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Biomedical subjects

D Levin

Publications and source records attributed to D Levin.

95 records · Page 6Linked to original sources
PubMedDate not supplied

A public health response to emerging technology: expansion of the Massachusetts newborn screening program.

The development of a new technology, called tandem mass spectrometry (tandem MS), has challenged governments worldwide to consider expanding universal newborn screening for rare metabolic disorders. In 1997 the Massachusetts Department of Public Health developed a public process to meet this challenge. After addressing significant medical, legal, ethical, and logistical issues raised by tandem MS, Massachusetts incorporated one new disorder into the mandatory newborn screen and developed an optional pilot program for 20 additional disorders. The Massachusetts experience has wide relevance for other nations and states. As screening protocols are contemplated for entire populations-for newborns and others- it will remain essential that the public participate in an open process of reviewing the justification for and logistics of screening.

Ethics, Medical↗
PubMedDate not supplied

The cost-effectiveness of same-day admission surgery.

The move toward outpatient and same-day surgical services has been phenomenal in recent years. In this study comparing same-day and traditional surgery patients in a Midwest tertiary care center, hospital charges and costs were significantly lower for same-day surgery patients. These differences reflected decreased lengths of stay and reduced ancillary services.

Adult↗
PubMedDate not supplied

Electrophysiological effects of low dose alcohol on human subjects at high altitude.

Low dose alcohol significantly altered auditory evoked potentials in normal human subjects. Effects of alcohol were studied on the P50 evoked potential wave following click stimulation, which was presented in a conditioning-testing paradigm. The conditioning-testing paradigm uses paired stimuli to demonstrate inhibitory sensory gating, measured as suppression of the amplitude of the second or "test" response following the first or "conditioning" response. Alcohol at blood levels under 0.1 g per dl caused significant decrement in the size of the P50 wave in the initial conditioning response and also decreased the suppression normally seen in the conditioning-testing paradigm. These data suggest that low doses of alcohol affect both the excitatory mechanisms responsible for the formation of the P50 wave in the conditioning response and the inhibitory mechanisms responsible for its suppression in the test response. Nine of the 17 subjects studied using this paradigm were recorded both at Denver, Colorado (5,280 feet above sea level) and on Mt. Evans (14,264 feet above sea level). Despite the commonly held belief that alcohol causes more intoxication at high altitudes there was no significant difference in the effects of alcohol on evoked potentials in these subjects at these two attitudes.

Adult↗