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Biomedical subjects

D M Morens

Publications and source records attributed to D M Morens.

At least 73 records · Page 4Linked to original sources
PubMed1981

Surveillance of Reye syndrome in the United States, 1977.

Between December 1, 1976, and November 30, 1977, 454 cases of Reye syndrome were reported to the Centers for Disease Control by 43 states. Analysis of data about these cases revealed that Reye syndrome primarily affected white children under age 18 years, with a mean age of 7.7 years and bimodal incidence peaks in infancy and at age 6-7 years, was temporally and geographically associated with influenza B for about 75% of cases, but also occurred sporadically and not in association with influenza B activity. Although Reye syndrome was reported infrequently for non-white children aged one year or older, there was a high incidence in minority infants, and the case-fatality ratio in infants of all races was significantly higher than that of the older children. Favorable outcome was associated with prolonged interval between onset of prodromal illness and hospitalization, admission to hospital at a milder stage of illness, and treatment in hospitals with established pediatric training programs.

Adolescent↗
PubMed1980

Kawasaki disease in healthy young adult.

This report describes a 26-year-old woman who fulfills the criteria for the diagnosis of Kawasaki disease or mucocutaneous lymph node syndrome, an acute febrile illness that usually afflicts young children. The diagnosis is made in persons with fever lasting 5 or more days when four of the following criteria are met: bilateral injection of ocular conjunctivae; the involvement of the mucous membranes of the upper respiratory tract consisting of any combination of the following--redness and fissuring of lips; "strawberry tongue," or erythema of the pharynx; involvement of the peripheral extremities characterized in the early stages by an indurative erythematous rash of palms and soles followed by membranous desquamation; polymorphous nonvesicular truncal exanthem; and acute nonsuppurative enlargement of cervical lymph nodes. An added stipulation is that the illness must not be attributable to a known disease process.

Adult↗
PubMed1980

An outbreak of varicella-zoster virus infection among cancer patients.

An outbreak of varicella-zoster infection occurred among patients of the Medicine Branch, National Cancer Institute, National Institutes of Health. Epidemiologic investigation suggested that the outbreak was due to two distinct types of disease. One type was acquired without previous exposure to other diseased patients and invariably associated with dermatomal lesions. The other, an a typical form, was associated with person-to-person transmission and equivocal initial dermatomal distribution and had an incubation period of approximately 11 to 25 days. Despite the diagnosis of zoster, the latter probably was varicella, occurring in patients who were immunodeficient because of disease, debility, and chemotherapy.

Adult↗
PubMed1980

National surveillance of Kawasaki disease.

Information about 261 cases of Kawasaki disease (KD) was reported to the Center for Disease Control (CDC) between July 1976 and July 1978. KD occurred at all times of the year in young, previously healthy children throughout the United States. KD was more common in infants and toddlers, males, and Asian and part-Asian children. The illness was characterized by acute onset of prolonged high fever; maculopapular or scarlatiniform rash; adenopathy; injection of the conjunctival and mucous membranes of the upper respiratory tract; redness of the palms and soles; indurative edema of the extremities; desquamation, arthralgias; and elevated white blood cell count, erythrocyte sedimentation rate, and platelet count. Complications included gallbladder disease and carditis; 2.8% died. Surviving patients were hospitalized for a mean of 8.9 days.

Age Factors↗
PubMed1979

A waterborne outbreak of gastroenteritis with secondary person-to-person spread. Association with a viral agent.

In December, 1976, an outbreak of gastroenteritis occurred at a resort camp in Colorado. Data obtained by questionnaire from 760 persons indicated that 418 (55%) had had gastroenteritis at the camp or within a week of leaving it, with peak onset within a two-day period. Symptoms included vomiting (81%), diarrhoea (65%), and fever (49%); median duration of illness was twenty-four hours. The attack-rate increased with consumption of water or ice-containing beverages. The camp water supply was found to be inadequately chlorinated and contaminated by a leaking septic tank. Although routine laboratory tests did not reveal bacterial, viral, or parasitic pathogens, immune electron microscopy detected virus-like particles in two of five diarrhoeal stool filtrates. Oral administration of one of these bacteria-free filtrates to two volunteers induced a gastrointestinal illness similar to that observed in the camp visitors.

