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Biomedical subjects

D M Lane

Publications and source records attributed to D M Lane.

At least 55 records · Page 3Linked to original sources

Locus and persistence of capacity limitations in visual information processing.

Although there is considerable evidence that stimuli such as digits and letters are extensively processed in parallel and without capacity limitations, recent data suggest that only the features of stimuli are processed in parallel. In an attempt to reconcile this discrepancy, we used the simultaneous/successive detection paradigm with stimuli from experiments indicating parallel processing and with stimuli from experiments indicating that only features can be processed in parallel. In Experiment 1, large differences between simultaneous and successive presentations were obtained with an R target among P and Q distractors and among P and B distractors, but not with digit targets among letter distractors. As predicted by the feature integration theory of attention, false-alarm rates in the simultaneous condition were much higher than in the successive condition with the R/PQ stimuli. In Experiment 2, the possibility that attention is required for any difficult discrimination was ruled out as an explanation of the discrepancy between the digit/letter results and the R/PQ and R/PB results. Experiment 3A replicated the R/PQ and R/PB results of Experiment 1, and Experiment 3B extended these findings to a new set of stimuli. In Experiment 4, we found that large amounts of consistent practice did not generally eliminate capacity limitations. From this series of experiments we strongly conclude that the notion of capacity-free letter perception has limited generality.

Adult↗

Changes in the serum lipids and apolipoproteins in the first four weeks of life.

The neonatal serum lipid transport system was monitored in the 1st month of life to determine the impact of oral feeding (breast versus formula). Lipid and apolipoprotein levels were measured in the serum of normal newborn infants collected at birth, 3, 14, and 28 days of age. Fatty acid and neutral lipid studies were determined by gas-liquid chromatography and apolipoprotein levels were done by electroimmunoassay. Following collection of data, the results were divided into two groups corresponding to breast-fed (BF) or formula-fed (FF) infants. Only triacylglycerols at 3 days of age were significantly higher (p less than 0.04) in FF infant serum when compared to BF levels. Unesterified cholesterol levels in both groups were similar at all intervals, the cholesterol esters were higher at 14 and 28 days in BF infants. ApoA-I and ApoB levels were higher at 3 days in FF, but ApoC-III levels were the same. At all other sampling times, no discernible differences in these parameters were found between BF and FF. For the infants as a group, changes in levels with increasing age were similar for both ApoA-I and cholesterol esters, as was the case for ApoB and triacylglycerols. However, numerous differences between BF and FF were seen in molecular forms of triacylglycerols and cholesterol esters, reflecting the dietary fatty acid differences between breast milk and formula. Analyses of the fatty acid content of these two diets demonstrated that human breast milk contained twice as much palmitic and oleic acid but only one-half the linoleic acid of formula.(ABSTRACT TRUNCATED AT 250 WORDS)

Age Factors↗

Ibotenic acid lesions of the lateral hypothalamus: comparison with 6-hydroxydopamine-induced sensorimotor deficits.

Three groups of rats received unilateral injections of ibotenic acid, 6-hydroxydopamine or vehicle control into the lateral hypothalamic area, and were given a range of tests of sensorimotor capacity. As expected from previous reports, the 6-hydroxydopamine injections induced a marked sensorimotor impairment to the contralateral side of the body. By contrast, the ibotenic acid injections produced no detectable sensorimotor changes, although the parameters and histological extent of the lesion were identical to those which produce aphagia, adipsia and sustained regulatory impairments when administered bilaterally. These results dissociate the classic electrolytic lesion of the lateral hypothalamus into homeostatic impairments following damage to intrinsic hypothalamic neurones, and sensorimotor impairments dependent only on damage to passing catecholamine fibre systems.

Animals↗

Factors affecting the lipid and apolipoprotein levels of cord sera.

In studying the human lipid transport system as it changes from the fetal to the adult form, data were collected on cord sera levels of lipids and apolipoproteins (A-I, A-II, ApoB, C-I, C-II, C-III, ApoD, and ApoE) from infants whose lipid metabolism might have been modified by a variety of factors present before, at, or after delivery. The results clearly indicated that many factors affect the levels of both lipids and apolipoproteins at birth. Method of delivery had little effect except in relation to either fetal immaturity (increased total cholesterol) or fetal stress (increased triglycerides). Birth weight was related to changes in free cholesterol, C-I, C-III, and ApoE levels. Gestational age had greater impact upon both serum lipids and apolipoproteins. With increasing fetal maturity, total cholesterol, free cholesterol, A-II, C-II, and ApoE progressively fell whereas triglyceride and ApoD rose. A variety of clinical disorders were also associated with changes in serum lipid and apolipoproteins. Anencephaly produced marked increases in both free and total cholesterol as well as most apolipoproteins. Significant reductions in triglyceride and ApoD levels were found in infants who subsequently became ill in the postnatal period with problems relating to carbohydrate metabolism (e.g., infants of diabetic mothers). Infants with respiratory distress were found to have decreased levels of total cholesterol and ApoB, both of which are increased in prematurity, a condition with which respiratory distress (RD) is usually associated. The changes in cord sera lipid and apolipoprotein levels found in a variety of clinical situations may provide new diagnostic approaches to postnatal problems arising in the newborn.

Abnormalities, Multiple↗

Attending to spatial locations: a developmental study.

