Biomedical subjects

D Laufer

Publications and source records attributed to D Laufer.

150 records · Page 9Linked to original sources

PubMedDate not supplied

Oral Candida carriage and blood group antigen secretor status.

Oral Candida carriage and blood group antigen secretor status were examined in 92 healthy, young volunteers. Candida was isolated from 61 of 92 saliva samples (66% Candida carriage). In 76% of cases this was Candida albicans. Oral Candida carriage was found to be significantly associated with non-secretion of blood group antigens (P < 0.05). However, the numbers of Candida were higher in the saliva of secretors than of non-secretors (P < 0.01). A higher percentage of Candida carriage was observed in individuals with blood group O. Thus, the finding of higher carrier frequency in the non-secretors and in blood group O subjects is confirmed.

ABO Blood-Group System↗

PubMedDate not supplied

Genioglossal advancement--a simple surgical procedure for sleep apnea. Case report and literature review.

Although the use of a standard nasal continuous positive airway pressure device to combat obstructive sleep apnea is often effective, it is neither curative nor universally well tolerated. Thus, surgical intervention is often inevitable. We describe a simple, conservative surgical procedure performed on a patient with profound mandibular retrognathia (dolichofacial type), accompanied by sleep apnea. The procedure resulted in a significant pharyngeal airway enlargement of 53 and 87% at the mandible angle and hyoid bone levels, respectively, increased oxygen saturation, reduction in the respiratory disturbance index by 50%, and improved sleep quality. We present a procedure for patients whose sleep apnea is due to extensive mandibular retrognathism with concomitant retrolingual narrowing and collapse.

Adult↗

PubMedDate not supplied

Sarcoma of the maxillofacial region: follow-up of 25 cases.

BACKGROUND: Maxillofacial sarcomas are rare tumors, varying according to their type, grade, site of occurrence, response to treatment and prognosis. Approximately 10% of all cases of osteosarcoma, a subtype with a particularly poor prognosis, occur in the head and neck. PATIENTS AND METHODS: During the 35 years from 1963 until 1997, the 25 patients treated for sarcomas at our center were identified and evaluated according to a variety of parameters. RESULTS: Overall 2- and 5-year survival rates were 72% and 60%, respectively. Sarcomas were found most commonly in the mandible, maxilla and tongue. Survival was not significantly correlated with gender, ethnic origin or histopathological staging, but significant correlation was found between type of sarcoma and survival whilst younger patients had better survival rates. CONCLUSION: Advanced facial reconstruction methods may enable the performance of more radical ablative surgery, thereby improving survival outcome for head and neck osteosarcoma patients. Osteosarcoma appears to be as lethal in the maxillofacial region as in the extremities.

Adolescent↗

PubMedDate not supplied

Invading basal cell carcinoma of the jaw: an under-evaluated complex entity.

Basal cell carcinoma (BCC) is a locally invasive neoplasm, rarely metastatic, yet capable of significant local destruction and disfigurement. Invasion into the bone is uncommon and only a few cases of invasion into facial bones, but never to the mandible or maxilla, have been described. We report three patients with BCC lesions invading their jaws, as a consequence of which either their mandible or maxilla had to be partially resected. This resulted in facial mutilation which required comprehensive multi-disciplinary therapy to restore function and esthetics. Such therapy requires a combination of modalities offered by both plastic and maxillofacial surgeons, as well as oral and dental rehabilitators.

Adult↗

PubMedDate not supplied

Lead levels in teeth of long date and new immigrants in several cities in Israel--preliminary results.

Teeth extracted from 98 people aged 18-77 yr, living in the urban Haifa Bay area or in rural kibbutzim (communal farms) in northern and north-central Israel were analyzed with a graphite furnace atomic absorption spectrophotometer. There were no significant differences in lead levels in teeth for the same age ranges between urban and rural areas, despite differences in motorization rates. We assume that the daily mobility of the residents, the short distances between settlements, and the common origin of their food have a greater effect on the lead level in teeth than do differences in environmental lead in areas of low pollution. New immigrants from Ethiopia and people originating from India and Yemen have lower lead levels in teeth than long date immigrants, but due to different factors. On the other hand, immigrants from Argentina have higher lead levels in teeth in comparison with long date immigrants.

Adult↗

PubMedDate not supplied

Tumors of the major and minor salivary glands: review of 25 years of experience.

Reports from various countries, but never from Israel, have presented demographic data and the relative frequency of various salivary gland tumors. We reviewed 25 years of experience with-245 patients treated for salivary gland tumors, arising in the parotid [142 patients [pts], 57.9%], submandibular [34 pts, 13.9%], sublingual [2 pts, 0.8%] and minor salivary glands [67 pts, 27.3%]. Of these, 73.5% were classified as benign and 26.5% were classified as malignant. The tumors were analyzed according to sex and age of the pts, histopathological type and site. There was a female preponderance [1.16:1.0] for the benign tumors and a male preponderance [1.32:1.0] for the malignant tumors. The mean age for pts with malignant tumors was 12.6 years more than for pts with benign tumors [55.2 +/- 2.2 and 42.6 +/- 2.6 years, respectively]. The principal site for benign tumors was the parotid gland [67.8%], followed by the minor salivary glands [18.9%] and the submandibular gland [13.3%]. We did not observe any benign tumors in the sublingual glands. The principal site for malignant tumors was the minor salivary glands [50.8%], followed by the parotid gland [30.8%], the submandibular gland [15.4%] and the sublingual gland [3.0%]. We present the proportional distribution of both benign and malignant tumors; pleomorphic adenoma was the most common benign tumor of epithelial origin [76.1%] while the most commonly encountered malignant tumor was adenocarcinoma [including the acinic-cell and low-grade polymorphous subtypes] [27.7%]. The most striking result of this study is the demonstration of a recent increase in the incidence of salivary malignant tumors, possibly as a result of greater exposure to ultraviolet radiation. It is highly probable that the increase in malignant tumors will continue during the coming years in countries with intense solar radiation over long periods of time.

Adult↗