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Biomedical subjects

D LeGrady

Publications and source records attributed to D LeGrady.

5 recordsLinked to original sources

The Nebraska Medicaid Drug Utilization Review Program.

There are reports in the literature which address the effects of DUR on morbidity and cost containment in a non-acute setting. Most of the information, however, is under acute care circumstances. Some of the studies performed under these situations have shown added benefits in terms of patient care. This article attempts to document similar changes in morbidity and cost containment in a relatively ambulatory Medicaid population. It must be remembered that the Medicaid population in Nebraska is composed of some patients who are institutionalized in a variety of settings. In 1989, the Medicaid population had an average age close to 65. Forty-three percent of these patients resided in a nursing home and may have either received hospitalization as a result of a Drug Therapy Problem or incurred added expenses while maintaining residency in a long-term care environment. The cost savings noted here do not reflect other factors such as the effects of age, race, gender, residential status, diet, smoking, exercise, disease prior to Medicaid enrollment, etc. This estimate does not take into account the effects of increased ingredient or administrative costs. Any increases in claims amount over time would tend to boost cost savings while increases in administrative expenses would tend to blunt this effect. If an adjustment was made for age, gender and other factors, cost-savings could be affected. Additionally, the DUR program does not include any drug effects which could be attributable to changes in other prescribed medications secondary to the original inquiry.(ABSTRACT TRUNCATED AT 250 WORDS)

Cost Control

Coffee consumption and mortality in the Chicago Western Electric Company Study.

The relations between coffee consumption and 19-year mortality from all causes, coronary heart disease, and non-coronary causes were assessed in 1,910 white males aged 40-56 years in 1957-1958 from the Chicago Western Electric Company Study. Mortality rates, adjusted for age, serum cholesterol, diastolic blood pressure, and smoking status, were compared for those consuming 0-1, 2-3, 4-5, and 6+ cups of coffee per day; coffee intake, measured at the first anniversary examination, included both caffeinated and decaffeinated intake. Mortality from all causes was greatest in the highest and lowest intake groups. The increased mortality in the 6+ cups per day group was due to coronary heart disease, while the increased mortality in the lowest intake group was due to noncoronary causes. The adjusted relative risk of coronary heart disease death for those drinking 6+ cups of coffee per day compared with those drinking less was 1.71 (95 per cent confidence limits 1.27, 2.30). This increased risk of coronary heart disease death was present in both smokers and nonsmokers, with adjusted relative risks of 1.62 and 2.21, respectively (95 per cent confidence limits 1.17, 2.24 and 1.06, 4.62). The increased mortality from non-coronary causes in the lowest intake group was due primarily to increased mortality from cancer and cardiovascular diseases other than coronary heart disease. The results of this study support the hypothesis that those who drink 6+ cups of coffee per day may be at an increased risk of death from coronary heart disease.

Adult

A randomized trial on the effect of decreased dietary sodium intake on blood pressure in adolescents.

A randomized crossover trial on the effect of salt restriction on blood pressure was carried out involving 124 adolescents (mean age 16 years). Dietary sodium was reduced from approximately 110 to 45 mEq/24 h for a period of 24 days. Blood pressure was non-significantly lower at the end of the experimental diet for all participants. A slight (0.7 kg), yet statistically significant fall in weight was observed (P less than 0.05). Subgroup analysis demonstrated that participants whose body mass index was below the median had a statistically significant fall in systolic blood pressure (P less than 0.05); fall in weight and increase in heart rate were also more pronounced in the less obese individuals. It would appear that moderate sodium reduction does not have an overall short-term effect on blood pressure in normotensive adolescents. However, body size as reflected in body mass index may influence blood pressure response to sodium reduction.

Adolescent

Increased sodium-lithium countertransport in college students with elevated blood pressure.

Blood pressure screening was carried out on a university campus to identify early hypertension or high-normal BP in young adults. Compared with normotensive control subjects of a similar age, drawn from the same population, persons identified as being at the upper end of the BP distribution had significantly increased levels of sodium-lithium countertransport. This difference persisted when other potential confounding variables, eg, overweight, sex, ethnicity, sodium excretion, and age, were taken into account. A positive family history was associated with slightly higher levels of sodium-lithium countertransport, although the effect could be explained by higher present levels of BP. These data suggest that abnormalities of cation transport are present early in the course of the development of hypertension. Measurement of transport levels may provide an estimate of risk of hypertension and allow identification of susceptible persons.

Adult