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Biomedical subjects

D Leroy

Publications and source records attributed to D Leroy.

At least 109 records · Page 6Linked to original sources
PubMed1993

[Psoriatic onycho-pachydermo-periostitis].

Psoriatic-onycho-pachydermo-periostitis is a particular form of psoriatic arthropathy recently described, which combine psoriatic onychosis, thickening of the distal soft tissues and osteo-periostitis of the distal phalanx without lesion of the interphalangeal joint. Biological examinations are normal. Radiological lesions show a phalanx condensation which gives a spicule aspect. Two cases of onycho-pachydermo-periostitis are described. We report the first one with all the fingers and toes concerned.

Acrodermatitis↗
PubMed1992

[Idiopathic light eruption].

Idiopathic polymorphous light eruptions (PLE) are photodermatites due to an as yet unidentified photosensitizing agent. Benign estival PLE is the most frequent form: the face is spared, and as soon as the patient has acquired a slight tan the eruption will no longer occur. Juvenile spring eruption affects the free border of the helix and may be regarded as a localized and mild form of estival PLE. Polymorphous light eruptions appear as lesions of the face which may resemble lupus erythematosus; photobiological exploration reproduces the lesions experimentally in 70% of the cases; immunohistochemistry studies are in favour of an immunological mechanism. Solar urticaria is a rare physical urticaria started by UVA, UVB and/or visible light: tolerance to sunlight can be induced by repeated exposures, but it does not last. Hydroa vacciniform is a rare PLE in children with leaves smallpox-like scars; photobiological exploration reproduces the lesions with high doses of UVA applied for 3 consecutive days. The remanent photosensitivity syndrome is characterized by an extreme photosensitivity which may be very disabling, preventing the patient to go outdoors; photo-allergological exploration discloses numerous positive patch-tests or photopatch-tests to various allergens, but the role played by these allergens in the occurrence of photosensitivity remains unclear. The syndrome probably results from an exogenous photosensitivity accident that has not regressed after exclusion of the presumably responsible photoallergens. Many treatments tested for these PLE seem to be effective, but they have not yet been controlled by double-blind trials.

Humans↗
PubMed1991

Morphological and biochemical characterization of the opossum kidney cell line and primary cultures of rabbit proximal tubule cells in serum-free defined medium.

Proliferation, morphology and time course patterns of marker enzyme activities of primary cultures of renal rabbit proximal tubule cells (RPT cells) and Opossum kidney cells (OK cells) in antibiotic-free and serum-free defined medium were investigated. Both RPT and OK cells grew to confluency within 6-8 days. RPT cells were thicker and displayed higher density of both microvilli and mitochondria when compared with OK cells. RPT cells exhibited higher activity of glutathione-S-transferase when compared with OK cells, whereas in the latter, higher glutathione content could be detected. Apical and basolateral membrane enzymes were higher in RPT cells than in OK cells. Stable high glycolytic activity and low gluconeogenesis activity in OK cells pointed out a strict dependence on glycolysis, whereas RPT cells exhibited glucose metabolism shift towards the glycolysis pathway.

Animals↗
PubMed1991

Sweet syndrome associated with acute myelogenous leukemia. Atypical form simulating facial erysipelas.

A case of Sweet syndrome in a patient with an acute myelomonocytic leukemia is reported. It is an unusual case simulating a facial erysipela. This case illustrates the difficulty in differentiating infection from Sweet syndrome in an immunocompromised patient. The negative cultures, ineffective antibiotics, and histopathologic examination results allowed the onset of corticosteroid therapy. The phagocytic function of the neutrophils studied by chemoluminescence was normal in the patient. The physiopathology of Sweet syndrome is discussed, in particular the role of cytokines in the accumulation of granulocytes.

Adult↗
PubMed1991

Psoralen plus ultraviolet A in the prophylactic treatment of benign summer light eruption.

We report the results of a French multicentre study to evaluate the efficiency of psoralen plus ultraviolet A (PUVA) therapy in the prophylactic treatment of benign summer light eruption (BSLE) and to establish the optimal protocol of radiation. Nine photobiology centres took part in this study; 83 patients (76 of them women) were evaluated. The radiation protocols were as follows: oral psoralen (8-methoxypsoralen; 0.6 mg/kg) was taken at each session; the starting dose of UVA radiation was determined according to skin type, with increments of 0.5 J/cm2 every 2 sessions. The subjects were randomized to receive 10-20 sessions 3 times per week. PUVA therapy was very effective: 68 patients (82%) reported total protection from BSLE. Four patients (5%) showed progress. Only 13% showed no improvement. The satisfactory results were not correlated with either the number of sessions or the J/cm2 of UVA. The intensity of tanning after the PUVA sessions did not appear to predict cure. Thirty-six percent of the patients had adverse reactions to treatment, including erythema, pruritus and triggering of BSLE. However, these effects only required the treatment to be stopped in 2% of the cases (for severe pruritus). The results in the various centres were similar.

