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Biomedical subjects

D M Tait

Publications and source records attributed to D M Tait.

7 recordsLinked to original sources
PubMed1991

Treatment of metastatic para-aortic paraganglioma by surgery, radiotherapy and I-131 mIBG.

A patient with a malignant, functioning, aortico-sympathetic paraganglioma and a solitary bone metastasis causing paraplegia was treated by spinal decompression, irradiation of the metastasis, surgical excision of the primary tumour and systemic I-131 meta-iodobenzyl-guanidine (mIBG). Sixteen months after treatment there was no clinical, radiological or biochemical evidence of residual disease and neurological function was restored. The case supports the use of combined treatment incorporating mIBG in patients with metastatic neuroendocrine tumours which demonstrate mIBG uptake.

3-Iodobenzylguanidine↗
PubMed1990

Adjuvant chemotherapy for medulloblastoma: the first multi-centre control trial of the International Society of Paediatric Oncology (SIOP I).

Two hundred and eighty-six patients with medulloblastoma from 46 centres in 15 countries were treated in a prospective randomized trial designed to assess the value of adjuvant chemotherapy. All patients were treated by craniospinal irradiation. Those randomly allocated to receive adjuvant chemotherapy were given vincristine during irradiation and maintenance CCNU and vincristine, given in 6-weekly cycles, for 1 year. The overall survival was 53% at 5 years and 45% at 10 years. At the close of the trial in 1979, the difference between the disease-free survival rate for the chemotherapy and control groups was statistically significant (P = 0.005). Since then, late relapses have occurred in the chemotherapy arm and the statistically significant difference between the two groups has been lost. Although there is now no statistical difference between the two arms of the trial, a benefit for chemotherapy persists in a number of sub-groups; partial or sub-total surgery (P = 0.007), brainstem involvement (P = 0.001), and stage T3 and T4 disease (P = 0.002). A number of prognostic factors for medulloblastoma have emerged; sub-total resection, extent of disease and being male sex carry a poor prognosis.

Adolescent↗
PubMed1987

Thermal enhancement of radiation response: a growth delay study on superficial human tumour metastases.

In a quantitative study of 96 nodules in 10 patients, an enhancement of radiation response has been demonstrated following the addition of a single heat treatment 3-4 h after a single dose of radiation. Thermal enhancement ratios ranging from greater than 1.6 to 4.2 have been derived from growth-delay curves obtained by ultrasonic and caliper tumour volume measurements. Nodules subjected to heat and radiation regress more rapidly than those receiving radiation alone, with median tumour volume halving times of 15.5 and 70 days, respectively. The total volume reduction was greater in heated nodules and the nadir values were observed later compared with nodules receiving radiation alone.

Combined Modality Therapy↗
PubMed1986

Lhermitte's sign as a complication of cisplatin-containing chemotherapy for testicular cancer.

Lhermitte's sign is reported in 14 patients receiving chemotherapy for metastatic testicular cancer. In six patients the typical symptoms appeared during chemotherapy: in five patients within 1 month of treatment and in one patient at 2 months. The duration of symptoms ranged from 2 to approximately 8 months. No patient had received radiotherapy to the cervical or dorsal spinal cord. The complication is ascribed to cisplatin, the only drug common to all 14 patients.

Antineoplastic Combined Chemotherapy Protocols↗