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Biomedical subjects

D Latal

Publications and source records attributed to D Latal.

33 records · Page 2Linked to original sources

[Accuracy of computed tomography in urological tumour diagnosis (author's transl)].

The value of CT in comparison with other partly invasive diagnostic measures was assessed in 127 urological patients with the diagnosis "expansive process of the kidney" or "tumour" (bladder, prostate and testicles). The significance, the margin of error and correspondence with surgical and medical findings are described. Computed tomography represents a valuable supplement to tumour diagnosis in urology. It is accurate, offers basic information for radiation planning and polychemotherapy, is useful in control check-ups of patients with tumours of the kidney or testicles and should be employed in spite of the relatively high expense if a tumour is suspected.

Diagnosis, Differential

[Clinical and diagnostic value of computed tomography in retroperitoneal space-occupying extrarenal and extrapancreatic lesions (author's transl)].

In order to determine the diagnostic accuracy and clinical value of CT in the detection of retroperitoneal tumours and tumour-like conditions an evaluation was conducted of 397 CT examinations in 287 patients. Staging, monitoring of therapy and detection of relapse of the disease are the main indications for CT examination. CT should be used in the first place in the course of diagnostic staging procedures of patients with malignant tumours and tumour recurrence. This is justified by an overall diagnostic accuracy of 90% and the ability of CT to show up the exact localization and extent of tumours and the different patterns of lymph node involvement.

Adolescent

Nutritional risk factors in urinary stone disease.

The relationships between eating and drinking habits, and serum as well as 24-hour urinary concentrations of calcium, inorganic phosphate uric acid and urinary pH were studied in 379 patient in whom stones form. The 24-hour urinary calcium excretion was found to be increased in patients who preferably eat animal proteins and farinaceous foods (p less than 0.1). Regarding drinking habits, urinary calcium and inorganic phosphate excretion was found to increase significantly as a function of alcohol ingestion (p less than 0.01 and p less than 0.001, respectively). Similarly, an increased alcohol intake was found to be associated with higher serum uric acid concentrations (p less than 0.01). A significant increase in urinary pH was confined to patients preferably eating vegetables (p less than 0.005). The results of our study suggest alcohol consumption to be a potentiating factor for the risk of stone formation.

Adolescent

[Computerised tomography as a means to classify bladder tumours according to stages (author's transl)].

On the basis of examinations carried out in 27 patients (26 histologically verified carcinomas of the bladder), it is shown that computerised tomography considerably improved the preoperative classification, into stages, of the bladder tumours coming up for surgery. Endovesical growth cannot be differentiated with certainty. Perivesical expansion of tumours and the identification of lymphatic node metastasis can be covered significantly better by computerised tomography than by other methods.

Aged

[Arterial embolic occlusion in tumours of kidney and bladder (author's transl)].

Arterial embolic occlusion is a comparatively new therapeutic method in urology. This procedure is performed now before operation of tumours of the kidney and as a palliative measure in the treatment of renal and bladder cancer. The procedure and mode of administration of the different materials for occlusion are described. The difficulties arising during embolic occlusion and the subjective response of the patient to this treatment are discussed. Furthermore, the advantages and disadvantages of this method and, in particular, undesirable side effects are pointed out.

Arteries

[Lymphangiography--a guide in tumor nephrectomy?].

The anatomy of renal lymphatic vessels is described. Marked discrepancy in the results of lymphangiography carried out in 47 patients with kidney tumor and the histological examination of the lymphatic tissue removed by lymphadenectomy is discussed. However, there is a conclusive evidence of the prognostic value of lymphangiography concerning the postoperative survival of patients with kidney tumors. Due to misinterpretations of lymphangiography, the variability of the lymphatic outflow of the kidney as well as the predominant hematogenic spread of metastases of kidney tumors, lymphangiography does not appear to be a valuable diagnostic approach in renal carcinoma.

Humans

[The role of urinary excretion of magnesium in patients with urolithiasis with special respect to recurrence rate of stone formation (author's transl)].

154 patients with urolithiasis and 24 normal controls were investigated for serum levels and urinary excretion of magnesium. No significant difference in urinary magnesium excretion could be found neither between stone forming patients and normal controls nor between patients with different types of stones. There was also no difference in serum concentrations of magnesium. A disturbance in excretion of magnesium in urine could not be related to increased recurrence rate of stone formation. According to these findings it is doubtful whether a disturbance in urinary excretion of magnesium plays an important role in stone formation. Therefore the determination of magnesium excretion can be neglected in the course of routine investigation of patients with urinary calculi.

Adult

[Clinical aspects of cystinuria and its treatment by thiola (author's transl)].

Cystinuria is an inherited disorder of amino acid transport affecting the epithelial cells of the renal tubules and the gastro-intestinal tract. Treatment consists of the prophylaxis of recurrent urolithiasis, which is the clinical manifestation of the disease. Long-term treatment with alpha-mercapto-propionyl-glycine (MPG; Thiola) promises to be successful. 3 cytinuric patients with recurrent urolithiasis underwent treatment over a period of 6 months. Therapy was controlled by regular follow-up investigations of the urinary excretion and serum levels of cystine and di-basic amino acids. The results did not indicate any permanent decrease in cystine excretion. No recurrence of renal calculi was observed. The possibility is discussed of a direkt mechanism of action of the drug on the metabolism of the involved amino acids.

Amino Acids