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Biomedical subjects

D M Lang

Publications and source records attributed to D M Lang.

51 records · Page 3Linked to original sources
PubMed1987

Distribution of methacholine inhalation challenge responses in a selected adult population.

To determine bronchial reactivity patterns in adults, 211 subjects, 22 to 86 years of age, underwent a methacholine challenge in a Natural History of Asthma study. The diagnosis of asthma or nonasthmatic allergic diseases was based on a standardized respiratory questionnaire. Subjects were nonsmokers and had not had an infection for 1 month. Intradermal skin tests were done to a battery of common antigens. The methacholine challenge response was expressed as the area under the dose-response curve integrated to a 35% fall in the FEV1 or 800 breath units. Thirty-three subjects with asthma, 47 normal subjects from normal families (NF), 59 normal subjects from families with asthma (AF), 31 allergic subjects without asthma, 23 subjects with questionable asthma, and 18 subjects with prior asthma were studied. Overall, 50% of the subjects without asthma had a negative response to methacholine. There was a difference (p less than 0.02) in the distribution of log10 methacholine area under the dose-response curve integrated to a 35% fall in the FEV1 or 800 breath units responses in normal subjects from NFs compared to normal subjects from AFs. The allergic subjects from AF had a greater degree of bronchial reactivity compared to normal individuals from NF. The age of the normal subjects had an influence on the degree of bronchial reactivity. Methacholine challenge studies in adult patients need to be interpreted with age and family history in mind.

Administration, Inhalation↗
PubMedDate not supplied

The use of the Ma-Griffith technique for percutaneous repair of fresh ruptured tendo Achillis.

All patients treated for a rupture of the Achilles tendon by the technique of percutaneous repair were identified from a five year period up to 1987. A review of the patients and results of this technique was undertaken using a clinical grading system. Review was conducted between 18 and 81 months following the injury. Of 38 patients followed up, 71% achieved good results and only 8% poor results. The re-rupture rate for this series was 8%. Sural nerve involvement (13%) was found to be a troublesome complication. During the period under study, a modification to the technique was introduced which abolished this complication. We present our results and describe the modification to the technique. The importance of the use of nonabsorbable sutures is emphasized.

Achilles Tendon↗