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Biomedical subjects

D Lynch

Publications and source records attributed to D Lynch.

10 recordsLinked to original sources
PubMed1978

Rorschach suicide predictors: a crossvalidational study.

Attempted to replicate previously reported findings that individuals who commit suicide give a greater number of transparency and cross-sectional responses on the Rorschach than matched nonsuicidal Ss. In addition, a variety of other scoring categories reported in the literature as being more frequent in suicidal Ss were compared for suicidal individuals and their matched controls. However, neither the transparency and cross-sectional category nor the other response classifications differentiated the groups. Social class and/or IQ differences in the samples used were suggested as a reason for the failure to replicate the earlier study on cross-sectional and transparency scores.

Adult↗
PubMed1978

Secretory immunity and immunodeficiency.

1) Certain selective IgA-deficient subjects are capable of synthesizing functional secretory antibodies (s-IgM or s-IgA class) to indigenous oral microorganisms. 2) The presence or absence of these secretory antibodies in saliva can be correlated with the extent of caries involvement. 3) Lysozyme activity is significantly increased in saliva from immune deficient subjects though no correlation can be made with caries experience.

Agammaglobulinemia↗
PubMed1977

Molecular and genetic approaches to the analysis of the informational content of the mitochondrial genome in mammalian cells.

Our laboratory has been involved in the last few years in investigations aiming at analysing by molecular approaches the informational content of the mitochondrial genome in mammalian cells and the mechanisms and control of its expression, H eLa cells and other mammalian cell lines have been utilized for these studies. These investigations, as well as work carried out in other laboratories, have yielded a considerable amount of information concerning the mechanism, products and regulation of transcription of mitochondrial DNA (mit-DNA), the apparatus and products of mitochondria-specific protein synthesis in animal cells, and the number and topology of the sites on mit-DNA which code for the primary gene products identified so far. It is the purpose of the present report to summarize the latest observations in this area, as well as some recent results on the isolation and characterization of chloramphenicol-resistant variants of a human cell line. Reference is made to previous review articles 1,2,3 for the earlier work.

Amino Acyl-tRNA Synthetases↗
PubMed1976

An electron microscope study of the relative positions of the 4S and ribosomal RNA genes in HeLa cells mitochondrial DNA.

The 4S RNA genes in HeLa mitochondrial DNA (mtDNA) have been mapped by electron microscopy using the electron-opaque label ferritin. This method is based on the high affinity interaction between the protein, avidin,and biotin. 4S RNA, covalently coupled to biotin, was hybridized to single-stranded mtDNA. The hybrids were then labeled with ferritin-avidin conjugates. The positions of ferritin-labeled 4S RNA genes were determined relative to the rRNA genes on both heavy (H) and light (L) strands of mtDNA. This region was recognized as a duplex segment after hybridization either with rRNA in the case of H strands or with DNA complementary to rRNA in the case of L strands. Our studies suggest that at least nineteen 4S RNA genes are present in the HeLa mitochondrial genome. On the H strand, we have confirmed the nine map positions found in a previous electron microscope mapping study (Wu et al., 1972) and obtained evidence for three additional 4S RNA genes. On the L strand, seven 4S RNA genes have been mapped. The nineteen genes are distributed more or less uniformly around the genome. There is a pair of closely spaced genes, approximately 150 nucleotides apart, on the H strand, and another closely spaced pair on the L strand.

Chromosome Mapping↗
PubMedDate not supplied

Family genograms.

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Family↗