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Biomedical subjects

D Laufer

Publications and source records attributed to D Laufer.

At least 127 records · Page 7Linked to original sources
PubMed1986

[Tetralogy of Fallot: long-term evolution following corrective surgery].

To evaluate the immediate and long term results of complete correction of tetralogy of Fallot (TF), we have reviewed the records of 275 children operated on in Geneva between 1972 and end 1984. The average age at operation was 6 7/12 years (range 7 months to 16 years). Postoperative follow-up ranged from 1 year to 12 years (average 3 7/12 years). The survival rate, taking into account immediate postoperative mortality, was 90 +/- 2% after one year, 88 +/- 2% after 5 years and 88 +/- 2% after 11 years for the entire patient group. The total mortality of 9.8% has markedly decreased in recent years (14.5% before and 5.7% after 1978). Mortality is highest within the first 30 days after the operation (20 cases, 7.3%). Mortality was higher after previous palliative surgery (5/51) and for children who had to be reoperated for a residual lesion (4/23). Once the first postoperative year has passed, mortality is low: 2 deaths occurred between 1 and 2 years, and one between 2 and 5 years after the operation. Cardiac catheterization in 218 patients between 2 months and one year after surgery showed severe residual pulmonary stenosis in 4 children which made reoperation necessary; a second operation was needed for a large left-to-right shunt in 5 cases, and because of a ventricular septal defect with residual pulmonary stenosis in 6 others. Pulmonary insufficiency was noted in 106 cases (38.5%) but only 3 children showed right heart insufficiency. One child underwent pulmonary valve replacement by Björk-Shiley prosthesis. It can be concluded that a child with surgically treated TF has excellent long term survival, and that life threatening complications after the first postoperative year are rare.

Adolescent↗
PubMed1986

The salivary flow rate and composition of whole and parotid resting and stimulated saliva in young and old healthy subjects.

Resting and stimulated whole and parotid salivary composition and flow rate were examined in 63 healthy volunteers. No significant differences were found between the young and old in secretion rates and salivary concentrations of sodium, potassium, calcium, magnesium, and total protein. The activity of amylase in the resting and stimulated parotid saliva was significantly lower in the old.

Adult↗
PubMed1986

Chronic Q fever endocarditis with massive splenomegaly in childhood.

Two children with congenital heart disease developed persistent fever, anemia, and hepatosplenomegaly. Both were shown to have intracardiac vegetations and evidence of infection with Coxiella burnetti. Thus, the same clinical manifestations of Q fever may develop in both children and adults.

Adolescent↗
PubMed1986

Computer-aided diagnosis of odontogenic lesions.

4 cysts and 8 tumors of odontogenic origin have been described for the computer in terms of the prevalence of the associated clinical and radiological findings. Symptom prevalence as given in the literature and modified by our own experience was stated quantitatively as incidence ratios so that Bayes' formula could be used to calculate the probability of each disorder for each set of patient data. The model was applied to 48 cases whose lesions were identified by histopathology following surgery. In all cases, the actual lesion was listed in the computer-produced differential diagnosis, in 94% of the cases the lesion headed the list, and in 75% a probability of 0.85 or greater was achieved. The model can thus be applied to patients awaiting surgery to obtain a reliable differential diagnosis for guiding the medical staff in the proper management of the patient.

Adolescent↗
PubMed1985

Use of Hedstrom file for removal of fractured root tips.

The foregoing case report describes a procedure that can be used to remove newly fractured roots. It is recommended that a Hedstrom file be used in cases in which the roots are loosened before they are fractured and provided that proper visibility and sufficient space in the root canal in which to introduce the file exist. This method, used alone or in combination with closed or open procedures, can be helpful for removing roots that are close to the maxillary sinus or mandibular canal. In the aforementioned case, the Hedstrom file's being threaded into the root tip was a safeguard against pushing the root tips into the surrounding anatomic structures. A method of using a Hedstrom file has been described for the removal of newly fractured root tips. If conditions are adequate, this method is simple and effective.

Adolescent↗
PubMed1984

Cytogenetic study in a mentally retarded child with Bloom syndrome and acute lymphoblastic leukemia.

Bloom syndrome (BS) was diagnosed in a 7-year-old boy during hospitalization for acute lymphoblastic leukemia (ALL). The patient had most of the signs of BS along with some atypical manifestations: absence of telangiectases, obesity, and moderate mental retardation. Results of the cytogenetic studies were fully consistent with the diagnosis of BS: the occurrence of quadriradial figures and a very high incidence of sister-chromatid exchanges (SCE). This child's ALL was of non-B, non-T type with the presence, at the time of diagnosis, of a marrow clone including two markers. A Yq - chromosome was detected in about 10% of PHA-stimulated lymphocytes but neither in bone marrow cells nor in skin fibroblasts. This case is the fifth instance of ALL out of 104 registered cases of BS.

Bloom Syndrome↗
PubMed1984

Perturbation of cobalt 60 radiation doses by metal objects implanted during oral and maxillofacial surgery.

The influence on cobalt 60 dose distributions of typical metal parts used in oral and maxillofacial surgery was studied. Relative doses were determined by exposing x-ray films in a polystyrene phantom set-up containing samples of Vitallium, titanium, and stainless steel. Optical densities were converted to doses with the aid of sensitometric curves. The results show that for normal incidence there is a 25% to 40% increase in dose at the entrance side of the metal and a 20% to 25% decrease in dose at the exit side. The enhancement effect falls off rapidly and becomes negligible at about 1 mm from the interface. The reduction effect decreases more gradually and is still evident at distances of a few centimeters. These dose perturbations should be taken into account in the planning of radiation therapy for patients in whom metal objects have been implanted.

Absorptiometry, Photon↗
PubMed1981

Dental extractions during anticoagulant therapy.

1. 15 patients, whose therapy with the anticoagulant Coumarin was not discontinued, were observed for bleeding following dental extractions. 2. There was no significant bleeding in these patients as compared to 15 others whose Coumarin therapy was temporarily interrupted. 3. Patients with prosthetic heart valves should preferably be hospitalized for dental extractions. but Coumarin/anticoagulant therapy need not be discontinued. The procedures can safely be done within a therapeutic range of 20-30% P.T.

Adult↗
PubMed1979

Treatment of oral hemangiomas with local sclerosing agents.

Twenty-four cases of hemangiomas of various sizes in the oral cavity and lips were treated with local injections of a sclerosing agent (3% Sotradecol - sodium tetradecyl sulfate). No side effects were noticed and the lesions disappeared without scarring. The article discusses the practical aspects of this therapy.

Adolescent↗
PubMed1978

Sialochemistry of patients with rheumatoid arthritis. Electrolytes, protein, and salivary IgA.

Sialochemistry was undertaken to detect subclinical involvement of salivary glands in patients with rheumatoid arthritis (RA). The concentrations of salivary sodium and IgA were significantly elevated in 24 percent of the RA patients. Eighty per cent of the patients with elevated sodium and IgA concentrations had keratoconjunctivitis sicca as well. No correlation between serum and salivary IgA levels was found. The results indicate that salivary sodium and IgA levels can be used for detection of subclinical salivary gland involvement and for follow-up of RA patients.

Adolescent↗