Camping↗
PubMed1979

WBC count and differential. Value in predicting bacterial diseases in children.

To assess published criteria for distinguishing between bacterial and non-bacterial infections by examination of the WBC count and differential, we reviewed 328 consecutive inpatient admissions to a pediatric communicable diseases service. In our experience, the WBC count and differential could not differentiate between bacterial and nonbacterial disease.

Bacterial Infections↗
PubMed1979

Non-polio enterovirus disease in the United States, 1971--1975.

Reports to the Center for Disease Control on isolation of non-polio enteroviruses for the years 1971--1975 were analysed. During the 5 year period, enterovirus isolations were reported from 7 075 individuals. 90% of these occurred in the 7 month interval of May--November. Enteroviruses were isolated more frequently from males than females for all age groups in all 5 years. The incidence of reported isolations decreased with increasing age, and an inverse relationship between severity of disease and age was suggested. Clinical diagnoses associated with enteroviral isolations included aseptic meningitis, encephalitis, upper respiratory tract disease, non-specific febrile illness, gastroenteritis, pneumonia and lower respiratory tract disease, exanthem, and enanthem.

Age Factors↗
PubMed1979

Congenital tuberculosis and associated hypoadrenocorticism.

Two cases of probable congenital tuberculosis occurring in the ten-year period from 1966 to 1976 are reported. One infant with confirmed congenital tuberculosis also had symptomatic hypoadrenocorticism. Tuberculosis should be considered in the differential diagnosis of the seriously ill infant.

Addison Disease↗
PubMed1979

Reye syndrome associated with vaccination with live virus vaccines. An exploration of possible etiologic relationships.

To determine whether vaccination with live virus vaccines may be etiologically related to Reye syndrome, we examined 404 cases reported to the Center for Disease Control. Fifteen of 269 children with Reye syndrome has been inoculated with live virus vaccines within 30 days before onset of illness. Although this temporal relationship may have occurred by chance, seasonal distribution and clustering of incubation periods suggests that live virus vaccines may occasionally serve as cofactors in the etiology of Reye syndrome through undefined mechanisms.

Adolescent↗
PubMed1979

Epidemic dengue fever in Puerto Rico, 1977: a cost analysis.

During the period July-December 1977, a widespread epidemic of dengue fever occurred in Puerto Rico. The cost of the epidemic was calculated, using upper and lower limit incidence figures, in terms of direct costs (medical care and epidemic control measures) and indirect costs (lost production of ill workers and parents of ill children). Direct costs were estimated to range between $2.4 and $4.7 million. Indirect costs were calculated by using current (1977) employment and wage data and population extrapolations from the 1970 census, and entailed a loss to the Puerto Rico economy of from $3.7 to $10.9 million. The total cost of this epidemic, therefore, was estimated to be in a range of $6.0 to $15.6 million, of which epidemic control measures comprised 7.8--20.2%.

Adolescent↗
PubMed1978

Enteroviral disease in early infancy.

To discover the nature of enteroviral infections in early infancy (infants less than two months of age) in the United States, data were examined of 338 such infants with nonpolio enterovirus isolates reported to the Center for Disease Control in 1972-1975. Interpretation of such data is limited by reporting bias and difficulty in documenting disease causality. Enteroviral disease was severe in 74% of the infants. The most common clinical manifestations were meningitis, severe systemic disease, nonspecific febrile illness, and gastrointestinal symptoms. Fifty-one percent of all enteroviral disease was associated with echoviruses; 45% with Coxsackie B viruses; and only 4% with Coxsackie A viruses. Disease was more prevalent in the summer months, was recognized throughout the country, and occurred more frequently in males.

Coxsackievirus Infections↗