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Biomedical subjects

D M Becroft

Publications and source records attributed to D M Becroft.

At least 91 records · Page 5Linked to original sources
PubMed1973

Benign sinus histiocytosis with massive lymphadenopathy: transient immunological defects in a child with mediastinal involvement.

A 16-month-old boy presented with cervical lymphadenopathy and a mediastinal mass causing tracheal displacement. Treatment of what at first was suspected to be a malignant neoplasm was limited to low-dose irradiation of the mediastinum and biopsy excision of the cervical lymph nodes. There has been no recurrence of disease in the subsequent four years. The pathological features and clinical course correspond to a benign disease first described in 1969 in which there is massive proliferation of histiocytes in lymph node sinuses. No infectious cause was identified. Consistent but eventually reversible defects in lymphocyte response to phytohaemagglutinin and in augmentation of nitro-blue tetrazolium reduction by neutrophils during phagocytosis were demonstrated in the patient and in his monozygous twin. These defects in cellular immune function are believed to be important in the pathogenesis of the histiocytosis.

Child, Preschool↗
PubMed1971

Epidemic listeriosis in the newborn.

Within a three-month period 13 cases of listeriosis in the newborn were seen at the National Women's Hospital, Auckland. Eleven presented in the first 24 hours of life, the most common feature being respiratory difficulty in low birth weight infants. Meconium-stained liquor was noted in nine cases. The constant finding in all cases was an aspiration pneumonia which appeared to be of intrauterine origin from an infected amniotic cavity. There was also evidence of septicaemia in nine cases, and two infants survived meningitis which developed at 1 week. Maternal symptoms were mild and variable, and in only one case were they proved to be due to listerial infection. The mothers came from different suburbs of Auckland and no common source of infection was found.

Apnea↗
PubMed1971

Bronchiolitis obliterans, bronchiectasis, and other sequelae of adenovirus type 21 infection in young children.

A remarkably high incidence of bronchiectasis and other pulmonary sequelae was observed in young children affected during an epidemic of severe lower respiratory tract infections apparently caused by adenovirus type 21. The histopathological findings are described in four cases in which one or both lungs were obtained for examination at intervals ranging from two months to three years after the acute infections. Widespread bronchiolar obliteration (bronchiolitis obliterans) was a striking finding in all four. The severity of bronchial inflammation and of bronchiectasis was proportional to the time elapsed since the acute infections. Bronchiolar obliteration is a likely sequel of the necrotizing bronchiolitis which may occur during acute adenovirus infections. The role of bronchiolar obliteration in the pathogenesis of bronchiectasis and other chronic lung disease is discussed. Adenoviruses may be a major cause of post-infectious bronchiectasis in childhood.

Acute Disease↗
PubMed1967

Histopathology of fatal adenovirus infection of the respiratory tract in young children.

Type 7 adenoviruses were isolated from lung tissue obtained at the necropsies on five children aged 8 to 15 months. The clinical and radiological findings were those of bronchiolitis and pneumonia. Four children had an extensive necrotizing bronchitis and bronchiolitis. The surviving bronchial epithelium, and all bronchial epithelium in the fifth case, was proliferating. There was evidence that this proliferation was a virus-induced effect and not reparative. There was virus tropism to alveolar lining cells with a pneumonia showing mononuclear cellular reaction, necrosis, and hyaline membranes. Distinctive necrotizing lesions were found in the bronchial glands of all cases. Two contrasting types of intranuclear inclusions were present in all lesions and their significance and inter-relationships are discussed. These pathological changes are specific for infections by a limited number of adenovirus serotypes.

Adenoviridae↗