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Biomedical subjects

D Lester

Publications and source records attributed to D Lester.

At least 1,063 records · Page 59Linked to original sources
PubMed1970

Alcohol oxidation in rate inhibited by pyrazole, oximes, and amides.

Pyrazole, previously reported to inhibit ethanol oxidation in the rat, also effectively blocks the in vivo metabolism of methanol, propanol, isopropanol, n-butanol, and isobutanol. A variety of oximes and amides are also effective inhibitors of ethanol metabolism. These various inhibitors may prove important in the elucidation of several facets of alcohol metabolism and also may have application in the treatment of methanol poisoning and in the reduction of the sequelae of the disulfiram-ethanol reaction syndrome in man.

1-Propanol↗
PubMed1970

Alcohol aversion in the rat: behavioral assessment of noxious drug effects.

Injections of p-chlorophenylalanine or n-butyraldoxime given after rats were first given a 10-minute drinking test with saccharin or ethanol solutions produced a learned aversion to these solutions. These findings suggest that the reduced self-selection of alcohol (preference) resulting from the administration of these drugs, reported by others, is not specifically alcohol-related. The technique described offers a sensitive procedure for the assessment of unpleasant effects of drugs.

Alcohol Deterrents↗