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Biomedical subjects

D M Forrester

Publications and source records attributed to D M Forrester.

At least 19 recordsLinked to original sources
PubMed1997

Gorham's disease of the radius: radiographic, scintigraphic, and MRI findings with pathologic correlation. A case report and review of the literature.

A rare case of Gorham's disease affecting the radius in a 46-year-old woman is presented. It was studied by plain radiography, MRI, and scintigraphy, including three-phase radionuclide bone scan and thallium scan. Three-phase bone scan demonstrated slightly decreased activity in the affected portion of the forearm in the early phase, but showed increased activity on the blood pool and delayed imaging. A thallium scan revealed no abnormalities. Histopathologic examination revealed osteoclastic activity and scar tissue with minimal remaining vasculature.

Female↗
PubMed1996

Simultaneous occurrence of diffuse idiopathic skeletal hyperostosis and ankylosing spondylitis.

UNLABELLED: To the best of our knowledge, 10 cases of Ankylosing Spondylitis (AS) and Diffuse Idiopathic Skeletal Hyperostosis (DISH) coexisting in the same patient have been reported. A new case was found in a female patient at Los Angeles Medical Center in 1993, which we report in this paper. We also review the literature (Medline 1970-1994) and analyze the features of the reported cases. In order to study the incidence of this association in our population we have reviewed 106 cases of AS for radiological features of DISH. We found only one case. CONCLUSION: this is a rare association with an incidence of 0.94% in our patients with AS. From the known cases, patients showing this association present clinically mild AS in which radiologic findings are the basis for the diagnosis. Finally we question the validity of excluding the diagnosis of DISH in patients with radiological features of sacroiliac ankylosis.

Adult↗
PubMed1994

Multicentric giant cell tumor: report of five new cases.

The typical giant cell tumor (GCT) is a solitary neoplams that occurs in the epiphysis or epimetaphysis of long bones. GCT is seen with a slightly increased frequency in females, and 70% of patients are between 20 and 40 years of age at the time of presentation. Multicentric giant cell tumor (MGCT; two or more centers) is an unusual variant of GCT. Patients with MGCT are likely to be younger than those with a solitary lesion. The multicentric variety is often of a higher stage at diagnosis and is more often associated with a pathological fracture than the unifocal tumor. We are reporting five new cases of MGCT, with a total of 21 tumors seen over a period of 25 years from 1967 to 1992.

Adolescent↗
PubMed1994

Radionuclide imaging in forme fruste of melorheostosis.

Scintigraphy was instrumental in two histologically proven cases of forme fruste melorheostosis. Radionuclide bone scans demonstrated a moderately increased uptake of radiopharmaceutical localized to the "flowing" cortical hyperostosis of melorheostosis observed radiographically. The medullary portion of the affected bones showed no increase in tracer activity. In one case, imaging with Tl-201 chloride demonstrated increased focal activity of the lesion. These scintigraphic findings can help distinguish the mildest manifestation (forme fruste) of melorheostosis from the well-ossified lesions of myositis ossificans and parosteal or periosteal osteosarcoma. The findings of MRI are also described in one patient.

Adult↗
PubMed1993

Osteosarcoma presenting as intestinal obstruction.

Osteosarcoma commonly presents with osseous and pulmonary metastases. We present an unusual case of extraosseous metastatic abdominal chondroblastic osteosarcoma presenting as intestinal obstruction.

Abdominal Neoplasms↗
PubMed1992

Case report 749: Primary glomus tumor of bone.

We report a case of primary intraosseous glomus tumor in a 30-year-old man who was found to have an expanding, lytic lesion in the distal phalanx of his left thumb. The histological appearance was atypical in that areas of myxoid stroma resembled chondroid material. The unusual location and microscopic appearance caused diagnostic problems. Immunohistochemical studies, including strong positive staining for MSA and negative staining for keratin and S-100 protein, were helpful in establishing the correct diagnosis.

Adult↗
PubMed1991

Pro-oxidative interactions of dithranol with human phagocytes promote oxidative damage to DNA of bystander leucocytes.

Dithranol at therapeutic concentrations (5-40 micrograms ml-1) induced strand breaks in human leucocyte DNA in vitro in a dose-related manner. Leucocytes from individuals with chronic granulomatous disease (CGD) incurred substantially less DNA strand breaks than did normal leucocytes during exposure to dithranol indicating that activated phagocytes are involved. H-7, 4-beta-bromophenacyl bromide (BPB) and staurosporine, all inhibitors of protein kinase C, decreased both dithranol-mediated activation of the phagocyte respiratory burst and induction of DNA strand breaks. Similar effects were observed with the hydrogen peroxide scavenger catalase. These results suggest that dithranol induces DNA strand breaks, mainly as a result of pro-oxidative interactions with phagocytes.

Acetophenones↗
PubMed1990

Trauma to the foot.

Minor trauma to the foot may cause stress fracture, avulsion fracture or ligamentous and tendon injury. Plain radiographs are frequently normal. Radionuclide bone scan is a sensitive detector of early bone injury. A stress fracture may develop focal uptake or diffuse uptake throughout the bone involved. MR imaging is the most sensitive means of evaluating injury to the soft tissues. Acute edema, partial tear, complete tear, and chronic tendinitis have distinct features on T1- and T2-weighted images. Major trauma occurs most commonly as a result of falls from heights and from motor-vehicle accidents. Plain films are useful in the initial evaluation of the extent of trauma. CT is particularly useful in evaluating calcaneal fractures that involve the subtalar joint. Both MR imaging and CT scans are useful in detecting injured or entrapped tendons associated with fracture-dislocations.

Foot Injuries↗
PubMed1990

Magnetic resonance imaging of foot and ankle trauma.

MRI is a useful diagnostic tool in the assessment of traumatic lesions of the foot and ankle. It is especially useful in demonstrating acute and chronic tendon and ligament injuries. Subtle fractures, including osteochondral, nondisplaced, and stress fractures, are well shown with MRI but may be difficult to detect on radiographs. A bone scan may also be used to detect these fractures; however, with MRI the fracture extent may be determined. MRI is also useful in diagnosing complication of trauma, such as ischemic necrosis and bone and soft-tissue infections.

Ankle Injuries↗
PubMed1990

Imaging of the sacroiliac joints.

The sacroiliac joints present unique problems in diagnosis for both the clinician and the radiologist. Each of the imaging modalities presents advantages and problems. The specific clinical problems determine whether advanced imaging modalities such as scintigraphy, CT scan, or magnetic resonance imaging will complement the information on the plain radiographs.

Arthritis, Infectious↗
PubMed1986

Pancreatic acinar cell carcinoma with subcutaneous and intraosseous fat necrosis.

On rare occasions, excessive lipase production by functioning pancreatic acinar cell carcinoma results in subcutaneous and intraosseous fat necrosis. A patient with subcutaneous nodules and osteolytic lesions from metastatic fat necrosis associated with this malignancy is reported. Prompt recognition of the syndrome led to complete resection of the otherwise asymptomatic neoplasm of the exocrine pancreas.

Aged↗