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Biomedical subjects

D M Jenkins

Publications and source records attributed to D M Jenkins.

At least 55 records · Page 3Linked to original sources
PubMed1978

Production of fibrinolytic enzymes by macrophages on intrauterine contraceptive devices.

Intrauterine contraceptive devices (IUCDs) were removed from 44 patients with a variety of clinical conditions, and incubated in culture media. Following incubation for up to 96 hours the total numbers of macrophages on each device were counted. The Lippes loop and Saf-T- Coil had higher counts than the Copper 7. The counts on all devices were higher at mid-cycle and during menstruation and significantly higher in patients with menorrhagia and intermenstrual bleeding (P less than 0.0005). Samples of culture media were taken on a number of occasions for up to 96 hours for fibrinolytic studies, and fibrinolytic activity increased with time in 10 of 16 cases where fibrinolytic activity was detected. There was a weak positive correlation between the number of cells on each of the 10 devices which produced a rise in fibrinolytic activity and the highest level of activity produced by each of the devices (r = +0.59; P less than 0.05). Plasminogen activator activity was maximum early in the incubation period, while plasmin-like activity predominated in later samples. The possible role of macrophages in IUCDs in causing menorrhagia is discussed.

Cell Count↗
PubMed1977

T- and B-lymphocyte subpopulations in pre-invasive and invasive carcinoma of the cervix.

Lymphocyte subpopulations in patients with pre-invasive and invasive cervical carcinoma, other gynaecological malignancies and controls were studied. T lymphocytes were recognized by their ability to form spontaneous rosettes with sheep red blood cells (E rosettes). Two surface marker characteristics were used to detect B lymphocytes: the receptors for activated complement responsible for erythrocyte-antibody-complement (EAC) rosette formation, and surface membrane immunoglobulin (SMIg), which is readily stainable by immunofluorescence. There was a significant depression in T cells in association with invasive but not pre-invasive cervical carcinoma. The results for B cells varied according to the method used for their detection. EAC rosette-forming (EAC-RFC) were significantly raised in patients with invasive cancers but not in patients with pre-invasive cancer. SMIg-bearing cells were not significantly altered by the presence of malignant disease. The changes in E-RFC and EAC-RFC numbers were more marked in patients with extensive cancers. Possible functional implications of these findings are discussed.

Adolescent↗
PubMed1977

Immunological aspects of the pathogenesis of pregnancy hypertension.

Changes involving the immune system may be instigators of, or consequent upon, disorders in other systems in the natural history of gestosis. The extent of the immune 'disorder' may not correlate with the severity of the disease as manifest in either eclampsia or fetal death. A number of variables, e.g. hormonal and genetic, could affect any immunological trigger mechanism or any secondary altered immune response. Thus attempts to find an immunological factor in gestosis that operates in all cases may prove unrewarding. Certain matings, immunogenetic constitutions, or certain feto-maternal immune relationships may predispose to a particular pathology and directly or indirectly potentiate other pathological processes. Others may either have no effect or conceivably have even a homeostatic effect protecting the maternal host from pathological change. The picture of the role of immunological factors in the pathogenesis of pregnancy hypertension is no more, as yet, than a few hesitant, unrelated lines. However, the lines are getting more numerous and stronger.

ABO Blood-Group System↗
PubMed1977

Deficienty of specific HLA antibodies in severe pregnancy pre-eclampsia/eclampsia.

The paradox of the survival of the foetal allograft remains unresolved as does the aetiology of pre-eclampsia/eclampsia--the principle disease of pregnancy. In a prospective study of very severe cases of pre-eclampsia we have found significantly reduced antibody to paternal histocompatibility antigens. Lowered immune response to the foetal allograft may play a role in severe cases of pre-eclampsia.

Antibody Formation↗
PubMed1976

Patterns of antenatal care, perinatal mortality, and birth-weight in three consultant obstetric units.

Patterns of antenatal care in three selected consultant units in Britain have been analysed. The study shows that antenatal care operates differently in the three hospitals. Pregnancies resulting in perinatal deaths may not always receive appropriate obstetric care. Patients appear to be at an advantage if they receive consultant-unit care at some stage of their pregnancy.

Ambulatory Care↗
PubMed1976

The response of lymphocytes to phytohaemagglutinin in women with pre-eclampsia.

The response of maternal lymphocytes to phytohaemagglutinin was determined during and after pregnancy in patients with severe pre-eclampsia and in controls. The patients with pre-eclampsia showed a greater degree of immunosuppression during pregnancy than the normotensive controls. This was apparent in the presence and absence of maternal serum. In pre-eclampsia there may be an abnormality affecting the T cell subpopulation of lymphocytes and also a decreased immunosuppressive effect of maternal serum.

Female↗
PubMed1976

Chorionic haemangiomata and abruptio placentae. Case report and review.

A case of fetal death from abruptio placentae is reported in which the placenta was the seat of multiple chorangiomata. This association is believed not to have been fortuitous and a possible mechanism is suggested by which chorangioma may contribute to the pathogenesis of placental abruption. The incidence, morphological variation and clinical manifestations of placental chorangiomata are briefly discussed.

Abruptio Placentae↗
PubMed1976

Immunogenetic factors in aetiology of pre-eclampsia/eclampsia (gestosis).

The evidence that genetic and immunogenetic influences operate in the causation of pre-eclampsia/eclampsia (gestosis) is reviewed. The problems of definitive diagnosis are discussed along with the possibility of a multifactorial aetiology. The difficulties of differentiating trigger and effector mechanisms are also considered. It is concluded that there is evidence for a predisposition, probably genetic, operating in some cases, an immunogenetic mechanism in others, and chromosomal factors in a small group.

Aneuploidy↗
PubMed1975

Histories obtained by two-stage questionnaire with automated transcript in specialist gynaecological practice.

A two-stage questionnaire which the patient completes at home has been developed for use by gynaecological outpatients. The first stage (root) identifies the patient's problem and obtains general background information. The second stage (branch) deals with the presenting problem in depth. The system has proved highly acceptable to patients. At the clinic a non-medical assistant uses a programmed typewriter to transcribe the data into a typewritten history which is handed to the doctor before he examines the patient. The transcript compares favourably with the conventional hand-written history in content, ease of assimilation, and cost. While the questionnaire itself is an excellent means of collecting information it becomes an efficient means of transmitting information to the clinician only when combined with the transcript facility. There is no storage of confidential information and no scope for unethical disclosure.

Adolescent↗
PubMed1975

Maternal cardiomyopathy of pregnancy causing stillbirth.

Cardiomyopathy of pregnancy developed in a healthy primigravida at 34 weeks gestation and was followed two weeks later by the spontaneous delivery of a fresh stillbirth. An immunological basis underlying both the mother's condition and the fetal death was suggested by the presence of myocardial antibodies in maternal and cord blood. Reference is made to two other cases in which a similar pathological process may have occurred.

Adult↗