Adolescent↗
PubMed1990

Belgian general practitioners on their vocational training: a postal inquiry.

Vocational training of general practitioners in Belgium consists--among others--of 34 seminars to be followed in small groups during a period of two years. The purpose of this study was to develop an instrument for continuing evaluation of this system, and to gather evaluative data. 58% of 177 young general practitioners responded to our postal inquiry, in which ten open-ended questions were put, and 50 statements were to be rated on a six-point-scale. The inquiry revealed that the Belgian vocational training has a large influence on the evolution from inexperienced young doctor to self-confident general practitioner. Factor analysis on the scores of the 50 statements uncovered three dimensions: (1) working climate, (2) learning results, and (3) identification. The reliability of the scales, constructed for each of these factors, was between 0.80 and .86 (Cronbach's alpha). Mean scores on these scales were all high. The Belgian vocational training seems to be accepted and appreciated by the young GPs, but improvements might be suggested.

Attitude of Health Personnel↗
PubMed1989

Aneurysm associated with chronic mucocutaneous candidiasis during long-term therapy with ketoconazole.

A little girl who was suffering from chronic mucocutaneous candidiasis also had a cellular immune deficiency and undetectable IgA levels. She was treated continuously for 6 years with ketoconazole at the same dosage of 200 mg/day. She was rapidly clear from infection and did not relapse although her immune abnormalities persisted. During this long-term therapy, voluminous fusiform intracranial aneurysm appeared, causing a paresis of the four limbs. Are they mycotic aneurysms?

Adult↗
PubMed1989

[Malignant eccrine poroma. Apropos of 2 facial sites].

The authors report 2 cases of malignant eccrine poroma (M.E.P.) located on the face: one on the auricle which was treated by triangular shape resection, the other on the nasal tip which underwent a reconstruction with a Converse scalping flap after large surgical resection removed underlying skin and cartilages. A study reviewing the main features of M.E.P. is presented on the basis of these clinical cases. M.E.P. are skin appendage tumors originating from the intra epithelial portion of the eccrine sweat duct. Such denominations as malignant hidroancanthoma, eccrine porocarcinoma, poroepithelioma, correspond to the same tumor. They are very rare: 73 cases have been reported in the world literature with only 12 located on the face; the main localisations involve the lower extremities, but the palmo plantar areas are involved more frequently in benign tumors. Elderly people over 60 are concerned in almost all cases. Many of the patients have noticed a lesion for years before a diagnosis was made suggesting one of the etiopathogenic theories that M.E.P. may result from malignant transformation of a benign eccrine poroma. Their clinical appearance is non specific nevertheless their malignant nature is suspected and misdiagnosis with basal cell carcinoma is frequent. Microscopic findings demonstrate the diagnosis by showing the association of malignant features with eccrine poroma. These tumours invade both by superficial spead and by deep extension towards dermal and hypodermal structures. Their prognosis is marked by the rapid development, in approximately on half of cases, of cutaneous, lymp node and visceral metastases. Clinical and histological examination have no prognostic value exception the case of deep invasion.(ABSTRACT TRUNCATED AT 250 WORDS)

Adenoma, Sweat Gland↗
PubMed1989

[Immunologic diagnosis of the cerebrospinal fluid and serum in developing brain cysticercosis].

ELISA detection of specific antibodies in the serum (IgG) and cerebrospinal fluid (IgG, IgM and IgA) was evaluated in 28 patients. Diagnosis of cerebral cysticercosis and evaluation of disease activity was based on CT scan findings. Specific IgG antibodies were found in the serum in 83.3% of patients with active disease and 10% of those with inactive disease. Cerebrospinal fluid tests evidenced specific antibodies in all patients with active disease and none of the patients with inactive disease. The specific CSF antibodies were IgG (94.4%), IgM (66.6%) or IgA (66.6%). Antibody titers were significantly higher in patients with an intraventricular vesicle or cyst.

Adolescent↗