In 2 experiments, 7- and 8-year-old children and college students performed a letter-detection task in which reaction time was the dependent variable. Expectancy was manipulated by varying the probability the stimulus would appear at the center of an imaginary circle rather than along the perimeter. Although both age groups responded consistently faster to stimuli presented in expected locations than to stimuli presented in unexpected locations, this expectancy effect was larger for the children than it was for the college students. In a third experiment, these results were replicated using a luminance-detection task with 5-year-olds, 8-year-olds, and college students as subjects. It was concluded that children as well as adults are able to expand or contract the breadth of their attentional focus in accordance with task demands and that there is a developmental change in the efficiency with which a stimulus presented in an otherwise empty field can be located. Furthermore, it was suggested that children may be more disrupted by the occurrence of an unexpected event than adults are.

Attention↗

Studies on the apolipoproteins and lipoproteins of cord serum.

Studies on the cord serum lipid transport system were initiated to determine whether there is a correlation between decreased cord serum lipid levels and the absence or diminished level of some or all of the human serum apolipoproteins. Immunologic studies indicated the presence of all the well-characterized apolipoproteins and provided evidence that these apolipoproteins occurred primarily as distinct lipoprotein species with a paucity of association complexes or what others have termed "triglyceride-rich" lipoproteins. Quantitation of the apolipoproteins present in cord serum by electroimmunoassay yielded the following mean levels: A-I = 73O mg/liter; A-II = 410 mg/liter; apolipoprotein B = 280 mg/liter; C-I = 59 mg/liter; C-II = 32 mg/liter; C-III = 65 mg/liter; apolipoprotein D = 37 mg/liter; and apolipoprotein E = 85 mg/liter. Levels of C-I, C-II, and apolipoprotein E approached adult levels (83 to 86% of the adult levels), whereas apolipoproteins B and D were most reduced when compared to the adult concentrations, 29 and 37%, respectively. The three other apolipoproteins were present at approximately one-half the levels found in adults.

Adult↗

Effects of continuous or discontinuous maintenance therapy on subsequent remission maintenance in childhood leukemia.

This study was designed to determine if resistance to a standard drug during the second remission of children with acute leukemia was reduced by discontinuation of therapy during the initial remission. The initial maintenance therapy was either 6-mercaptopurine (6-MP), methotrexate (MTX), or cyclophosphamide (CYC) given continuously to relapse or discontinued (at random) at 2 or 6 months. Following the initial relapse and after induction of a second complete remission, 72 evaluable patients received (continuously to relapse) either 6-MP (53 patients) or CYC (19 patients) for the second remission maintenance. Resistance of 6-MP occurred during the second maintenance, regardless of the drug used during the initial maintenance, in that the length of second remissions was significantly shorter than the length of first remissions. However, this resistance was most pronounced in patients who initially relapsed while on continuous 6-MP maintenance (medium duration of remission [MDR] of 9 weeks). Patients whose initial relapse occurred after the discontinuation of 6-MP had a MDR of 23 weeks and patients whose second remission was maintained with CYC (after relapse from initial continuous remission on 6-MP) had a MDR of 25 weeks.

Acute Disease↗

Interrupted vs. continued maintenance therapy in childhood acute leukemia.

A total of 313 patients with childhood acute leukemia received a combination of vincristine (2 mg/m2/week) and prednisone (60 mg/m2/day); 86% of 276 evaluable patients achieved a complete bone marrow remission in a median of 35 days. When a complete bone marrow remission was achieved, patients were randomized to one of three oral maintenance therapies: 6-mercaptopurine (6MP) (75 mg/m2/day), methotrexate (MTX) (25 mg/m2/twice weekly), or cyclophosphamide (CYC) (100 mg/m2/day). Patients receiving maintenance therapy were further randomized at 2 and 6 months after the start of maintenance either to continue or discontinue therapy. tthe median lengths of subsequent bone marrow remission for patients randomized at 2 months to continue vs. discontinue therapy were: 37 vs. 19 weeks for 6-MP patients; 25 vs. 14 weeks for MTX patients; and 29 vs. 13 weeks for CYC patients. The median lengths of subsequent marrow remissions for patients receiving maintenance therapy for 6 months and randomized to continue vs. discontinue were: 57 vs. 17 weeks for 6-MP patients; 60 vs. 40 weeks for MTX patients; and 23 vs. 10 weeks for CYC patients. Results indicate a significant advantage for continuing maintenance therapy at 2 and 6 months after the start of complete bone marrow remission.

Acute Disease↗

Long-term results of reinforcement therapy in children with acute leukemia.

A total of 180 children with acute leukemia was randomized to one of two induction regimens: vincristine plus prednisone, or 6-mercaptopurine plus prednisone. Of 170 patients evaluable for induction therapy, a hematologic remission was achieved in 83% (72/87) on vincristine plus prednisone, and in 93% (77/83) on 6-mercaptopurine plus prednisone. When hematologic remission was achieved, patients were randomized to one of three maintenance schedules: 6-mercaptopurine alone, 6-mercaptopurine plus prednisone for 4 weeks every 3 months, or 6-mercaptopurine plus prednisone plus vincristine for 4 weeks every 3 months. The durations of hematologic remission were compared from the achievement of hematologic remission to bone marrow relapse. The survival data were presented as an overview of the effect of this initial therapy on duration of survival. There was no statistical difference between the two induction regimens. The most important finding in the comparison of the three maintenance schedules was that reinforcement of 6-mercaptopurine maintenance therapy with either prednisone or prednisone plus vincristine resulted in significantly longer durations of remission. Vincristine added to prednisone for reinforcement after induction of remission by vincristine plus prednisone did not increase the duration of hematologic remission or survival over prednisone reinforcement alone.

Acute Disease↗