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Biomedical subjects

D M Salisbury

Publications and source records attributed to D M Salisbury.

29 records · Page 2Linked to original sources
PubMed1981

Evaluation of image processing and presentation methods in thallium-201 myocardial scintigraphy.

Using a phantom to simulate the LAO 45 degrees thallium-201 myocardial image with a transmural infarct of variable detectability, thirteen methods of computer image processing are evaluated for a group of eight observers using receiver operating characteristics (ROC curves). Initial results using electrostatic hardcopy images clearly demonstrate that images with three applications of a nine point smoothing routine and 30% background subtraction, displayed with three cycles of the grey scale, produce significantly more accurate interpretation (P less than 0.001) than the raw data, or any of the other methods used. This method provides an overall increase in the diagnostic sensitivity for the group and does not introduce a false positive bias. Grey scale cycling provides effective contrast enhancement as does a colour scale presentation. Comparing images as processed above with similarly smoothed images presented with a fifteen colour level scale on a TV monitor, the diagnostic sensitivities are not significantly different and this method provides the optimum image evaluation in this study.

Computers↗
PubMed1980

Colonoscopic polypectomy in children.

Five children presenting with chronic and intermittent rectal bleeding were diagnosed as having colorectal polyps by fibreoptic colonoscopy performed under sedation. Three of the children had had barium-enema films reported on as normal. Eight polyps were seen, of which six were proximal to the sigmoid colon. All were removed endoscopically (one by proctoscopy, one by snare-intussusception) without complication. Colonoscopic polypectomy is a safe and efficient procedure in children, and colonoscopy may be regarded as first-line management in those with rectal bleeding.

Adolescent↗
PubMed1980

Acute onset of autistic features following brain damage in a ten-year-old.

We report the case of a 10-year-old boy who, following a prolonged period of unconsciousness, displayed severe eye-to-eye gaze avoidance, sensory inattention, and some other behavioral symptoms normally associated with the syndrome of infantile autism. The symptoms lasted only a few months and were associated with the more permanent behavioral changes of postencephalitic psychosis. Serial computerized tomography scans were taken during his illness and recovery. The relevance of this case to the etiology of infantile autism is discussed.

Atrophy↗
PubMed1979

Clinical events relating to intraventricular haemorrhage in the newborn.

Continuous measurements of arterial pressures, heart rates, respiratory movements, and respiratory rates were made from birth in 44 infants at risk from intraventricular haemorrhage (IVH). 17 babies died with IVH, in 10 of whom the event was timed objectively. Events in these babies were compared with survivors of similar birthweights, gestational ages, severity of birth asphyxia, and severity of hyaline membrane disease (HMD). IVH followed severe HMD and was associated with cessation of the babies' own respiratory efforts while on a ventilator and also with characteristic cardiorespiratory events. The minimum arterial pressure before IVH was lower than in comparable babies who survived. It is suggested that fluctuations of systemic blood pressure from initial low levels may be important in the pathogenesis of IVH. It is possible that changes in cerebral blood flow are of even greater significance.

Asphyxia Neonatorum↗
PubMed1978

Peripheral pulmonary artery stenosis.

A term infant, born by caesarean section for fetal distress, developed grunting and cyanosis by 15 minutes of age. Ventilation at low pressures was achieved without difficulty but did not improve blood gas levels, and he died at 26 hours. Necropsy examination showed large heart and small lungs; histologically the lungs showed multiple obstructive lesions at medium size pulmonary artery level.

Constriction, Pathologic↗
PubMed1977

Paediatric preparation for multiple premature births.

We describe the managment of 2 sets of pre-term quadruplets born to 2 women pregnant concurrently following the induction of ovulation with gonadotrophin. Careful antenatal planning was necessary to provide for each of the 8 pre-term infants a standard of neonatal medical and nursing care comparable to that normally available for singleton pre-term infants.

Adult↗
PubMed1977

Effect of blood transfusion in low birthweight infants.

143 fresh blood transfusions were given to 32 low birthweight babies, 28 of whom had hyaline membrane disease. The arterial or central venous pressure was raised by a blood transfusion if before transfusion the mean arterial pressure was less than 35 mmHg or if the diastolic central venous pressure was less than -- 0-5 mmHg. There was no effect of blood transfusion on pH. It therefore appears either that metabolic acidosis in hyaline membrane disease is not caused by poor peripheral perfusion or that blood transfusion does not increase peripheral blood flow in this condition. The safety of the procedure is assessed.

Blood↗
PubMed1975

Bottle-feeding: influence of teat-hole on suck volume.

Infants have been fed with teats whose end-holes varied in shape and size. Two types of feeding-bottles were used. With conventional feeding-bottles, variations of teat-hole shape and size did not significantly alter the volumes of milk obtained at each suck. However, when an infant feeding-bottle was used which contained a valve, then variations in teat-hole shape and size did alter the volumes of milk obtained. The volume of milk obtained from a standard teat under such circumstances was the same as the volume previously calculated for breast-feeding.

Animals↗
PubMed1975

Breathing and sucking during feeding in the newborn.

Eighteen normal full-time infants aged from 1-10 days were fed both normal saline and distilled water from a conventional feeding bottle. Fifty-four sets of observations were made when 44 infants were fed both cow's milk (Half Cream Cow & Gate) and expressed human milk. During feeding, measurements were made of breathing, sucking, and the flow of milk from a feeding bottle which incorporated an electromagnetic flowmeter transducer. Integration of the flow of milk measured the volume of milk swallowed by the baby. The results suggest that the patterns of feeding and breathing differ in some infants when different fluids are given to them.

Age Factors↗
PubMedDate not supplied

Surveillance of poliomyelitis in the United Kingdom.

Routine surveillance of poliomyelitis is undertaken through statutory notification, laboratory reporting, and examination of death certificates where poliomyelitis is mentioned. All health districts report weekly and include zero reporting of poliomyelitis in their returns. UK weekly reports on poliomyelitis are forwarded to WHO Europe. There have been no wild virus cases for over a decade. Since August 1991, there has been active surveillance of acute flaccid paralysis (AFP) in children under 16 years. All Consultant Paediatricians are contacted monthly through the British Paediatric Surveillance Unit and asked for reports of any cases of AFP. These are then investigated further. The study protocol specifies the investigations that are required for AFP cases, including stool samples for virology. AFP rates from this surveillance, approximately one per hundred thousand children under 16 years, provide a valuable guide for industrialised countries; consideration is being given to extending this scheme into the adult population. In 1992, a 44-year-old man died after sudden onset of AFP. Histology suggested poliomyelitis, and intensive investigations were undertaken to establish a diagnosis. The role of AFP surveillance and investigation of suspected cases are discussed in the light of the need to establish that poliomyelitis has been eliminated.

Adolescent↗