.

Adult↗
PubMedDate not supplied

Molybdenum target x-ray spectra: a semiempirical model.

A semiempirical model for generating molybdenum target x-ray spectra is presented. The model is an extension of a previous model developed by the authors for tungsten and takes into account the depth of production for both bremsstrahlung and characteristic x-ray photons. As in the previous work, the optimal model parameters were determined using nonlinear least-squares fits to experimental data. Good agreement between the two was obtained. By varying target angle, off-axis angle, and filtration in the model in accordance with the x-ray tube and geometry of interest, results consistent with tabulated spectra for different conditions have been obtained.

Models, Theoretical↗
PubMedDate not supplied

Semiempirical model for generating tungsten target x-ray spectra.

A semiempirical model for generating tungsten target x-ray spectra is presented. This model extends earlier work in two significant areas. First, both bremsstrahlung and characteristic x-ray production are assumed to occur at varying depths within the target. Second, optimal parameters for the model were determined from experimental spectra utilizing nonlinear least-squares techniques. As a result, good agreement is obtained between calculated and measured x-ray tube spectra and output for different target angles and a wide range of x-ray tube potentials. Such is not the case with previously published models.

Mathematics↗
PubMedDate not supplied

Differentiating the N3 and N4 electrophysiological semantic incongruity effects.

An event-related potential termed the N4 has been widely studied due to its sensitivity to semantic incongruity. A recent report (Nobre & McCarthy, 1994) indicates there is also an N3 component that is sensitive to semantic incongruity. To differentiate these two components, an existing data set with 65 electrode sites, 78 subjects, and 120 sentences was examined. Instead of the usual procedure of averaging over the stimuli within distinct categories for each subject, a new approach--averaging over subjects--was employed. In this item average approach, 120 averages (one per sentence) were produced. Correlational analyses indicate that the N3 is equally sensitive to cloze probability and sentential constraint. The N4, by contrast, is more sensitive to sentential constraint and less to cloze probability; it is also correlated with familiarity. We interpret these results as evidence that the N3 is more responsive to semantic fit whereas the N4 is more responsive to semantic expectancy.

Adult↗