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Biomedical subjects

D M Mills

Publications and source records attributed to D M Mills.

48 records · Page 3Linked to original sources
PubMed1980

Heightened lung bactericidal activity in mice after aerosol immunization with Re 595 Salmonella minnesota: importance of cellular rather than humoral factors.

Intrapulmonary bactericidal activity was enhanced against aerosolized Serratia marcescens, Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus two weeks after aerosol immunization with Re 595 Salmonella minnesota. To define better this nonspecific stimulation of antibacterial lung defenses, mice were simultaneously challenged with S. aureus and S. marcescens up to 30 days after aerosol immunization with Re. Enhanced bactericidal activity against both organisms was noted, although activity against Serratia was more pronounced during the first week after immunization. Repetitive aerosol immunization with Re also resulted in enhanced bactericidal activity. Macrophages harvested from mice after aerosol immunization were "activated" by ultrastructural criteria and had enhanced intracellular bactericidal activity against S. aureus. Aerosol immunization also caused an increase in polymorphonuclear leukocytes in lung lavage fluid, which may have been important in activity against Serratia. Mice systemically immunized with Re developed high antibody titers in serum and lung washings but had no stimulation of lung antibacterial activity.

Aerosols↗
PubMed1976

Hypertrophic osteoarthropathy in adults with cystic fibrosis.

Three adult patients with cystic fibrosis presented with arthralgia, and investigation for the usual causes of arthritis proved negative. Radiographs of long bones revealed periostitis and new bone fromation characteristic of hypertrophic osteoarthropathy. Symptomatic improvement occurred after analgesic and anti-inflammatory therapy. In patients with cystic fibrosis and bone or joint pain, the diagnosis of hypertrophic osteoarthropathy should be considered and long bone radiographs obtained.

Adult↗
PubMed1976

Polymorphonuclear leukocyte inclusions and impaired bacterial killing in patients with Felty's syndrome.

Humoral factors, phagocytosis, bactericidal capability, and ultrastructural morphology of blood polymorphonuclear leukocytes were investigated in 10 patients with Felty's syndrome. Five patients had suffered significant bacterial infections in the past two years while five other patients had not had bacterial infections. The patients with infections had higher concentrations of serum cryoglobulins, and their neutrophils contained immunoglobulin inclusions as seen by immunofluorescent and electron microscopy. Additionally, leukocytes from these patients showed decreased ability to kill Staphylococcus aureus and a minor defect in phagocytosis. There was a generalized subcellular disorganization of these inclusion containing neutrophils and a slower than normal release of lysosomes. Several of the above abnormalities may contribute to an increased susceptibility to bacterial infections in patients with Felty's syndrome.

Adult↗
PubMed1975

HL-A antigens and sacroiliitis.

The histocompatibility antigen W27 has been found to have a high incidence in ankylosing spondylitis (96%), Reiter syndrome (74%), and other forms of arthritis that may involve the axial skeleton. In patients with Reiter syndrome, there was no correlation between the presence of W27 antigen and the extent or duration of the symptoms. Sacroiliitis was predominantly found in those patients with W27 antigen in all the axial arthropathies. Tissue-typing techniques may be of value in detecting early or atypical disease.

Arthritis, Reactive↗
PubMed1975

Cyclophosphamide therapy for rheumatoid arthritis.

Cyclophosphamide in high doses was given for six months to 19 patients with rheumatoid arthritis. A second group of patients with rheumatoid arthritis whose conditions were stable on low-dose prednisone received in addition either cyclophosphamide or placebo for six months. Measurements of joint function and joint inflammation were used to estimate disease activity. Joint inflammation progressively decreased and joint function improved in the high-dose group. The low-dose cyclophosphamide-plus-prednisone group had a similar response that was different from the prednisone-plus-placebo group. Cyclophosphamide toxicity was common in the high-dose group and minimal in the low-dose-plus-prednisone group. Cyclophosphamide therapy improved the arthritis of these patients. The results were almost as good in the low-dose-plus-prednisone group, and the toxicity was much less.

Administration, Oral↗
PubMed1975

Inhibition of leukocyte candidacidal activity by serum from patients with disseminated candidiasis.

The effect of normal serum and serum for seven patients with disseminated candidiasis (DC) on candidacidal activity of normal human neutrophils (PMNL) was studied. PMNL incubated in DC serum had depressed candiacidal activity when compared to studies with normal serum. The candidacidal defect was not related to differences in particle uptake since phagocytic indices were similar with either normal or DC serum. DC serum did not affect PMNL bactericidal activity against Staphylococcus aureus. When Candida albicans (CA) was incubated in either normal or DC sera, washed, and added to PMNL in normal serum, pronounced inhibition of candidacidal activity was seen in all studies with CA previously incubated in DC serum. Dilution of DC serum or absorption of DC serum with heat-killed CA reversed the candidacidal defect. Ultrastructural studies of phagocytized CA demonstrated small ("tight") phagolysosomes and a delay in breakdown of an electron-dense coating on CA previously incubated in DC serum when compared to controls. Inhibition of leukocyte candidacidal activity appeared to be related to high titers of IgG antibodies against CA present in DC serum.

Antibodies, Fungal↗
PubMedDate not supplied

Esophageal varices in Felty's syndrome: A case report and review of the literature.

A case of upper gastrointestinal tract hemorrhage secondary to esophageal varices in a patient with Felty's syndrome prompted a review of the pathogenesis and treatment of this condition. Six previously reported cases of this association were found. The clinical picture is that of long-standing rheumatoid arthritis with severe articular and extraarticular manifestations including splenomegaly, depression of the blood elements, mild liver function abnormalities, portal hypertension without cirrhosis or portal vein obstruction, an elevated splenic blood flow, and a reduction in portal hypertension by simple splenectomy. The presence of portal hypertension with varices may be another indication of splenectomy in patients with Felty's syndrome.

Aged↗
PubMedDate not supplied

Still's disease in an adult: A link between juvenile and adult rheumatoid arthritis.

A 52-year-old man developed rheumatoid factor negative, chronic, symmetrical polyarthritis associated with high intermittent fever and morbilliform evanescent rash at the onset. A detailed investigation and follow-up for two years failed to reveal any secondary cause. The onset and course resemble Still's disease in children. The synovial membrane histology and electron microscopy were consistent with early rheumatoid arthritis. Adult onset Still's disease reported in the literature is reviewed and compared with Still's disease in children.

Age Factors↗