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Biomedical subjects

D M Laskin

Publications and source records attributed to D M Laskin.

At least 73 records · Page 4Linked to original sources
PubMed1997

Changes in patient screening for a clinical study of dental implants after increased awareness of tobacco use as a risk factor.

Independent external monitoring committees are an important part of scientific clinical trials. They monitor patient safety, study progress, investigators' performance, and accurate interpretation/reporting of the study data. Data trends observed by a study monitoring committee detected a change in the pattern of patient screening by investigators after an increased awareness that tobacco use could directly compromise the osseointegration of root-form dental implants. This increased awareness is believed to have altered the number of active smokers accepted into a multicenter prospective dental implant study. Recent data analyses indicate that the success ratios were improved by alterations in this discretionary inclusion-exclusion criterion.

Data Interpretation, Statistical↗
PubMed1997

Pseudocysts of the mandibular condyle in children.

The authors evaluated the panoramic radiographs of 1,193 consecutively treated patients 18 years old and younger for the presence of asymptomatic radiolucencies in the mandibular condyles. The 27 radiographs initially selected were examined by four independent reviewers. Of the 1,193 patients, 18 (1.5 percent [10 female and eight male]) met the criteria for condylar pseudocysts. Follow-up radiographs showed minimal or no change in size of the radiolucencies. Clinicians need to be aware of these anatomic variations so that patients are not subjected to inappropriate treatment.

Adolescent↗
PubMed1996

The effect of L-dopa on the healing of a rat mandibular defect.

PURPOSE: This study was designed to evaluate the effect of L-dopa on healing of a surgically created bony defect in the adult male rat. MATERIALS AND METHODS: Thirty-six animals underwent surgery to create a 4-mm circular defect in the left mandibular angle. They were then randomly divided into two equal groups, one receiving 0.2 g/kg/day of L-dopa for 10 days by orogastric gavage, the other group acting as a control. Six experimental and six control animals were killed at 2 weeks, and five experimental and six control animals were killed at 4 and 6 weeks postoperation. Healing was classified as complete, partial, or incomplete based on gross and radiographic observations. RESULTS: Gross observation of the experimental mandibles showed five completely healed defects (31.25%), five partially healed defects (31.25%), and six defects with no healing (37.5%). Control mandibles showed three defects with partial healing (16.67%) and 15 with no healing (83.33%). Radiographs were taken of randomly chosen mandibles in each control and experimental group. Of the six experimental mandibles, one showed no healing, three showed partial healing, and two showed complete healing of the defect. The six control mandibles showed three defects with no bone formation and three with partial healing. CONCLUSIONS: The data from this study indicate that L-dopa had a promoting effect on the bony healing of defects in the rat mandible.

Administration, Oral↗