Biomedical subjects
Publications and source records attributed to D Leroy.
A normal infant was born to a 25 year-old mother with phenylketonuria who had never been treated. The mother had been fed a phenylalanine restricted diet for 3 months before the beginning of the pregnancy. Dietary control was maintained throughout the whole gestation. The problems of dietary control in a mentally retarded woman are analysed.
In reference to a typical case of Buerger's disease, the clinical, arteriographic, histological signs as well as diagnostic criteria are restated. The pathogenesis is still unknown; a genetic predisposition and an auto-immune process could be involved. The treatment, presently symptomatic, cannot arrest the evolution which is often mutilating, when the patient continues to smoke. An early diagnosis is possible in the presence of superficial phlebitis or Raynaud's phenomenon.
With the aim of determining criteria by which results of a sclerosant treatment could be assessed in a multicentric study, 35 sapheno-femoral junctions (26 long saphenous veins and 9 short saphenous veins) treated by sclerotherapy beforehand, were controlled separately and confidentially by two examiners, first clinically, then using the Doppler. The concordance rates were analysed for each of the tests carried out: fascial palpation, clinical and ultrasound percussive permeability, clinical and ultrasound search for reflux, measurement of length of reflux. The results confirm the superiority of the Doppler technique, both in the diagnosis of ostial permeability and reflux (concordance superior at 90% as opposed to 68 to 80% for the clinical tests), and in the quantification of the reflux (strong positive correlation, r = 0.83, between the values given by the two examiners). The doppler technique provides an excellent concordance of differentiated clinical sensibility between the examiners. The permeability, by Doppler, and the length of the audible reflux are proposed as criteria for assessment of the result of a sclerosant treatment, during the follow-up.
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HbA1c percentage was determined in 82 insulin-dependent juvenile diabetic patients. The concentration of HbA1c reflects the level of chronic hyperglycaemia during the preceding 4 to 8 weeks and appears to correlate closely with the commonly used methods for monitoring diabetic control. HbA1c measurement provides a reliable and objective test for periodic assessment of insulin-dependent juvenile diabetes. It may serve as a valuable tool for determining the level of metabolic control in each patient and measuring the effectiveness of various therapeutic regimens.
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