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Biomedical subjects

D M Hill

Publications and source records attributed to D M Hill.

31 records · Page 2Linked to original sources
PubMed1976

Correlation between serological and immunofluorescence results in the investigation of brucellosis in veterinary surgeons.

Four serological tests and three immunofluorescence tests for IgG, IgM, and IgA were compared for value in the investigation of brucellosis in veterinary surgeons. No one serological test stood out over the others, and the immunofluorescence tests did not appear to have advantages over the serological tests. If a laboratory is limited in time and resources then the saline agglutination or the complement fixation test would be reasonably satisfactory. The 2-mercaptoethanol test and the antihuman globulin (Coombs' test) have no advantages over the other two and could be dropped. Immunofluorescence tests are not recommended for routine testing of brucellosis sera. The results and these recommendations apply to the 'vet' sera tested; it is reasonable to suppose that what applies to 'vet' sera will also apply to sera of those who work with or are in repeated contact with cattle and who will have had previous experience of brucella antigen, that is, dairy farmers, herdsmen, or slaughter house employees.

Agglutination Tests↗
PubMed1975

Brucellosis and veterinary surgeons.

Forty-six veterinary surgeons were given a full clinical examination, serological examinations with estimates of immunoglobulins, and supplementary haematological and radiological investigations. Thirty-five complained of one or more symptoms, and eight had abnormal physical signs which might have been caused by infection with Brucella abortus, but neither sereological tests results nor immunoglobulin estimates bore any special relation to the clinical features. The soundest way of assessing ill health which had possibly been caused by brucellosis seemed to be thorough clinical examination and disregard of serologican findings. Interpreting results by the usual serological tests in the absence of a clinical examination is probably of doubtful value and may even be misleading.

Adult↗
PubMed1972

Subclinical Brucella infection in man.

Much subclinical infection with Brucella abortus affects the dairy farming community, slaughterhouse workers, and veterinary surgeons. High titres of antibody to B. abortus by the saline agglutination, antihuman globulin, or complement fixation test may be shown in subjects from the first two groups and generally there are no symptoms or signs of brucella infection whatever. Veterinary surgeons are prone to subclinical infection and young practitioners frequently display high titres against the usual tests at the same time apparently enjoying good health. Repeated reinfection of this group, however, may result in hypersensitivity to B. abortus and bouts of ill health at intervals may be due to this. Infection seems to come more often from contact with infected material than by drinking untreated milk, particularly in the herdsman, slaughterhouse worker, and veterinary surgeon. A doctor investigating illness of a patient from the dairy farming community and allied occupations should not accept a high titre against B. abortus as the only clue to diagnosis of the patient's condition.

Abattoirs↗
PubMed1970

Ketonaemia in uncontrolled diabetes mellitus.

Blood ketone bodies, serum insulin levels, and plasma free fatty acids were examined in a series of patients with "non-ketotic diabetic coma" and compared with the findings in ketoacidotic subjects. Serum insulin levels in six "non ketotic" patients ranged between 1 and 25 muu./ml. and were not significantly different from levels reported in patients with ketoacidosis. In addition, plasma free fatty acids were shown to be unrelated to the degree of ketonaemia. The investigation shows that neither the levels of serum insulin nor those of free fatty acids can explain the absence of hyperketonaemia in some cases.

Acetoacetates↗