Biomedical subjects
Publications and source records attributed to D Lefebvre.
Urinary tract infection was shown to be both common and serious in the postoperative period. Among 87 patients who underwent urinary catheterization immediately before or after surgery, 28 (32%) had urinary tract infection. Urinary tract catheterization is necessary in some instances but rapid removal and routine culture of catheters is requisite.
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More than a common descriptive interest, this researches about vasa-vasorum have been carried on to give some anatomical basis, to the part acted by those vessels in arterial wall life. Microdissections, X-rays diaphanisation enable us to systematize even in human kind than in animal species, the main aspects of this vascularisation. The conception of a double irrigation, from the lumen and from the vasa of the blood vessels, and the presence of a venous and lymphatic drainage, can give us the basis of an interpretation of the beginning of the main arterial diseases.
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In vivo studies were carried out in young Sprague-Dawley rats to examine the role of gastric lipolysis on fat absorption and bile acid metabolism. When fed by gastric perfusion 5 times (corn oil, 4 g/day) their usual dietary intake of fat, rats deprived of lingual lipase by the creation of an esophageal fistula had a significant degree of fat and bile acid malabsorption as well as a shortened bile acid half-life when compared to animals with a gastrostomy. The % fat absorption, bile acid loss and bile acid pool were normal in 2 groups of esophageal fistula rats fed the same quantity of corn oil or twice (8 g/day) that amount as a fine emulsion. In view of a negligible gastric lipase activity in animals with an esophageal fistula and of decreased hydrolysis of a triglyceride test meal, these data suggest that gastric lipolysis is of physiological importance in situations where lipolytic mechanisms are stressed by a large fat intkae. Its principal role is to potentiate intestinal lipolysis by facilitating the emulsification of dietary lipids through its formed products and, therefore, the contact of pancreatic lipase with its substrates.
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The authors introduce the concept of covering myoplasty in the treatment of infected cutaneous vascular prosthesis, either in the inguinal region or in the abdominal portion of an axillo-femoral graft. After describing their technique, they briefly review the main procedures described up to the present time and the potential role of myoplasty.
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An antiserum to chicken soluble thymic factor (STF) was prepared in rabbits and absorbed with chicken thymocytes until it reacted only with thymic reticuloepithelial cells. When injected into 6-day-old embryonated eggs, this antiserum caused a severe depletion of small lymphocytes in the cortical region of the thymus which was filled with large undifferentiated cells. In addition, reticuloepithelial cells displayed a marked disruption of cytoplasmic elements. The percentage of thymic lymphocytes bearing the T antigen was greatly reduced. It is believed that a factor responsible for differentiation of stem cells into T cells has been inhibited.
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