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Biomedical subjects

D Lee

Publications and source records attributed to D Lee.

At least 595 records · Page 33Linked to original sources
PubMed1981

Serum prolactin during pregnancy induced by pituitary gonadotrophins in a patient with post partum hypopituitarism (Sheehan syndrome).

With the purpose of investigating if placental prolactin production had an influence on maternal prolactin serum concentrations, this hormone was quantitated in serum of a women with partial Sheehan syndrome (deficient gonadotrophin and prolactin production). Her pregnancy was induced by pituitary gonadotrophins and the deficient prolactin pituitary reserve was shown by means of pituitary stimulation test with metoclopramide of pituitary stimulation test with metoclopramide and TRH. Quantitative analysis of prolactin was made by RIA utilizing the double antibody method. Serum prolactin concentrations remained persistently low during pregnancy with a minimal increase (1 - 16 ng/ml) at the end of pregnancy when comparing with concentrations observed in normal pregnant women (20 +/- 10 ng/ml at the beginning of pregnancy, and 250 +/- 150 ng/ml mean +/- 3 SD at the end). Prolactin concentration in the umbilical cord was found to be within normal values (252 ng/ml). Results obtained showed that fetal and placental prolactin does not pass on to the mother and confirm the idea that maternal serum prolactin during pregnancy is exclusively of a maternal pituitary origin.

Adult↗
PubMed1980

Acute caecal volvulus.

Forty-one cases of acute caecal volvulus have been analysed. The diagnosis is rarely made on clinical grounds alone but plain radiography of the abdomen should suggest the diagnosis in nearly 90 per cent of cases. Prompt surgery is imperative. When the bowel is viable, simple caecopexy combined with tube caecostomy is effective in fixing and decompressing the bowel in the short term and prevents recurrence.

Acute Disease↗
PubMed1980

Gastric pseudolymphoma.

Six histologically proved cases of gastric pseudolymphoma are described. This uncommon benign condition often simulates ulcerated gastric carcinoma radiologically, and pathologically it may cause considerable confusion with malignant lymphoma. Recognition of this condition is important to prevent unnecessary and often hazardous treatment whether by surgery or radiotherapy and to prevent inclusion in series of malignant gastric lymphoma, so that falsely high survival rates are not recorded.

Adult↗
PubMed1980

Structure-function of the factor VIII complex studied with an immobilized heteroantisera to VIII:C.

An antibody was raised in rabbits to the small active fragment of human factor VIII, obtained by Ca2+ dissociation of a human factor VIII preparation made from a multidonor plasma pool. After absorption, the antibody neutralized the factor VIII coagulant activity of normal human plasma, but did not precipitate with any plasma or plasma fractions or neutralize von Willebrand factor (vwf) activity as measured by ristocetin aggregation of fixed washed platelets. Immune beads were prepared by CNBr binding of the partially purified rabbit antibody to 1% agarose beads. Non-immune beads were prepared with IgG fractions obtained from the rabbits before immunization and used throughout as a control. The amount of factor VIII coagulant activity (VII:C) removed from plasma by immune beads was time-dependent and proportional to the amount of beads used, but all of the VIII:C could not be readily removed. Removal of VIII:C by immune beads parallelled removal of factor VIII:antigen, but less VWF activity was removed. Immune beads could be blocked or saturated by treatment with large amounts of normal plasma, but not by von Willebrand disease plasma and only by some haemophilic plasma.

Absorption↗
PubMed1980

Later stages of development of the periotic duct and its adjacent area in the human fetus.

The later stages of development (16-40 weeks in utero) of the periotic duct and its adjacent areas in the human fetus indicate that the critical stages of development occur in four specific time related stages over a six-week period (20-26 weeks). First, the petrous apex ossifies to separate th inferior cochlear vein into the canal of Cotugno and forms the medial wall of the cochlear aqueduct (22 weeks); second, the canalicular otic capsule fuses with the cochlear otic capsule to obliterate Hyrtl fissure and forms of the lateral wall of the cochlear aqueduct (24 weeks); third, progressive bone deposition to the medial surface of the membranous labyrinth and cochlea at the petrous apex elongates the periotic duct and cochlear aqueduct (32 weeks in utero); and fourth, active arachnoid tissue ingrowth into the periotic duct occurs at 20-24 weeks and 34-40 weeks in utero. The terminal event is widening of the CNS opening of the periotic duct at 32 weeks in utero. The periotic duct and cochlear aqueduct length increase with gestation from 25 weeks until term. The periotic duct width remains the same throughout the gestation. The cochlear aqueduct width diminishes with gestational age. The periotic duct remains patent throughout 16-40 weeks in utero.

Cochlea↗
PubMed1980

Influence of fibrinogen levels in dogs on mortality from hemorrhagic and traumatic shock.

1) Fibrinogen levels appear related to the outcome of hemorrhagic shock in dogs. 2) Fibrinogen levels can vary with different animals based on location, disease, stress, nutrition, or other factors. 3) Any experiments in hemorrhagic shock (or anything else) should utilize simultaneous and paired controls of animals from the same source or they may be subject to major error.

Animals↗
PubMed1980

High perfusion pressure damages the sieving ability of sinusoidal endothelium in rat livers.

Fenestrated endothelium lining liver sinusoids forms an ultrastructural sieve between blood and hepatocytes which at physiological perfusion pressures has previously been shown to shield hepatocytes from large triglyceride-rich chylomicrons. In the study reported in this paper, enlargement of endothelial fenestrae at high perfusion pressures has been confirmed and a concurrent increase in trapping of large chylomicrons by the liver noted. These findings suggest the importance of employing physiological perfusion pressures in studies designed to examine hepatic lipoprotein metabolism and also suggest a possible mechanism in the pathogenesis of fatty change seen in the "nutmeg" liver of chronic venous congestion.

Animals↗